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anti-VNN1 antibody :: Rabbit anti-Human Vanin 1 (VNN1) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2004746 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.02 mg  /  $130 +1 FREE 8GB USB
0.05 mg  /  $175 +1 FREE 8GB USB
0.1 mg  /  $225 +1 FREE 8GB USB
0.2 mg  /  $340 +1 FREE 8GB USB
1 mg  /  $800 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Vanin 1 (VNN1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to Vanin 1 (VNN1)

 Product Gene Name   

anti-VNN1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG SEF-VE GRYYLQICTL LKCKTTNLNT CGDSAETAST RFEMFSLSGT FGTQYVFPEV LLSENQLAPG EFQVSTDGRL FSLKPTSGPV LTVTLFGRLY EKDWASNASS GLTAQAR
 OMIM    AJ132099 mRNA
 3D Structure    ModBase 3D Structure for O95497
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody is a rabbit polyclonal antibody raised against VNN1. It has been selected for its ability to recognize VNN1 in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
 Concentration    200ug/ml (lot specific)
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 Immunogen    Recombinant VNN1 (Val389~Arg497) expressed in E.coli.
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2066997
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-VNN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-VNN1 antibody    Knock-Out Validation Antibody
 Applications Tested/Suitable for anti-VNN1 antibody   

Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)

 Application Notes for anti-VNN1 antibody    Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
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 Western Blot (WB) Knockout Verification of anti-VNN1 antibody    Knockout Verification: Lane 1: Wild-type BXPC-3 cell lysate
Lane 2: VNN1 knockout BXPC-3 cell lysate
Predicted MW: 57kDa ;Observed MW: 57kDa;Primary Ab: 3ug/ml Rabbit Anti-Human VNN1 Antibody;Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody;
anti-VNN1 antibody Western Blot (WB) Knockout Verification (WB) image
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 Western Blot (WB) of anti-VNN1 antibody    Western Blot; Sample: Recombinant VNN1, Human.
anti-VNN1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-VNN1 antibody    DAB staining on IHC-P; Samples: Human Liver Tissue.
anti-VNN1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-VNN1 antibody    DAB staining on IHC-P; Samples: Human Stomach Tissue
anti-VNN1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-VNN1 antibody    DAB staining on IHC-P; Samples: Human Kidney Tissue.
anti-VNN1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for VNN1. It may not necessarily be applicable to this product.
 NCBI GI #    223633991
 NCBI GeneID    8876
 NCBI Accession #    NP_004657.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004666.2 [Other Products]
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 UniProt Primary Accession #    O95497 [Other Products]
 UniProt Secondary Accession #    Q4JFW6; Q4VAS7; Q4VAS8; Q4VAS9; Q9UF16; Q9UJF4; A8K310 [Other Products]
 UniProt Related Accession #    O95497 [Other Products]
 Molecular Weight    57,012 Da
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 NCBI Official Full Name    pantetheinase
 NCBI Official Synonym Full Names    vanin 1
 NCBI Official Symbol    VNN1 [Similar Products]
 NCBI Official Synonym Symbols   
HDLCQ8; Tiff66
[Similar Products]
 NCBI Protein Information    pantetheinase
 UniProt Protein Name    Pantetheinase
 UniProt Synonym Protein Names   
Pantetheine hydrolase; Tiff66; Vascular non-inflammatory molecule 1; Vanin-1
 Protein Family    Pantetheinase
 UniProt Gene Name    VNN1 [Similar Products]
 UniProt Synonym Gene Names    Vanin-1 [Similar Products]
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 NCBI Summary for VNN1    This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24. [provided by RefSeq, Feb 2009]
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 UniProt Comments for VNN1    VNN1: Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Belongs to the CN hydrolase family. BTD/VNN subfamily.

Protein type: Cell adhesion; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; EC 3.5.1.92; Hydrolase; Membrane protein, GPI anchor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 6q23.2

Cellular Component: extracellular region; integral component of membrane; plasma membrane

Molecular Function: pantetheine hydrolase activity

Biological Process: acute inflammatory response; C-terminal protein lipidation; cell motility; chronic inflammatory response; inflammatory response; innate immune response; neutrophil degranulation; pantothenate metabolic process; positive regulation of T cell differentiation in thymus; response to oxidative stress
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 Research Articles on VNN1    1. findings suggest that the metabolic pathway catalyzed by VNN1 pantetheinase plays a suppressive role in IAV infection in the respiratory tract, especially in severe conditions under hypercytokinemia
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-VNN1 antibodyDiseases associated with anti-VNN1 antibody
 Products by Pathway  Pathway Diagram
 Pantothenate And CoA Biosynthesis Pathway antibodies  Pantothenate And CoA Biosynthesis Pathway Diagram
 Pantothenate And CoA Biosynthesis Pathway antibodies  Pantothenate And CoA Biosynthesis Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >8 publications with VNN1 and Inflammation
 Liver Diseases Antibodies  >5 publications with VNN1 and Liver Diseases
 Cardiovascular Diseases Antibodies  >5 publications with VNN1 and Cardiovascular Diseases
 Fatty Liver Antibodies  >4 publications with VNN1 and Fatty Liver
 Hypertension Antibodies  >3 publications with VNN1 and Hypertension
 Blood Coagulation Disorders Antibodies  >2 publications with VNN1 and Blood Coagulation Disorders
 Poisoning Antibodies  >2 publications with VNN1 and Poisoning
 Hyperplasia Antibodies  >2 publications with VNN1 and Hyperplasia
 Hemorrhage Antibodies  >2 publications with VNN1 and Hemorrhage
 Fibrosis Antibodies  >1 publications with VNN1 and Fibrosis
Organs/Tissues associated with anti-VNN1 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >20 publications with VNN1 and Blood
 Liver Antibodies  >12 publications with VNN1 and Liver
 Ovary Antibodies  >5 publications with VNN1 and Ovary
 Bone Antibodies  >4 publications with VNN1 and Bone
 Bone Marrow Antibodies  >4 publications with VNN1 and Bone Marrow
 Muscle Antibodies  >2 publications with VNN1 and Muscle
 Intestine Antibodies  >1 publications with VNN1 and Intestine
 Kidney Antibodies  >1 publications with VNN1 and Kidney
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