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anti-vWF antibody :: Rabbit anti-Mouse Von Willebrand Factor (vWF) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2004647 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Western Blot (WB)
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.02 mg  /  $130 +1 FREE 8GB USB
0.05 mg  /  $175 +1 FREE 8GB USB
0.1 mg  /  $230 +1 FREE 8GB USB
0.2 mg  /  $345 +1 FREE 8GB USB
1 mg  /  $815 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Von Willebrand Factor (vWF), Polyclonal Antibody

★Popular Item★
 Also Known As   

Biotin-Linked Antibody to Von Willebrand Factor (vWF)

 Product Gene Name   

anti-vWF antibody

[Similar Products]
 Matching Pairs    Unconjugated Antibody: Von Willebrand Factor (vWF) (MBS2007285)
Biotin Conjugated Antibody: Von Willebrand Factor (vWF) (MBS2004647)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 12; NC_000012.11 (6058040..6233836, complement). Location: 12p13.3
 OMIM    193400
 3D Structure    ModBase 3D Structure for P04275
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Mouse
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 Purity/Purification    Antigen-specific Affinity Chromatography
 Form/Format    Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol
 Concentration    200g/mL (lot specific)
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 Source    Antibody labeling
 Label    Biotin
 Traits    Liquid
 Immunogen    Recombinant vWF (Asp1498~Val1665) expressed in E.coli.
 Unconjugated Antibody    The unconjugated antibody version of this item is also available as catalog #MBS2007285
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 4C for frequent use.
Aliquot and store at -20C for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-vWF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-vWF antibody    Biotin Antibody
 Applications Tested/Suitable for anti-vWF antibody   

WB; IHC; ICC

 Application Notes for anti-vWF antibody    Western blotting: 0.5-2g/mL
Immunohistochemistry: 5-20g/mL
Immunocytochemistry: 5-20g/mL

Optimal working dilutions must be determined by end user
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 Western Blot (WB) of anti-vWF antibody    (Figure. Western Blot; Sample: Recombinant protein.)
anti-vWF antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for vWF. It may not necessarily be applicable to this product.
 NCBI GI #    89191868
 NCBI GeneID    7450
 NCBI Accession #    NP_000543.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000552.3 [Other Products]
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 UniProt Primary Accession #    P04275 [Other Products]
 UniProt Secondary Accession #    Q99806 [Other Products]
 UniProt Related Accession #    P04275 [Other Products]
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 NCBI Official Full Name    von Willebrand factor preproprotein
 NCBI Official Synonym Full Names    von Willebrand factor
 NCBI Official Symbol    VWF [Similar Products]
 NCBI Official Synonym Symbols   
VWD; F8VWF
[Similar Products]
 NCBI Protein Information    von Willebrand factor; coagulation factor VIII VWF
 UniProt Protein Name    von Willebrand factor
 UniProt Synonym Protein Names   
von Willebrand antigen II
 Protein Family    von Willebrand factor
 UniProt Gene Name    VWF [Similar Products]
 UniProt Synonym Gene Names    F8VWF; vWF [Similar Products]
 UniProt Entry Name    VWF_HUMAN
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 NCBI Summary for vWF    The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand's disease. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]
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 UniProt Comments for vWF    VWF: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. Defects in VWF are the cause of von Willebrand disease type 1 (VWD1). A common hemorrhagic disorder due to defects in von Willebrand factor protein and resulting in impaired platelet aggregation. Von Willebrand disease type 1 is characterized by partial quantitative deficiency of circulating von Willebrand factor, that is otherwise structurally and functionally normal. Clinical manifestations are mucocutaneous bleeding, such as epistaxis and menorrhagia, and prolonged bleeding after surgery or trauma. Defects in VWF are the cause of von Willebrand disease type 2 (VWD2). A hemorrhagic disorder due to defects in von Willebrand factor protein and resulting in impaired platelet aggregation. Von Willebrand disease type 2 is characterized by qualitative deficiency and functional anomalies of von Willebrand factor. It is divided in different subtypes including 2A, 2B, 2M and 2N (Normandy variant). The mutant VWF protein in types 2A, 2B and 2M are defective in their platelet- dependent function, whereas the mutant protein in type 2N is defective in its ability to bind factor VIII. Clinical manifestations are mucocutaneous bleeding, such as epistaxis and menorrhagia, and prolonged bleeding after surgery or trauma. Defects in VWF are the cause of von Willebrand disease type 3 (VWD3). A severe hemorrhagic disorder due to a total or near total absence of von Willebrand factor in the plasma and cellular compartments, also leading to a profound deficiency of plasmatic factor VIII. Bleeding usually starts in infancy and can include epistaxis, recurrent mucocutaneous bleeding, excessive bleeding after minor trauma, and hemarthroses.

