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anti-WASF2 antibody :: Rabbit anti-Human, Rat WAVE2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS610176 anti-WASF2 antibody
Unit / Price
0.2 mL  /  $680 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

WAVE2 (WASF2), Polyclonal Antibody

 Also Known As   

WAVE2 (Scar2)

 Product Synonym Names    Anti -WAVE2 (Scar2)
 Product Gene Name   

anti-WASF2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (27732126..27816669, complement). Location: 1p36.11
 3D Structure    ModBase 3D Structure for Q05BU7
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Rat
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 Specificity    Recognizes human WAVE2/Scar2, Mr ~68kD. An additional band, Mr ~64kD, is observed with longer exposures or when loading larger amounts of cell lysate. This band is not inhibited with the immunizing peptide. Species Crossreactivity: rat.
 Purity/Purification    Serum
Serum
 Form/Format    Supplied as a liquid in 0.05% sodium azide, before the addition of glycerol to 30%.
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 Immunogen    Synthetic peptide corresponding to aa186-200 (C-NRGNVNPRKIKTRKE) of human WAVE2/Scar2 (KLH).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-WASF2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-WASF2 antibody

   Scar/WAVE, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold.
 Product Categories/Family for anti-WASF2 antibody    Antibodies; Abs to Disease Markers
 Applications Tested/Suitable for anti-WASF2 antibody   

Western Blot (WB)

 Application Notes for anti-WASF2 antibody    Suitable for use in Western Blot.
Dilution: Western Blot: 1:500-1:2000 of this lot detected WAVE2/Scar2 in RIPA lysates from HL60 cells. HL60 cell lysate was resolved by electrophoresis, transferred to nitrocellulose and probed with W0951 (1:1000). Proteins were visualized using a goat anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence detection system.
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NCBI/Uniprot data below describe general gene information for WASF2. It may not necessarily be applicable to this product.
 NCBI GI #    319655728
 NCBI GeneID    10163
 NCBI Accession #    NP_001188333.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001201404.1 [Other Products]
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 UniProt Primary Accession #    Q05BU7 [Other Products]
 UniProt Related Accession #    Q05BU7; Q8NBU0; Q9Y6W5 [Other Products]
 Molecular Weight    21,410 Da [Similar Products]
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 NCBI Official Full Name    wiskott-Aldrich syndrome protein family member 2 isoform 2
 NCBI Official Synonym Full Names    WAS protein family, member 2
 NCBI Official Symbol    WASF2 [Similar Products]
 NCBI Official Synonym Symbols   
SCAR2; WAVE2; dJ393P12.2
[Similar Products]
 NCBI Protein Information    wiskott-Aldrich syndrome protein family member 2; IMD2; protein WAVE-2; OTTHUMP00000003471; WASP family protein member 2; WASP family Verprolin-homologous protein 2; verprolin homology domain-containing protein 2; suppressor of cyclic-AMP receptor (WASP-family)
 UniProt Protein Name    WASF2 protein
 Protein Family    Wiskott-Aldrich syndrome protein family
 UniProt Gene Name    WASF2 [Similar Products]
 UniProt Entry Name    Q05BU7_HUMAN
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 NCBI Summary for WASF2    This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
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 UniProt Comments for WASF2    WAVE2: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. Directly interacts with BRK1. Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle. Belongs to the SCAR/WAVE family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Actin-binding

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: ruffle; lamellipodium; early endosome; intracellular; intercellular junction; cytosol; actin cytoskeleton

Molecular Function: protein binding; protein complex binding; actin binding

Biological Process: lamellipodium biogenesis; G-protein signaling, coupled to cAMP nucleotide second messenger; negative regulation of stress fiber formation; actin filament-based movement; ameboidal cell migration; Rac protein signal transduction; innate immune response; angiogenesis; actin cytoskeleton organization and biogenesis; vascular endothelial growth factor receptor signaling pathway
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 Research Articles on WASF2    1. WAVE2 and WASp define parallel pathways to F-actin reorganization and function in NK cells; although WAVE2 was not required for NK cell innate function, it was accessible through adaptive immunity via IL-2.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-WASF2 antibodyPathways associated with anti-WASF2 antibody
 Reference Product  PubMed Publications
 CDC42 antibody  >12 publications with WASF2 and CDC42
 ABI1 antibody  >10 publications with WASF2 and ABI1
 BAIAP2 antibody  >6 publications with WASF2 and BAIAP2
 ACTR2 antibody  >6 publications with WASF2 and ACTR2
 ACTR3 antibody  >2 publications with WASF2 and ACTR3
 ABI2 antibody  >2 publications with WASF2 and ABI2
 NCKAP1 antibody  >1 publications with WASF2 and NCKAP1
 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 E-cadherin Signaling In The Nascent Adherens Junction Pathway antibodies  E-cadherin Signaling In The Nascent Adherens Junction Pathway Diagram
 ErbB1 Downstream Signaling Pathway antibodies  ErbB1 Downstream Signaling Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 RAC1 Signaling Pathway antibodies  RAC1 Signaling Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
Diseases associated with anti-WASF2 antibody
 Disease Name  Pubmed Publications
 Melanoma Antibodies  >5 publications with WASF2 and Melanoma
 Skin Diseases Antibodies  >4 publications with WASF2 and Skin Diseases
 Neoplasms, Experimental Antibodies  >4 publications with WASF2 and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >4 publications with WASF2 and Breast Neoplasms
 Lung Diseases Antibodies  >3 publications with WASF2 and Lung Diseases
 Nervous System Diseases Antibodies  >3 publications with WASF2 and Nervous System Diseases
 Adenocarcinoma Antibodies  >3 publications with WASF2 and Adenocarcinoma
 Leukopenia Antibodies  >2 publications with WASF2 and Leukopenia
 Liver Diseases Antibodies  >2 publications with WASF2 and Liver Diseases
 Hematologic Diseases Antibodies  >2 publications with WASF2 and Hematologic Diseases
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