AAA51917.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
81,276 Da
NCBI Official Full Name
vascular cell adhesion molecule 1
NCBI Official Synonym Full Names
vascular cell adhesion molecule 1
NCBI Protein Information
vascular cell adhesion protein 1; CD106 antigen
UniProt Protein Name
Vascular cell adhesion protein 1
UniProt Synonym Protein Names
INCAM-100
UniProt Synonym Gene Names
UniProt Entry Name
VCAM1_HUMAN
NCBI Summary for VCAM1
This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]
UniProt Comments for VCAM1
VCAM1: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p32-p31
Cellular Component: Golgi apparatus; extracellular space; microvillus; cell surface; endoplasmic reticulum; early endosome; integral to membrane; apical part of cell; plasma membrane; podosome; sarcolemma; external side of plasma membrane; filopodium
Molecular Function: integrin binding; amine oxidase activity; cell adhesion molecule binding
Biological Process: response to nicotine; extracellular matrix organization and biogenesis; regulation of immune response; chronic inflammatory response; viral reproduction; cytokine and chemokine mediated signaling pathway; cell-matrix adhesion; heart development; response to lipopolysaccharide; heterophilic cell adhesion; leukocyte adhesion; response to ethanol; response to zinc ion; B cell differentiation; membrane to membrane docking; response to hypoxia; positive regulation of T cell proliferation; response to ionizing radiation; amine metabolic process; leukocyte tethering or rolling; cell adhesion; acute inflammatory response; response to nutrient; aging
Research Articles on VCAM1
Precautions
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Products associated with anti-VCAM1 antibody
Pathways associated with anti-VCAM1 antibody
Diseases associated with anti-VCAM1 antibody
Organs/Tissues associated with anti-VCAM1 antibody
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