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anti-WASF1 antibody :: Rabbit WASF1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7053165
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

WASF1, Polyclonal Antibody

★Popular Item★
 Also Known As   

WASF1 Antibody

 Product Synonym Names    Wiskott-Aldrich syndrome protein family member 1; WASP family protein member 1; Protein WAVE-1; Verprolin homology domain-containing protein 1; WASF1; KIAA0269; SCAR1; WAVE1
 Product Gene Name   

anti-WASF1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AF134303 mRNA
 3D Structure    ModBase 3D Structure for Q92558
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant Human Wiskott-Aldrich syndrome protein family member 1 protein (381-553AA)
 Conjugation    Non-conjugated
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, pH 7.4
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-WASF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-WASF1 antibody

   Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
 Applications Tested/Suitable for anti-WASF1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-WASF1 antibody    WB: 1:500-1:5000
IHC: 1:20-1:200
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 Western Blot (WB) of anti-WASF1 antibody    Western Blot
Positive WB detected in: Rat brain tissue,Mouse brain tissue
All lanes: WASF1 antibody at 3ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 62 KDa
Observed band size: 62 KDa

anti-WASF1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-WASF1 antibody    Immunohistochemistry of paraffin-embedded human colon cancer using MBS7053165 at dilution of 1:100
anti-WASF1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-WASF1 antibody    Immunohistochemistry of paraffin-embedded human cervical cancer using MBS7053165 at dilution of 1:100
anti-WASF1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for WASF1. It may not necessarily be applicable to this product.
 NCBI GI #    68161500
 NCBI GeneID    8936
 NCBI Accession #    NP_001020105.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001024934.1 [Other Products]
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 UniProt Primary Accession #    Q92558 [Other Products]
 UniProt Secondary Accession #    Q5SZK7; E1P5F2 [Other Products]
 UniProt Related Accession #    Q92558 [Other Products]
 Molecular Weight    61,652 Da
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 NCBI Official Full Name    wiskott-Aldrich syndrome protein family member 1
 NCBI Official Synonym Full Names    WAS protein family member 1
 NCBI Official Symbol    WASF1 [Similar Products]
 NCBI Official Synonym Symbols   
WAVE; SCAR1; WAVE1
[Similar Products]
 NCBI Protein Information    wiskott-Aldrich syndrome protein family member 1
 UniProt Protein Name    Wiskott-Aldrich syndrome protein family member 1
 UniProt Synonym Protein Names   
Protein WAVE-1; Verprolin homology domain-containing protein 1
 Protein Family    Wiskott-Aldrich syndrome protein family
 UniProt Gene Name    WASF1 [Similar Products]
 UniProt Synonym Gene Names    KIAA0269; SCAR1; WAVE1; WASP family protein member 1 [Similar Products]
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 NCBI Summary for WASF1    The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for WASF1    WAVE1: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Belongs to the SCAR/WAVE family.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 6q21

Cellular Component: actin cytoskeleton; cytoskeleton

Molecular Function: protein binding; protein complex binding; Rac GTPase binding

Biological Process: actin filament polymerization; cell motility; Rac protein signal transduction
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 Research Articles on WASF1    1. Results implicate a contributory role of WAVE1 and -3 to the metastatic phenotype of PC-3 cells through their interaction with the ARP2/3 complex.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-WASF1 antibodyPathways associated with anti-WASF1 antibody
 Reference Product  PubMed Publications
 CDC42 antibody  >14 publications with WASF1 and CDC42
 ACTR2 antibody  >13 publications with WASF1 and ACTR2
 RAC1 antibody  >7 publications with WASF1 and RAC1
 ABI1 antibody  >5 publications with WASF1 and ABI1
 PFN1 antibody  >2 publications with WASF1 and PFN1
 CDK5 antibody  >2 publications with WASF1 and CDK5
 NCK1 antibody  >1 publications with WASF1 and NCK1
 GRB2 antibody  >1 publications with WASF1 and GRB2
 CRK antibody  >1 publications with WASF1 and CRK
 BAD antibody  >1 publications with WASF1 and BAD
 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 E2F Transcription Factor Network Pathway antibodies  E2F Transcription Factor Network Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway antibodies  Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
Diseases associated with anti-WASF1 antibodyOrgans/Tissues associated with anti-WASF1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >15 publications with WASF1 and Neoplasms
 Immune System Diseases Antibodies  >8 publications with WASF1 and Immune System Diseases
 Blood Coagulation Disorders Antibodies  >6 publications with WASF1 and Blood Coagulation Disorders
 Nervous System Diseases Antibodies  >5 publications with WASF1 and Nervous System Diseases
 Brain Diseases Antibodies  >3 publications with WASF1 and Brain Diseases
 Neoplasms, Experimental Antibodies  >2 publications with WASF1 and Neoplasms, Experimental
 Abnormalities, Multiple Antibodies  >2 publications with WASF1 and Abnormalities, Multiple
 Genital Diseases, Male Antibodies  >1 publications with WASF1 and Genital Diseases, Male
 Disease Models, Animal Antibodies  >1 publications with WASF1 and Disease Models, Animal
 Prostatic Diseases Antibodies  >1 publications with WASF1 and Prostatic Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >14 publications with WASF1 and Brain
 Nerve Antibodies  >8 publications with WASF1 and Nerve
 Blood Antibodies  >7 publications with WASF1 and Blood
 Muscle Antibodies  >4 publications with WASF1 and Muscle
 Lung Antibodies  >2 publications with WASF1 and Lung
 Bone Antibodies  >2 publications with WASF1 and Bone
 Stomach Antibodies  >1 publications with WASF1 and Stomach
 Skin Antibodies  >1 publications with WASF1 and Skin
 Intestine Antibodies  >1 publications with WASF1 and Intestine
 Kidney Antibodies  >1 publications with WASF1 and Kidney
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