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anti-WIF1 antibody :: Rabbit anti-Human WIF1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS627144 anti-WIF1 antibody
Unit / Price
0.2 mL  /  $550 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

WIF1, Polyclonal Antibody

 Also Known As   

WIF1, CT (Wnt Inhibitory Factor 1, WIF-1, UNQ191/PRO217)

 Product Synonym Names    Anti -WIF1, CT (Wnt Inhibitory Factor 1, WIF-1, UNQ191/PRO217)
 Product Gene Name   

anti-WIF1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 12; NC_000012.11 (65444404..65515346, complement). Location: 12q14.3
 OMIM    605186
 3D Structure    ModBase 3D Structure for Q9Y5W5
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Recognizes human WIF1.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in PBS, 0.09% sodium azide.
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 Immunogen    Synthetic peptide selected from the C-term region of human WIF1 (KLH).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-WIF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-WIF1 antibody

   WNT proteins are extracellular signaling molecules involved in the control of embryonic development. WIF1 is a secreted protein, which binds WNT proteins and inhibits their activities. This protein contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. It may be involved in mesoderm segmentation. This protein is found to be present in fish, amphibia and mammals.
 Product Categories/Family for anti-WIF1 antibody    Antibodies; Abs to Binding Proteins
 Applications Tested/Suitable for anti-WIF1 antibody   

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-WIF1 antibody    Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100
Immunohistochemistry: 1:10-1:50
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NCBI/Uniprot data below describe general gene information for WIF1. It may not necessarily be applicable to this product.
 NCBI GI #    111125011
 NCBI GeneID    11197
 NCBI Accession #    NP_009122.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_007191.4 [Other Products]
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 UniProt Primary Accession #    Q9Y5W5 [Other Products]
 UniProt Secondary Accession #    Q6UXI1; Q8WVG4 [Other Products]
 UniProt Related Accession #    Q9Y5W5 [Other Products]
 Molecular Weight    41,528 Da [Similar Products]
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 NCBI Official Full Name    wnt inhibitory factor 1
 NCBI Official Synonym Full Names    WNT inhibitory factor 1
 NCBI Official Symbol    WIF1 [Similar Products]
 NCBI Official Synonym Symbols   
WIF-1
[Similar Products]
 NCBI Protein Information    wnt inhibitory factor 1; OTTHUMP00000239565
 UniProt Protein Name    Wnt inhibitory factor 1
 Protein Family    Wnt inhibitory factor
 UniProt Gene Name    WIF1 [Similar Products]
 UniProt Entry Name    WIF1_HUMAN
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 NCBI Summary for WIF1    The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers. [provided by RefSeq]
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 UniProt Comments for WIF1    WIF1: Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.

Protein type: Secreted; Secreted, signal peptide; Inhibitor

Chromosomal Location of Human Ortholog: 12q14.3

Cellular Component: extracellular region

Molecular Function: protein binding

Biological Process: Wnt receptor signaling pathway; multicellular organismal development; positive regulation of fat cell differentiation; signal transduction
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 Research Articles on WIF1    1. Down-regulation of WIF-1 mRNA expression is associated with hepatocellular carcinoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-WIF1 antibodyDiseases associated with anti-WIF1 antibody
 Products by Pathway  Pathway Diagram
 Presenilin Action In Notch And Wnt Signaling Pathway antibodies  Presenilin Action In Notch And Wnt Signaling Pathway Diagram
 Wnt Signaling Network Pathway antibodies  Wnt Signaling Network Pathway Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >80 publications with WIF1 and Neoplasms
 Carcinoma Antibodies  >36 publications with WIF1 and Carcinoma
 Adenocarcinoma Antibodies  >14 publications with WIF1 and Adenocarcinoma
 Lung Neoplasms Antibodies  >13 publications with WIF1 and Lung Neoplasms
 Colorectal Neoplasms Antibodies  >13 publications with WIF1 and Colorectal Neoplasms
 Head and Neck Neoplasms Antibodies  >11 publications with WIF1 and Head and Neck Neoplasms
 Carcinoma, Squamous Cell Antibodies  >7 publications with WIF1 and Carcinoma, Squamous Cell
 Leukemia Antibodies  >7 publications with WIF1 and Leukemia
 Breast Neoplasms Antibodies  >6 publications with WIF1 and Breast Neoplasms
 Urinary Bladder Neoplasms Antibodies  >6 publications with WIF1 and Urinary Bladder Neoplasms
Organs/Tissues associated with anti-WIF1 antibody
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >20 publications with WIF1 and Bone
 Lung Antibodies  >17 publications with WIF1 and Lung
 Eye Antibodies  >10 publications with WIF1 and Eye
 Brain Antibodies  >9 publications with WIF1 and Brain
 Muscle Antibodies  >7 publications with WIF1 and Muscle
 Skin Antibodies  >6 publications with WIF1 and Skin
 Kidney Antibodies  >6 publications with WIF1 and Kidney
 Liver Antibodies  >5 publications with WIF1 and Liver
 Prostate Antibodies  >5 publications with WIF1 and Prostate
 Mouth Antibodies  >4 publications with WIF1 and Mouth
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