AAB31735.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
93,383 Da
NCBI Official Full Name
very low density lipoprotein receptor
NCBI Official Synonym Full Names
very low density lipoprotein receptor
NCBI Official Synonym Symbols
CAMRQ1; CARMQ1; CHRMQ1; VLDL-R; VLDLRCH [Similar Products]
NCBI Protein Information
very low-density lipoprotein receptor
UniProt Protein Name
Very low-density lipoprotein receptor
UniProt Synonym Gene Names
NCBI Summary for VLDLR
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. [provided by RefSeq, Aug 2009]
UniProt Comments for VLDLR
VLDLR: Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation. Defects in VLDLR are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 1 (CMARQ1); also known as dysequilibrium syndrome (DES) or non- progressive cerebellar disorder with mental retardation. CMARQ1 is a congenital, non-progressive cerebellar ataxia associated with disturbed equilibrium, delayed ambulation, mental retardation and cerebellar hypoplasia. Additional features include short stature, strabismus, pes planus and, rarely, seizures. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 9p24.2
Cellular Component: membrane; plasma membrane; receptor complex
Molecular Function: apolipoprotein binding; calcium-dependent protein binding; glycoprotein binding; low-density lipoprotein receptor activity; protein binding; very-low-density lipoprotein binding; very-low-density lipoprotein receptor activity
Biological Process: memory; negative regulation of transcription from RNA polymerase II promoter; nervous system development; receptor-mediated endocytosis; signal transduction
Disease: Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome 1
Research Articles on VLDLR
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Products associated with anti-VLDLR antibody
Pathways associated with anti-VLDLR antibody
Diseases associated with anti-VLDLR antibody
Organs/Tissues associated with anti-VLDLR antibody
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