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anti-WAS antibody :: Goat Wiskott-Aldrich Syndrome/WASP Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420239
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Wiskott-Aldrich Syndrome/WASP, Polyclonal Antibody

 Also Known As   

Goat anti-Wiskott-Aldrich Syndrome/WASP Antibody

 Product Synonym Names    WAS; WASP; Wiskott-Aldrich syndrome (eczema-thrombocytopenia); THC; IMD2; thrombocytopenia 1 (X-linked); Wiskott-Aldrich syndrome (eczema-thrombocytopenia) protein; THC1; Wiskott-Aldrich syndrome protein; WASP antibody; Wiskott-Aldrich syndrome (eczema-thrombocytopenia) antibody; WAS antibody; THC antibody; IMD2 antibody; thrombocytopenia 1 (X-linked) antibody; Wiskott-Aldrich syndrome (eczema-thrombocytopenia) protein antibody; THC1 antibody; Wiskott-Aldrich syndrome protein antibody; Wiskott-Aldrich Syndrome; Wiskott-Aldrich Syndrome / WASP
 Product Gene Name   

anti-WAS antibody

[Similar Products]
 Product Synonym Gene Name    WASP [Similar Products]
 Antibody/Peptide Pairs    Wiskott-Aldrich Syndrome / WASP peptide (MBS426192) is used for blocking the activity of Wiskott-Aldrich Syndrome/WASP antibody (MBS420239)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    SPADKKRSGK KKI
 OMIM    300299
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-SPADKKRSGKKKI, from the internal region of the protein sequence according to NP_000368.1.
 Epitope    Internal region
 Note    No cross-reactivity expected with N WASP (WASL).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-WAS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-WAS antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-WAS antibody    Peptide ELISA: Antibody detection limit dilution 1: 128000.
Western Blot: Approx 60kDa band observed in Human lysates of Tcell line MOLT4 and monocytic cell line U937 (calculated MW of 52.9kDa according to NP_000368.1). Recommended concentration: 0. 03-0.1ug/ml.
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 Western Blot (WB) of anti-WAS antibody    Staining (0. 03ug/ml) of U937 lysate (RIPA buffer, 30ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
anti-WAS antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for WAS. It may not necessarily be applicable to this product.
 NCBI GI #    4507909
 NCBI GeneID    7454
 NCBI Accession #    NP_000368.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000377.2 [Other Products]
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 UniProt Secondary Accession #    Q9BU11; Q9UNJ9 [Other Products]
 UniProt Related Accession #    P42768 [Other Products]
 Molecular Weight    52,913 Da
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 NCBI Official Full Name    wiskott-Aldrich syndrome protein
 NCBI Official Synonym Full Names    Wiskott-Aldrich syndrome
 NCBI Official Symbol    WAS [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    wiskott-Aldrich syndrome protein
 UniProt Protein Name    Wiskott-Aldrich syndrome protein
 Protein Family    Wiskott-Aldrich syndrome protein
 UniProt Gene Name    WAS [Similar Products]
 UniProt Synonym Gene Names    IMD2; WASp [Similar Products]
 UniProt Entry Name    WASP_HUMAN
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 NCBI Summary for WAS    The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known. [provided by RefSeq, Jul 2008]
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 UniProt Comments for WAS    WASP: a member of the Wiskott-Aldrich syndrome (WAS) family of proteins. A cytoplasmic protein expressed exclusively in hematopoietic cells. Transduces signals from surface receptors to the actin cytoskeleton. Associates with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Mutated in Wiskott-Aldrich syndrome, a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: Xp11.4-p11.21

Cellular Component: actin cytoskeleton; cytosol; intercellular junction; vesicle membrane

Molecular Function: actin binding; GTPase regulator activity; identical protein binding; phospholipase binding; protein binding; protein kinase binding; SH3 domain binding

Biological Process: actin filament polymerization; actin filament-based movement; actin polymerization and/or depolymerization; blood coagulation; defense response; endosome transport; epidermis development; immune response; protein complex assembly; regulation of catalytic activity; regulation of T cell antigen processing and presentation; T cell activation; T cell receptor signaling pathway

Disease: Neutropenia, Severe Congenital, X-linked; Thrombocytopenia 1
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 Research Articles on WAS    1. Platelet actin nodule formation is dependent on WASp and the ARP2/3 complex.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-WAS antibody
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