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anti-WASF2 antibody :: Rabbit WAVE2 (Central region) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS472070
Testing Data
Unit / Price
0.1 mL  /  $280 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

WAVE2 (Central region) (WASF2), Polyclonal Antibody

 Also Known As   

WAVE2 (Central region)

 Product Synonym Names    Wiskott-Aldrich syndrome verproline-homologous protein 2; Scar2; WASF2
 Product Gene Name   

anti-WASF2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (27732126..27816669, complement). Location: 1p36.11
 3D Structure    ModBase 3D Structure for Q05BU7
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Rat, Mouse
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 Specificity    This antibody was affinity purified using WAVE2 (Central region) peptide (without carrier). The antibody detects a 78 kDa* protein corresponding to the molecular mass of WAVE2 on SDS-PAGE immunoblots of rat PC12 cells.
 Purity/Purification    Affinity Purified
 Form/Format    Rabbit polyclonal, affinity-purified antibody is supplied in 100 ul phosphate-buffered saline, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide.
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 Immunogen    A synthetic peptide (coupled to KLH) corresponding to amino acid residues in the central region of human WAVE2. This sequence has high homology with similar regions in rat and mouse WAVE2, and has low homology to similar regions in WAVE1 and WAVE3.
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 Preparation and Storage    Store at -20 degree C. Do not aliquot. Stable for 1 year.
 Other Notes    Small volumes of anti-WASF2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-WASF2 antibody

   The Wiskott-Aldrich syndrome protein (WASP) family is involved in various pathways that regulate actin cytoskeletal organization. This family includes WASP, N-WASP, and three WAVE/SCAR isoforms, WAVEs 1, 2, and 3. WAVE proteins play key roles in actin-mediated cell events, such as membrane ruffling and lamellipodia formation. WAVEs contain an Nterminal WAVE homology domain, a basic domain, a Proline-rich region, and carboxy terminal verprolin, cofilin, and acidic (VCA) region. WAVEs are thought to act downstream of the Rac GTPase, connecting Rac activation to induction of Arp 2/3-mediated actin polymerization. Regulation of WAVE activity can occur through tyrosine phosphorylation. Src phosphorylation of WAVE1 at Tyr-125 enhances binding to the Arp2/3 complex, and is required for WAVE inhibition of Arp2/3-mediated stress fiber formation. By contrast, WAVE2 phosphorylation of Tyr-150 by Abl may enhance Arp2/3 complex actin nucleation and microspike formation in fibroblasts. Thus, site-specific tyrosine phosphorylation may be important for controlling specific activities of WAVE proteins.
 Applications Tested/Suitable for anti-WASF2 antibody   

ELISA, Western Blot

 Application Notes for anti-WASF2 antibody    ELISA: 1:2000
Western Blot: 1:1000
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 Testing Data of anti-WASF2 antibody    anti-WASF2 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for WASF2. It may not necessarily be applicable to this product.
 NCBI GI #    319655728
 NCBI GeneID    10163
 NCBI Accession #    NP_001188333.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001201404.1 [Other Products]
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 UniProt Primary Accession #    Q05BU7 [Other Products]
 UniProt Related Accession #    Q05BU7; Q8NBU0; Q9Y6W5 [Other Products]
 Molecular Weight    21,410 Da [Similar Products]
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 NCBI Official Full Name    wiskott-Aldrich syndrome protein family member 2 isoform 2
 NCBI Official Synonym Full Names    WAS protein family, member 2
 NCBI Official Symbol    WASF2 [Similar Products]
 NCBI Official Synonym Symbols   
SCAR2; WAVE2; dJ393P12.2
[Similar Products]
 NCBI Protein Information    wiskott-Aldrich syndrome protein family member 2; IMD2; protein WAVE-2; OTTHUMP00000003471; WASP family protein member 2; WASP family Verprolin-homologous protein 2; verprolin homology domain-containing protein 2; suppressor of cyclic-AMP receptor (WASP-family)
 UniProt Protein Name    WASF2 protein
 Protein Family    Wiskott-Aldrich syndrome protein family
 UniProt Gene Name    WASF2 [Similar Products]
 UniProt Entry Name    Q05BU7_HUMAN
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 NCBI Summary for WASF2    This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
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 UniProt Comments for WASF2    WAVE2: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. Directly interacts with BRK1. Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle. Belongs to the SCAR/WAVE family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Actin-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: ruffle; lamellipodium; early endosome; intracellular; intercellular junction; cytosol; actin cytoskeleton

Molecular Function: protein binding; protein complex binding; actin binding

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; lamellipodium biogenesis; negative regulation of stress fiber formation; actin filament-based movement; ameboidal cell migration; innate immune response; Rac protein signal transduction; angiogenesis; actin cytoskeleton organization and biogenesis; vascular endothelial growth factor receptor signaling pathway
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Product References and Citations for anti-WASF2 antibody

   • Ardern, H. et al. (2006) Cell Motil. Cytosk. 63:6.
• Leng, Y. et al. (2005) PNAS 102(4):1098.
• Suetsugu, S. et al. (1999) Bioch. Biophs. Res. Comm. 260:296.
• Miki, H. et al. (1999) J Biol. Chem. 274(39):27605.
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 Research Articles on WASF2    1. WAVE2 and WASp define parallel pathways to F-actin reorganization and function in NK cells; although WAVE2 was not required for NK cell innate function, it was accessible through adaptive immunity via IL-2.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-WASF2 antibodyPathways associated with anti-WASF2 antibody
 Reference Product  PubMed Publications
 CDC42 antibody  >12 publications with WASF2 and CDC42
 ABI1 antibody  >10 publications with WASF2 and ABI1
 BAIAP2 antibody  >6 publications with WASF2 and BAIAP2
 ACTR2 antibody  >6 publications with WASF2 and ACTR2
 ACTR3 antibody  >2 publications with WASF2 and ACTR3
 ABI2 antibody  >2 publications with WASF2 and ABI2
 NCKAP1 antibody  >1 publications with WASF2 and NCKAP1
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Diseases associated with anti-WASF2 antibody
 Disease Name  Pubmed Publications
 Melanoma Antibodies  >5 publications with WASF2 and Melanoma
 Skin Diseases Antibodies  >4 publications with WASF2 and Skin Diseases
 Neoplasms, Experimental Antibodies  >4 publications with WASF2 and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >4 publications with WASF2 and Breast Neoplasms
 Lung Diseases Antibodies  >3 publications with WASF2 and Lung Diseases
 Nervous System Diseases Antibodies  >3 publications with WASF2 and Nervous System Diseases
 Adenocarcinoma Antibodies  >3 publications with WASF2 and Adenocarcinoma
 Leukopenia Antibodies  >2 publications with WASF2 and Leukopenia
 Liver Diseases Antibodies  >2 publications with WASF2 and Liver Diseases
 Hematologic Diseases Antibodies  >2 publications with WASF2 and Hematologic Diseases
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