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anti-AVPR2 antibody :: Rabbit anti-Rat Vasopressin Receptor V2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS617332 anti-AVPR2 antibody
Unit / Price
0.1 mg  /  $745 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Vasopressin Receptor V2 (AVPR2), Polyclonal Antibody

 Also Known As   

Vasopressin Receptor V2 (AVR-V2)

 Product Synonym Names    Anti -Vasopressin Receptor V2 (AVR-V2)
 Product Gene Name   

anti-AVPR2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: X; NC_000023.10 (153167985..153172620). Location: Xq28
 OMIM    300538
 3D Structure    ModBase 3D Structure for P30518
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Rat
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 Specificity    Recognizes rat Arginine Vasopressin Receptor V2 (AVR-V2). The immunogen shows no significant sequence homology with AVR-V1a or AVR-V1b. Species sequence homology: 95% mouse, 90% human and 80% porcine.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.5, 0.1% BSA, 40% glycerol.
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 Immunogen    A 21 amino acid peptide sequence from the 3rd cytoplasmic domain of rat AVR-V2.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-AVPR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-AVPR2 antibody

   Vasopressin (AVP, Arginine-8-Vasopressin), the antidiuretic hormone is cyclic nonapeptide invovled in the homeostasis of body fluid osmolality, blood volume, vascular tone, and blood pressure. Specific actions of AVP include inhibition of diuresis, contraction of smooth muscle, stimulation of liver glycogenesis, and modulation of ACTH release from pituitary. AVP belongs to the family of vasocative and mitogenic peptide invovled in normal and pathological cell growth and differentiation.
 Product Categories/Family for anti-AVPR2 antibody    Antibodies; Abs to Receptors
 Applications Tested/Suitable for anti-AVPR2 antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-AVPR2 antibody    Suitable for use in Western Blot and ELISA.
Dilution: Western Blot: 1-10ug/ml using ECL. An antibody made to the AVP-V2 peptide has detected a glycosylated band at ~62kD in membranes from rat inner medulla (2). N-glycanase treatment reduced the AVP-V2 size to about 36kD (deglycosylated form).
ELISA: 0.5-1ug/ml using 1ug/ml control peptide per well
Optimal dilution determined by the researcher.
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NCBI/Uniprot data below describe general gene information for AVPR2. It may not necessarily be applicable to this product.
 NCBI GI #    4557345
 NCBI GeneID    554
 NCBI Accession #    NP_000045.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000054.4 [Other Products]
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 UniProt Primary Accession #    P30518 [Other Products]
 UniProt Secondary Accession #    O43192; Q3MJD3; Q9UCV9 [Other Products]
 UniProt Related Accession #    P30518 [Other Products]
 Molecular Weight    40,279 Da [Similar Products]
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 NCBI Official Full Name    vasopressin V2 receptor isoform 1
 NCBI Official Synonym Full Names    arginine vasopressin receptor 2
 NCBI Official Symbol    AVPR2 [Similar Products]
 NCBI Official Synonym Symbols   
DI1; DIR; NDI; V2R; ADHR; DIR3; MGC126533; MGC138386
[Similar Products]
 NCBI Protein Information    vasopressin V2 receptor; AVPR V2; OTTHUMP00000026011; OTTHUMP00000026013; OTTHUMP00000198719; antidiuretic hormone receptor; renal-type arginine vasopressin receptor
 UniProt Protein Name    Vasopressin V2 receptor
 UniProt Synonym Protein Names   
AVPR V2; Antidiuretic hormone receptor; Renal-type arginine vasopressin receptor
 Protein Family    Vasopressin V2 receptor
 UniProt Gene Name    AVPR2 [Similar Products]
 UniProt Synonym Gene Names    ADHR; DIR; DIR3; V2R [Similar Products]
 UniProt Entry Name    V2R_HUMAN
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 NCBI Summary for AVPR2    This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing. [provided by RefSeq]
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 UniProt Comments for AVPR2    AVPR2: Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption. Defects in AVPR2 are the cause of nephrogenic syndrome of inappropriate antidiuresis (NSIAD). This disorder is characterized by an inability to excrete a free water load, with inappropriately concentrated urine and resultant hyponatremia, hypoosmolarity, and natriuresis. Defects in AVPR2 are the cause of diabetes insipidus nephrogenic X-linked (XNDI); also known as diabetes insipidus nephrogenic type 1. XNDI is caused by the inability of the renal collecting ducts to absorb water in response to arginine vasopressin. It is characterized by excessive water drinking (polydypsia), excessive urine excretion (polyuria), persistent hypotonic urine, and hypokalemia. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter; Receptor, GPCR; Membrane protein, integral; Transporter, aquaporin family; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: Golgi apparatus; integral to plasma membrane; endoplasmic reticulum; integral to membrane; plasma membrane; endosome

Molecular Function: protein binding; peptide binding; vasopressin receptor activity

Biological Process: I-kappaB kinase/NF-kappaB cascade; water transport; adenylate cyclase activation; positive regulation of systemic arterial blood pressure; excretion; cellular response to hormone stimulus; G-protein signaling, coupled to cAMP nucleotide second messenger; telencephalon development; regulation of systemic arterial blood pressure by vasopressin; positive regulation of protein ubiquitination; hemostasis; response to cytokine stimulus; positive regulation of cell proliferation; positive regulation of vasoconstriction; interferon-gamma production; renal water homeostasis; transmembrane transport

Disease: Nephrogenic Syndrome Of Inappropriate Antidiuresis; Diabetes Insipidus, Nephrogenic, X-linked
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 Research Articles on AVPR2    1. no asp-lys-ile and asp-arg-tyr mutations significantly altered cAMP production and cell surface expression of V2R in these cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-AVPR2 antibodyPathways associated with anti-AVPR2 antibody
 Reference Product  PubMed Publications
 AVP antibody  >33 publications with AVPR2 and AVP
 Products by Pathway  Pathway Diagram
 Aquaporin-mediated Transport Pathway antibodies  Aquaporin-mediated Transport Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Peptide GPCRs Pathway antibodies  Peptide GPCRs Pathway Diagram
Diseases associated with anti-AVPR2 antibodyOrgans/Tissues associated with anti-AVPR2 antibody
 Disease Name  Pubmed Publications
 Diabetes insipidus, nephrogenic, X-linked Antibodies  >76 publications with AVPR2 and Diabetes insipidus, nephrogenic, X-linked
 Diabetes Insipidus, Nephrogenic Antibodies  >76 publications with AVPR2 and Diabetes Insipidus, Nephrogenic
 Kidney Diseases Antibodies  >73 publications with AVPR2 and Kidney Diseases
 Polyuria Antibodies  >19 publications with AVPR2 and Polyuria
 Genetic Diseases, X-Linked Antibodies  >8 publications with AVPR2 and Genetic Diseases, X-Linked
 Growth Disorders Antibodies  >2 publications with AVPR2 and Growth Disorders
 Inflammation Antibodies  >1 publications with AVPR2 and Inflammation
 Hypertension Antibodies  >1 publications with AVPR2 and Hypertension
 Hypercalcemia Antibodies  >1 publications with AVPR2 and Hypercalcemia
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >1 publications with AVPR2 and Lung
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