Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow VWF rightarrow Polyclonal VWF  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • DNA Lambda C1857 S7 Vector
 • Mineralocorticoid receptor (NR3C2) Recombinant Protein
 • AMACR Peptide
 • UDP glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1... ELISA Kit
 • ACTH (POMC) Antibody
 • TCF4 Antibody
 • 1,2-dihydroxy-3-keto-5-meth ylthiopentene dioxygenase (adi1) Recombinant Protein
 • Glycerol-3-Phosphate Dehydrogenase 2, Mitochondrial (GPD2) ELISA Kit
 • Mucin-5AC (MUC5AC) ELISA Kit
 • Arginase II (Arg2) ELISA Kit
 • dickkopf homolog 3 (Xenopus laevis) (DKK3) ELISA Kit
 • Fatty acid-binding protein (FABP3) Antibody
 • tyrosine hydroxylase (TH) ELISA Kit
 • HLA Class 1 Antigen B35,B57,B75,B77(X-Reactive) Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-VWF antibody :: Goat anti-Human VWF / Von Willebrand Factor Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS242367
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

VWF / Von Willebrand Factor, Polyclonal Antibody

 Also Known As   

Goat Polyclonal (IgG) to Human VWF / Von Willebrand Factor

 Product Synonym Names    Anti-VWF / Von Willebrand Factor Antibody IHC-plus; VWF; Coagulation factor VIII VWF; F8VWF; VWD; Von Willebrand factor; Human VWF; Von Willebrand Factor
 Product Gene Name   

anti-VWF antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    gene 613554
 3D Structure    ModBase 3D Structure for P04275
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Goat
 Species Reactivity    Human
Section Bar
 Specificity    Recognizes human vWF.
 Purity/Purification    Caprylic acid and ammonium sulfate precipitations, followed by Protein G affinity chromatography
 Form/Format    10 mM HEPES, 0.15 M sodium chloride, pH 7.4, 50% glycerol.
 Concentration    1 mg/ml (lot specific)
Section Bar
 Target Species    Human
 Immunogen Description    Human von Willebrand Factor (vWF) purified from plasma.
 Immunogen Type    Purified protein
 Immunogen    VWF / Von Willebrand Factor antibody was raised against human von Willebrand Factor (vWF) purified from plasma.
Section Bar
 Preparation and Storage    Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
 Other Notes    Small volumes of anti-VWF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-VWF antibody

   Von Willebrand Factor (VWF) functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand's disease.
 Applications Tested/Suitable for anti-VWF antibody   

Immunohistochemistry (IHC - Paraffin), ELISA (EIA), Immunoelectrophoresis

 Application Notes for anti-VWF antibody    ELISA, IE, IHC-P (5 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
Section Bar
 Immunohistochemistry (IHC) of anti-VWF antibody    Anti-VWF antibody IHC of human brain, cortex, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-VWF antibody Immunohistochemistry (IHC) (IHC) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for VWF. It may not necessarily be applicable to this product.
 NCBI GI #    89191868
 NCBI GeneID    7450
 NCBI Accession #    NP_000543.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000552.3 [Other Products]
Section Bar
 UniProt Primary Accession #    P04275 [Other Products]
 UniProt Secondary Accession #    Q8TCE8; Q99806 [Other Products]
 UniProt Related Accession #    P04275 [Other Products]
 Molecular Weight    38,745 Da
Table BarTOPTable Bar
 NCBI Official Full Name    von Willebrand factor preproprotein
 NCBI Official Synonym Full Names    von Willebrand factor
 NCBI Official Symbol    VWF [Similar Products]
 NCBI Official Synonym Symbols   
VWD; F8VWF
[Similar Products]
 NCBI Protein Information    von Willebrand factor; coagulation factor VIII VWF
 UniProt Protein Name    von Willebrand factor
 UniProt Synonym Protein Names   
von Willebrand antigen II
 Protein Family    von Willebrand factor
 UniProt Gene Name    VWF [Similar Products]
 UniProt Synonym Gene Names    F8VWF; vWF [Similar Products]
 UniProt Entry Name    VWF_HUMAN
Section Bar
 NCBI Summary for VWF    The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand's disease. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for VWF    VWF: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. Defects in VWF are the cause of von Willebrand disease type 1 (VWD1). A common hemorrhagic disorder due to defects in von Willebrand factor protein and resulting in impaired platelet aggregation. Von Willebrand disease type 1 is characterized by partial quantitative deficiency of circulating von Willebrand factor, that is otherwise structurally and functionally normal. Clinical manifestations are mucocutaneous bleeding, such as epistaxis and menorrhagia, and prolonged bleeding after surgery or trauma. Defects in VWF are the cause of von Willebrand disease type 2 (VWD2). A hemorrhagic disorder due to defects in von Willebrand factor protein and resulting in impaired platelet aggregation. Von Willebrand disease type 2 is characterized by qualitative deficiency and functional anomalies of von Willebrand factor. It is divided in different subtypes including 2A, 2B, 2M and 2N (Normandy variant). The mutant VWF protein in types 2A, 2B and 2M are defective in their platelet- dependent function, whereas the mutant protein in type 2N is defective in its ability to bind factor VIII. Clinical manifestations are mucocutaneous bleeding, such as epistaxis and menorrhagia, and prolonged bleeding after surgery or trauma. Defects in VWF are the cause of von Willebrand disease type 3 (VWD3). A severe hemorrhagic disorder due to a total or near total absence of von Willebrand factor in the plasma and cellular compartments, also leading to a profound deficiency of plasmatic factor VIII. Bleeding usually starts in infancy and can include epistaxis, recurrent mucocutaneous bleeding, excessive bleeding after minor trauma, and hemarthroses.

Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Extracellular matrix; Secreted; Cell adhesion

Chromosomal Location of Human Ortholog: 12p13.3

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; endoplasmic reticulum; extracellular region; external side of plasma membrane

Molecular Function: integrin binding; collagen binding; identical protein binding; protein binding; protein homodimerization activity; protease binding; chaperone binding; immunoglobulin binding; protein N-terminus binding; glycoprotein binding

Biological Process: platelet activation; extracellular matrix organization and biogenesis; platelet degranulation; hemostasis; response to wounding; blood coagulation; cell adhesion; liver development; blood coagulation, intrinsic pathway; protein homooligomerization; cell-substrate adhesion; placenta development

Disease: Von Willebrand Disease, Type 3; Von Willebrand Disease, Type 1; Von Willebrand Disease, Type 2
Table BarTOPTable Bar
 Research Articles on VWF    1. A high von Willebrand factor level reflects endothelial damage or dysfunction, which is a mechanism known to be involved in vascular lesions, and may promote the development of hypertensive retinopathy.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-VWF antibodyPathways associated with anti-VWF antibody
 Reference Product  PubMed Publications
 ADAMTS13 antibody  >617 publications with VWF and ADAMTS13
 VEGFA antibody  >46 publications with VWF and VEGFA
 GP1BA antibody  >18 publications with VWF and GP1BA
 ITGA2B antibody  >7 publications with VWF and ITGA2B
 GATA2 antibody  >1 publications with VWF and GATA2
 Products by Pathway  Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
Diseases associated with anti-VWF antibodyOrgans/Tissues associated with anti-VWF antibody
 Disease Name  Pubmed Publications
 Vascular Diseases Antibodies  >1990 publications with VWF and Vascular Diseases
 Cardiovascular Diseases Antibodies  >1973 publications with VWF and Cardiovascular Diseases
 Thrombosis Antibodies  >1415 publications with VWF and Thrombosis
 Heart Diseases Antibodies  >617 publications with VWF and Heart Diseases
 Inflammation Antibodies  >599 publications with VWF and Inflammation
 Atherosclerosis Antibodies  >368 publications with VWF and Atherosclerosis
 Kidney Diseases Antibodies  >317 publications with VWF and Kidney Diseases
 Hypertension Antibodies  >293 publications with VWF and Hypertension
 Disease Models, Animal Antibodies  >276 publications with VWF and Disease Models, Animal
 Necrosis Antibodies  >257 publications with VWF and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5853 publications with VWF and Blood
 Vascular Antibodies  >2956 publications with VWF and Vascular
 Heart Antibodies  >647 publications with VWF and Heart
 Muscle Antibodies  >357 publications with VWF and Muscle
 Bone Antibodies  >327 publications with VWF and Bone
 Kidney Antibodies  >302 publications with VWF and Kidney
 Liver Antibodies  >274 publications with VWF and Liver
 Brain Antibodies  >262 publications with VWF and Brain
 Umbilical Cord Antibodies  >252 publications with VWF and Umbilical Cord
 Skin Antibodies  >239 publications with VWF and Skin
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions