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anti-VTN antibody :: Rabbit anti-Human Vitronectin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS315818 anti-VTN antibody
Unit / Price
1 mg  /  $715 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Vitronectin (VTN), Polyclonal Antibody

 Also Known As   

Rabbit anti Vitronectin

 Product Synonym Names    Rabbit Antibody to Human Vitronectin
 Product Gene Name   

anti-VTN antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000017.10 (26694298..26697373, complement). Location: 17q11
 OMIM    193190
 3D Structure    ModBase 3D Structure for P04004
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Vitronectin
Reacts with both native monomeric and polymeric vitronectin in various tissues and plasma.
 Purity/Purification    >98% pure (SDS-PAGE). Protein A chromatography.
 Form/Format    Purified, Liquid
 Concentration    6.19mg/ml (OD280nm, E^0.1% = 1.36) (lot specific)
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 Immunogen    Native human vitronectin
 Buffer    0.05M Sodium phosphate, pH 6.6 containing 0.1M Sodium chloride, 1mM EDTA
 Preservative    No
 Important Note    Centrifuge before opening to ensure complete recovery of vial contents.
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 Preparation and Storage    Store at -70 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-VTN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-VTN antibody    Polyclonal Antibodies to Platelets and Hemostasis Antigens
 Applications Tested/Suitable for anti-VTN antibody   

EIA/ELISA, Western Blot

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NCBI/Uniprot data below describe general gene information for VTN. It may not necessarily be applicable to this product.
 NCBI GI #    14326449
 NCBI GeneID    7448
 NCBI Accession #    AAK60270.1 [Other Products]
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 UniProt Primary Accession #    P04004 [Other Products]
 UniProt Secondary Accession #    P01141; Q9BSH7; B2R7G0 [Other Products]
 UniProt Related Accession #    P04004 [Other Products]
 Molecular Weight    54,306 Da [Similar Products]
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 NCBI Official Full Name    vitronectin
 NCBI Official Synonym Full Names    vitronectin
 NCBI Official Symbol    VTN [Similar Products]
 NCBI Official Synonym Symbols   
VN; V75; VNT
[Similar Products]
 NCBI Protein Information    vitronectin; epibolin; S-protein; somatomedin B; OTTHUMP00000163323; complement S-protein; serum spreading factor; serum-spreading factor
 UniProt Protein Name    Vitronectin
 UniProt Synonym Protein Names   
S-protein; Serum-spreading factor; V75
 Protein Family    Vitronectin
 UniProt Gene Name    VTN [Similar Products]
 UniProt Entry Name    VTNC_HUMAN
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 NCBI Summary for VTN    The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. [provided by RefSeq]
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 UniProt Comments for VTN    Function: Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity.

Subunit structure: Exists in two forms: a single chain 75 kDa form (V75) and a clipped form composed of two chains (65 kDa and 10 kDa) (V65+V10) which are held together by a disulfide bond. Interacts with SERPINE1/PAI1 and insulin. Ref.9 Ref.10 Ref.15

Subcellular location: Secreted › extracellular space.

Tissue specificity: Plasma. Ref.25

Domain: The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin.

Post-translational modification: Sulfated on 2 tyrosine residues.N- and O-glycosylated

By similarity. Ref.18 Ref.19 Ref.22 Ref.24Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading.It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.Phosphorylation sites are present in the extracelllular medium.

Sequence similarities: Contains 4 hemopexin-like domains.Contains 1 SMB (somatomedin-B) domain.
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Product References and Citations for anti-VTN antibody

   Preissner KT, Reuning U. Vitronectin in vascular context: facets of a multitalented matricellular protein. Semin Thromb Hemost. 2011 Jun;37(4):408-24.
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 Research Articles on VTN    1. PAI-2 is capable of inhibiting uPA in the presence of PAI-1, particularly on adherent cells in the presence of vitronectin
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-VTN antibodyPathways associated with anti-VTN antibody
 Reference Product  PubMed Publications
 SERPINE1 antibody  >3 publications with VTN and SERPINE1
 PLAUR antibody  >2 publications with VTN and PLAUR
 ITGB3 antibody  >1 publications with VTN and ITGB3
 Products by Pathway  Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Inflammatory Response Pathway antibodies  Inflammatory Response Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 Integrins In Angiogenesis Pathway antibodies  Integrins In Angiogenesis Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram
Diseases associated with anti-VTN antibodyOrgans/Tissues associated with anti-VTN antibody
 Disease Name  Pubmed Publications
 Drug Toxicity Antibodies  >2 publications with VTN and Drug Toxicity
 Thyroid Diseases Antibodies  >1 publications with VTN and Thyroid Diseases
 Hypertension, Portal Antibodies  >1 publications with VTN and Hypertension, Portal
 Stroke Antibodies  >1 publications with VTN and Stroke
 Vascular Malformations Antibodies  >1 publications with VTN and Vascular Malformations
 Hypertension Antibodies  >1 publications with VTN and Hypertension
 Common Cold Antibodies  >1 publications with VTN and Common Cold
 Heart Defects, Congenital Antibodies  >1 publications with VTN and Heart Defects, Congenital
 Carcinoma Antibodies  >1 publications with VTN and Carcinoma
 Thyroid Neoplasms Antibodies  >1 publications with VTN and Thyroid Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >13 publications with VTN and Brain
 Blood Antibodies  >6 publications with VTN and Blood
 Heart Antibodies  >4 publications with VTN and Heart
 Kidney Antibodies  >2 publications with VTN and Kidney
 Eye Antibodies  >2 publications with VTN and Eye
 Placenta Antibodies  >2 publications with VTN and Placenta
 Uterus Antibodies  >1 publications with VTN and Uterus
 Ovary Antibodies  >1 publications with VTN and Ovary
 Embryonic Tissue Antibodies  >1 publications with VTN and Embryonic Tissue
 Lung Antibodies  >1 publications with VTN and Lung
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