NP_001188333.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
31,979 Da
NCBI Official Full Name
wiskott-Aldrich syndrome protein family member 2 isoform 2
NCBI Official Synonym Full Names
WAS protein family member 2
NCBI Official Synonym Symbols
IMD2; SCAR2; WASF4; WAVE2; dJ393P12.2 [Similar Products]
NCBI Protein Information
wiskott-Aldrich syndrome protein family member 2
UniProt Protein Name
Wiskott-Aldrich syndrome protein family member 2
UniProt Synonym Protein Names
Protein WAVE-2; Verprolin homology domain-containing protein 2
UniProt Synonym Gene Names
UniProt Entry Name
WASF2_HUMAN
UniProt Comments for WASF2
WAVE2: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. Directly interacts with BRK1. Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle. Belongs to the SCAR/WAVE family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1p36.11
Cellular Component: actin cytoskeleton; cell-cell adherens junction; cytosol; intracellular; lamellipodium
Molecular Function: protein binding; protein complex binding; SH3 domain binding
Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; negative regulation of stress fiber formation; vascular endothelial growth factor receptor signaling pathway
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Products associated with anti-WASF2 antibody
Pathways associated with anti-WASF2 antibody
Diseases associated with anti-WASF2 antibody
Organs/Tissues associated with anti-WASF2 antibody
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