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anti-WRNIP1 antibody :: Goat WHIP/WRNIP1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420165
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

WHIP/WRNIP1, Polyclonal Antibody

 Also Known As   

Goat anti-WHIP/WRNIP1 Antibody

 Product Synonym Names    WHIP; Werner helicase interacting protein; FLJ22526; putative helicase RUVBL; Werner helicase interacting protein 1; RP11-420G6.2; bA420G6.2; WHIP antibody; Werner helicase interacting protein antibody; FLJ22526 antibody; putative helicase RUVBL antibody; Werner helicase interacting protein 1 antibody; RP11-420G6.2 antibody; bA420G6.2 antibody; WHIP / WRNIP1
 Product Gene Name   

anti-WRNIP1 antibody

[Similar Products]
 Product Synonym Gene Name    WHIP [Similar Products]
 Antibody/Peptide Pairs    WHIP / WRNIP1 peptide (MBS426783) is used for blocking the activity of WHIP/WRNIP1 antibody (MBS420165)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    EELRGVDFFK QRRC
 OMIM    608196
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence EELRGVDFFKQRRC, from the C Terminus of the protein sequence according to NP_064520.2; NP_569079.1.
 Epitope    C Terminus
 Note    This antibody is expected to recognise isoform 1 (NP_064520.2) and isoform 2 (NP_569079.1).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-WRNIP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-WRNIP1 antibody   

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-WRNIP1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Immunohistochemistry: In paraffin embedded Human Kidney shows nuclear staining, stronger in DCT compared to PCT. Recommended concentration, 4-6ug/ml.
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 Western Blot (WB) of anti-WRNIP1 antibody    (1ug/ml) staining of Jurkat lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-WRNIP1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-WRNIP1 antibody    (4ug/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining.
anti-WRNIP1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for WRNIP1. It may not necessarily be applicable to this product.
 NCBI GI #    18426902
 NCBI GeneID    56897
 NCBI Accession #    NP_064520.2 [Other Products]
 NCBI Related Accession #    NP_569079.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_020135.2 [Other Products]
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 UniProt Secondary Accession #    Q53EP6; Q59ET8; Q5W0E2; Q5W0E4; Q8WV26; Q9H681; Q9NRJ6; B2RDB0 [Other Products]
 UniProt Related Accession #    Q96S55 [Other Products]
 Molecular Weight    31,339 Da
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 NCBI Official Full Name    ATPase WRNIP1 isoform 1
 NCBI Official Synonym Full Names    Werner helicase interacting protein 1
 NCBI Official Symbol    WRNIP1 [Similar Products]
 NCBI Official Synonym Symbols   
WHIP; bA420G6.2
[Similar Products]
 NCBI Protein Information    ATPase WRNIP1
 UniProt Protein Name    ATPase WRNIP1
 UniProt Synonym Protein Names   
Werner helicase-interacting protein 1
 Protein Family    ATPase
 UniProt Gene Name    WRNIP1 [Similar Products]
 UniProt Entry Name    WRIP1_HUMAN
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 NCBI Summary for WRNIP1    Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012]
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 UniProt Comments for WRNIP1    WRNIP1: a modulator for initiation or restart of DNA polymerase delta-mediated DNA synthesis. Its ATPase activity may sense DNA ends and regulate the extent of polymerase stimulation.

Protein type: Helicase; EC 3.6.1.3

Chromosomal Location of Human Ortholog: 6p25.2

Cellular Component: membrane; nuclear chromosome, telomeric region; nucleus; perinuclear region of cytoplasm

Molecular Function: ATP binding; ATPase activity; DNA binding; identical protein binding; metal ion binding; protein binding

Biological Process: DNA replication; DNA synthesis during DNA repair; regulation of DNA replication initiation
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 Research Articles on WRNIP1    1. results suggest that WRNIP1 functions upstream of Poleta in the response to UV irradiation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-WRNIP1 antibodyDiseases associated with anti-WRNIP1 antibody
 Reference Product  PubMed Publications
 WRN antibody  >11 publications with WRNIP1 and WRN
 RAD18 antibody  >6 publications with WRNIP1 and RAD18
 PCNA antibody  >4 publications with WRNIP1 and PCNA
 BLM antibody  >1 publications with WRNIP1 and BLM
 RECQL antibody  >1 publications with WRNIP1 and RECQL
 Disease Name  Pubmed Publications
 Neurobehavioral Manifestations Antibodies  >1 publications with WRNIP1 and Neurobehavioral Manifestations
 Urogenital Abnormalities Antibodies  >1 publications with WRNIP1 and Urogenital Abnormalities
 Abnormalities, Multiple Antibodies  >1 publications with WRNIP1 and Abnormalities, Multiple
 Neurologic Manifestations Antibodies  >1 publications with WRNIP1 and Neurologic Manifestations
 Inflammation Antibodies  >1 publications with WRNIP1 and Inflammation
Organs/Tissues associated with anti-WRNIP1 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2 publications with WRNIP1 and Blood
 Larynx Antibodies  >1 publications with WRNIP1 and Larynx
 Lung Antibodies  >1 publications with WRNIP1 and Lung
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