Protein type: Secreted, signal peptide; Cell adhesion; Motility/polarity/chemotaxis; Secreted; Extracellular matrix

Chromosomal Location of Human Ortholog: 12p13.3

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; endoplasmic reticulum; extracellular region; external side of plasma membrane

Molecular Function: integrin binding; collagen binding; identical protein binding; protein binding; protein homodimerization activity; protease binding; chaperone binding; protein N-terminus binding; immunoglobulin binding; glycoprotein binding

Biological Process: platelet activation; extracellular matrix organization and biogenesis; platelet degranulation; hemostasis; response to wounding; liver development; blood coagulation; cell adhesion; blood coagulation, intrinsic pathway; protein homooligomerization; cell-substrate adhesion; placenta development

Disease: Von Willebrand Disease, Type 3; Von Willebrand Disease, Type 1; Von Willebrand Disease, Type 2
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 Research Articles on vWF    1. a new function for VWF in vivo as regulator of bloodstream thrombopoiesis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-vWF antibodyPathways associated with anti-vWF antibody
 Reference Product  PubMed Publications
 ADAMTS13 antibody  >564 publications with vWF and ADAMTS13
 VEGFA antibody  >42 publications with vWF and VEGFA
 GP1BA antibody  >15 publications with vWF and GP1BA
 ITGA2B antibody  >7 publications with vWF and ITGA2B
 GATA2 antibody  >1 publications with vWF and GATA2
 Products by Pathway  Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
Diseases associated with anti-vWF antibodyOrgans/Tissues associated with anti-vWF antibody
 Disease Name  Pubmed Publications
 Vascular Diseases Antibodies  >1893 publications with vWF and Vascular Diseases
 Cardiovascular Diseases Antibodies  >1871 publications with vWF and Cardiovascular Diseases
 Thrombosis Antibodies  >1341 publications with vWF and Thrombosis
 Heart Diseases Antibodies  >590 publications with vWF and Heart Diseases
 Inflammation Antibodies  >549 publications with vWF and Inflammation
 Neoplasms Antibodies  >431 publications with vWF and Neoplasms
 Atherosclerosis Antibodies  >348 publications with vWF and Atherosclerosis
 Kidney Diseases Antibodies  >308 publications with vWF and Kidney Diseases
 Hypertension Antibodies  >278 publications with vWF and Hypertension
 Necrosis Antibodies  >253 publications with vWF and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5600 publications with vWF and Blood
 Vascular Antibodies  >2830 publications with vWF and Vascular
 Heart Antibodies  >595 publications with vWF and Heart
 Muscle Antibodies  >344 publications with vWF and Muscle
 Bone Antibodies  >304 publications with vWF and Bone
 Kidney Antibodies  >288 publications with vWF and Kidney
 Liver Antibodies  >250 publications with vWF and Liver
 Umbilical Cord Antibodies  >247 publications with vWF and Umbilical Cord
 Brain Antibodies  >241 publications with vWF and Brain
 Skin Antibodies  >229 publications with vWF and Skin
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