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anti-VPRBP antibody :: Rabbit Vpr (HIV-1) binding protein Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS713791 anti-VPRBP antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Vpr (HIV-1) binding protein (VPRBP), Polyclonal Antibody

 Also Known As   

Rabbit anti-human Vpr (HIV-1) binding protein polyclonal Antibody

 Product Synonym Names    Vpr (HIV-1) binding protein; VPRBP; DCAF1; KIAA0800; MGC102804
 Product Gene Name   

anti-VPRBP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human VPRBP
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-82419 / sc-98531
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-VPRBP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-VPRBP antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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NCBI/Uniprot data below describe general gene information for VPRBP. It may not necessarily be applicable to this product.
 NCBI GI #    119585547
 NCBI GeneID    9730
 NCBI Accession #    EAW65143.1 [Other Products]
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 UniProt Secondary Accession #    Q2YD74; Q8TBD9; Q9HCA1; Q9UG37 [Other Products]
 UniProt Related Accession #    Q9Y4B6 [Other Products]
 Molecular Weight    118,235 Da [Similar Products]
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 NCBI Official Full Name    Vpr (HIV-1) binding protein, isoform CRA_d
 NCBI Official Synonym Full Names    Vpr (HIV-1) binding protein
 NCBI Official Symbol    VPRBP [Similar Products]
 NCBI Official Synonym Symbols   
DCAF1
[Similar Products]
 NCBI Protein Information    protein VPRBP; Vpr-binding protein; vpr-interacting protein; HIV-1 Vpr-binding protein; DDB1 and CUL4 associated factor 1; DDB1- and CUL4-associated factor 1; serine/threonine-protein kinase VPRBP
 UniProt Protein Name    Protein VPRBP
 UniProt Synonym Protein Names   
DDB1- and CUL4-associated factor 1; HIV-1 Vpr-binding protein; VprBP; Serine/threonine-protein kinase VPRBP (EC:2.7.11.1); Vpr-interacting protein
 Protein Family    Protein
 UniProt Gene Name    VPRBP [Similar Products]
 UniProt Synonym Gene Names    DCAF1; KIAA0800; RIP; VprBP [Similar Products]
 UniProt Entry Name    VPRBP_HUMAN
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 UniProt Comments for VPRBP    VPRBP: Component of the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex, VprBP/DCAF1 may function as the substrate recognition module within this complex. For example, VprBP/DCAF1 targets NF2 to the E3 ubiquitin-ligase complex for ubiquitination and subsequent proteasome-dependent degradation. In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the CUL4A-RBX1-DDB1 function leading to arrest the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase. In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the CUL4A-RBX1-DDB1 function leading to enhanced efficiency of macrophage infection and promotion of the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage. Associated with chromatin in a DDB1-independent and cell cycle-dependent manner, VprBP/DCAF1 is recruited to chromatin as DNA is being replicated and is released from chromatin before mitosis. Belongs to the VPRBP/DCAF1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system; EC 2.7.11.1

Chromosomal Location of Human Ortholog: 3p21.2

Cellular Component: signalosome; cytoplasm; nucleolus; nucleus

Molecular Function: protein binding; ATP binding

Biological Process: V(D)J recombination; transcription, DNA-dependent; viral reproduction; B cell differentiation; cell competition in a multicellular organism; protein ubiquitination; negative regulation of transcription from RNA polymerase II promoter
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 Research Articles on VPRBP    1. The predicted beta-propeller conformation of DCAF1 is likely to be critical for Vpr association.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-VPRBP antibodyPathways associated with anti-VPRBP antibody
 Reference Product  PubMed Publications
 DDB1 antibody  >32 publications with VPRBP and DDB1
 CUL4A antibody  >23 publications with VPRBP and CUL4A
 SAMHD1 antibody  >5 publications with VPRBP and SAMHD1
 NF2 antibody  >4 publications with VPRBP and NF2
 CUL4B antibody  >2 publications with VPRBP and CUL4B
 CCNO antibody  >2 publications with VPRBP and CCNO
 COPS6 antibody  >1 publications with VPRBP and COPS6
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
Diseases associated with anti-VPRBP antibodyOrgans/Tissues associated with anti-VPRBP antibody
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >10 publications with VPRBP and Immune System Diseases
 Immunologic Deficiency Syndromes Antibodies  >10 publications with VPRBP and Immunologic Deficiency Syndromes
 Congenital Abnormalities Antibodies  >2 publications with VPRBP and Congenital Abnormalities
 Cell Transformation, Neoplastic Antibodies  >1 publications with VPRBP and Cell Transformation, Neoplastic
 Adenoma Antibodies  >1 publications with VPRBP and Adenoma
 Mesothelioma Antibodies  >1 publications with VPRBP and Mesothelioma
 Breast Neoplasms Antibodies  >1 publications with VPRBP and Breast Neoplasms
 Necrosis Antibodies  >1 publications with VPRBP and Necrosis
 Nervous System Malformations Antibodies  >1 publications with VPRBP and Nervous System Malformations
 Adenocarcinoma Antibodies  >1 publications with VPRBP and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with VPRBP and Blood
 Kidney Antibodies  >2 publications with VPRBP and Kidney
 Nerve Antibodies  >1 publications with VPRBP and Nerve
 Embryonic Tissue Antibodies  >1 publications with VPRBP and Embryonic Tissue
 Lung Antibodies  >1 publications with VPRBP and Lung
 Ovary Antibodies  >1 publications with VPRBP and Ovary
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