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anti-VNN1 antibody :: Rabbit anti-Human Vanin 1 (VNN1) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2005256 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Western Blot
Unit / Price
0.01 mg  /  $115 +1 FREE 8GB USB
0.02 mg  /  $135 +1 FREE 8GB USB
0.05 mg  /  $190 +1 FREE 8GB USB
0.1 mg  /  $245 +1 FREE 8GB USB
0.2 mg  /  $370 +1 FREE 8GB USB
1 mg  /  $880 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Vanin 1 (VNN1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Biotin-Linked Antibody to Vanin 1 (VNN1)

 Product Gene Name   

anti-VNN1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 6; NC_000006.11 (133001997..133035194, complement). Location: 6q23-q24
 OMIM    603570
 3D Structure    ModBase 3D Structure for O95497
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody is a rabbit polyclonal antibody raised against VNN1. It has been selected for its ability to recognize VNN1 in immunohistochemical staining and western blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
 Concentration    200ug/ml (lot specific)
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 Immunogen    Recombinant VNN1 (Leu36~Leu223) with N-terminal His-Tag expressed in E.coli.
 Accession No.    RPC598Hu01
 Unconjugated Antibody    The unconjugated antibody version of this item is also available as catalog #MBS2001452
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-VNN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-VNN1 antibody    Biotin Antibody
 Applications Tested/Suitable for anti-VNN1 antibody   

WB, ICC, IHC-P, IHC-F, ELISA

 Application Notes for anti-VNN1 antibody    Western blotting: 1:50-400
Immunocytochemistry in formalin fixed cells: 1:50-500
Immunohistochemistry in formalin fixed frozen section: 1:50-500
Immunohistochemistry in paraffin section: 1:10-100
Enzyme-linked Immunosorbent Assay: 1:100-200
Optimal working dilutions must be determined by end user.
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 Western Blot of anti-VNN1 antibody    anti-VNN1 antibody Western Blot (WB) image
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NCBI/Uniprot data below describe general gene information for VNN1. It may not necessarily be applicable to this product.
 NCBI GI #    119568405
 NCBI GeneID    8876
 NCBI Accession #    EAW48020.1 [Other Products]
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 UniProt Primary Accession #    O95497 [Other Products]
 UniProt Secondary Accession #    Q4JFW6; Q4VAS7; Q4VAS8; Q4VAS9; Q9UF16; Q9UJF4; A8K310 [Other Products]
 UniProt Related Accession #    O95497 [Other Products]
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 NCBI Official Full Name    vanin 1
 NCBI Official Synonym Full Names    vanin 1
 NCBI Official Symbol    VNN1 [Similar Products]
 NCBI Official Synonym Symbols   
HDLCQ8; Tiff66
[Similar Products]
 NCBI Protein Information    pantetheinase; vanin-1; vannin 1; pantetheine hydrolase; vascular non-inflammatory molecule 1
 UniProt Protein Name    Pantetheinase
 UniProt Synonym Protein Names   
Pantetheine hydrolase; Tiff66; Vascular non-inflammatory molecule 1
 Protein Family    Pantetheinase
 UniProt Gene Name    VNN1 [Similar Products]
 UniProt Synonym Gene Names    Vanin-1 [Similar Products]
 UniProt Entry Name    VNN1_HUMAN
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 NCBI Summary for VNN1    This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24. [provided by RefSeq, Feb 2009]
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 UniProt Comments for VNN1    VNN1: Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Belongs to the CN hydrolase family. BTD/VNN subfamily.

Protein type: Cell adhesion; Motility/polarity/chemotaxis; Hydrolase; Membrane protein, GPI anchor; EC 3.5.1.92; Membrane protein, integral; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis

Chromosomal Location of Human Ortholog: 6q23-q24

Cellular Component: integral to membrane; plasma membrane

Molecular Function: pantetheine hydrolase activity

Biological Process: positive regulation of T cell differentiation in the thymus; cell-cell adhesion; chronic inflammatory response; pantothenate metabolic process; innate immune response; response to oxidative stress; inflammatory response; cell motility; acute inflammatory response
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 Research Articles on VNN1    1. Liver contributes to Vanin-1 secretion in serum and PPARalpha is a limiting factor in serum Vnn1 production.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-VNN1 antibodyPathways associated with anti-VNN1 antibody
 Reference Product  PubMed Publications
 SRY antibody  >1 publications with VNN1 and SRY
 Products by Pathway  Pathway Diagram
 Pantothenate And CoA Biosynthesis Pathway antibodies  Pantothenate And CoA Biosynthesis Pathway Diagram
 Pantothenate And CoA Biosynthesis Pathway antibodies  Pantothenate And CoA Biosynthesis Pathway Diagram
Diseases associated with anti-VNN1 antibodyOrgans/Tissues associated with anti-VNN1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >5 publications with VNN1 and Inflammation
 Cardiovascular Diseases Antibodies  >4 publications with VNN1 and Cardiovascular Diseases
 Hypertension Antibodies  >3 publications with VNN1 and Hypertension
 Nervous System Diseases Antibodies  >1 publications with VNN1 and Nervous System Diseases
 Hemorrhage Antibodies  >1 publications with VNN1 and Hemorrhage
 Fibrosis Antibodies  >1 publications with VNN1 and Fibrosis
 Blood Coagulation Disorders Antibodies  >1 publications with VNN1 and Blood Coagulation Disorders
 Hyperplasia Antibodies  >1 publications with VNN1 and Hyperplasia
 Atherosclerosis Antibodies  >1 publications with VNN1 and Atherosclerosis
 Fatty Liver Antibodies  >1 publications with VNN1 and Fatty Liver
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >16 publications with VNN1 and Blood
 Liver Antibodies  >4 publications with VNN1 and Liver
 Ovary Antibodies  >2 publications with VNN1 and Ovary
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