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anti-sanA antibody :: Rabbit Vancomycin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS623181 anti-sanA antibody
Unit / Price
0.1 mL  /  $320 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Vancomycin (sanA), Polyclonal Antibody

★Popular Item★
 Also Known As   

Vancomycin

 Product Synonym Names    Anti -Vancomycin
 Product Gene Name   

anti-sanA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    NC_000913.2 (2230900..2231619)
 3D Structure    ModBase 3D Structure for P0AFY2
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
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 Specificity    Recognizes Vancomycin: 100%.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography
 Form/Format    Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
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 Immunogen    Vancomycin conjugated to KLH
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-sanA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-sanA antibody

   Vancomycin is an aminoglycoside antibiotic, used in the treatment of infections caused by Gram-positive bacteria. vancomycin is not active against Gram-negative bacteria (except some non-gonococcal species of Neisseria). The main target of this antibiotic is the D-alanyl-D-alanine terminal dipeptide of peptidoglycan precursors, used by bacteria for constructing their cell walls. This prevents the reaction used to link peptidoglycan precursors together from taking place. Vancomycin binds with the substrate, not the enzyme, in contrast to the way penicillin inhibits peptidoglycan synthesis.

The large hydrophilic molecule is able to form hydrogen bond interactions with the terminal D-alanyl-D-alanine moieties of the NAM/NAG-peptides. Under normal circumstances, this is a five-point interaction. This binding of vancomycin to the D-Ala-D-Ala prevents cell wall synthesis in two ways. It prevents the synthesis of the long polymers of N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) that form the backbone strands of the bacterial cell wall, and it prevents the backbone polymers that do manage to form from cross-linking with each other.
 Product Categories/Family for anti-sanA antibody    Antibodies; Abs to Drugs
 Applications Tested/Suitable for anti-sanA antibody   

ELISA (EL/EIA)

 Application Notes for anti-sanA antibody    Suitable for use in Indirect ELISA.
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NCBI/Uniprot data below describe general gene information for sanA. It may not necessarily be applicable to this product.
 NCBI GI #    16130082
 NCBI GeneID    949003
 NCBI Accession #    NP_416649.1 [Other Products]
 NCBI GenBank Nucleotide #    NC_000913.2 [Other Products]
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 UniProt Primary Accession #    P0AFY2 [Other Products]
 UniProt Secondary Accession #    P33017; P76438; Q2MAT5 [Other Products]
 Molecular Weight    27,287 Da [Similar Products]
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 NCBI Official Full Name    vancomycin high temperature exclusion protein; mutants have a defective envelope more permeable to vancomycin at 42 degrees
 NCBI Official Symbol    sanA [Similar Products]
 NCBI Official Synonym Symbols   
ECK2137; JW2132; sfiX; yeiF
[Similar Products]
 NCBI Protein Information    vancomycin high temperature exclusion protein; mutants have a defective envelope more permeable to vancomycin at 42 degrees
 UniProt Protein Name    Protein SanA
 Protein Family    Vancomycin B-type resistance protein
 UniProt Gene Name    sanA [Similar Products]
 UniProt Synonym Gene Names    yeiF [Similar Products]
 UniProt Entry Name    SANA_ECOLI
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 NCBI Summary for sanA    ydcF and ycbC (COG1434) and sanA and yjgQ (COG2949) are four members of the DUF218 superfamily (PF02698). [More information is available at EcoGene: EG12025]. sanA encodes an inner membrane protein which is likely to be involved in cell envelope barrier functions. [More information is available at EcoCyc: EG12025].
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 UniProt Comments for sanA    Function: Participates in the barrier function of the cell envelope.

Subcellular location: Cell inner membrane; Single-pass membrane protein.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-sanA antibody
 Reference Product  PubMed Publications
 cdd antibody  >1 publications with sanA and cdd
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