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anti-XAF1 antibody :: Rabbit anti-Human XAF1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS241350
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

XAF1, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human XAF1

 Product Synonym Names    Anti-XAF1 Antibody IHC-plus; XAF1; BIRC4 binding protein; BIRC4-binding protein; BIRC4BP; HSXIAPAF1; XIAP-associated factor 1; XIAPAF1; XIAP associated factor 1; Human XAF1
 Product Gene Name   

anti-XAF1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    606717
 3D Structure    ModBase 3D Structure for Q6GPH4
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    synthetic peptide corresponding to 16 amino acids near the middle of human XAF-1
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.02% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human XAF1.
 Immunogen Type    Synthetic peptide
 Immunogen    XAF1 antibody was raised against synthetic peptide from human XAF1.
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 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
 Other Notes    Small volumes of anti-XAF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-XAF1 antibody

   XAF-1 binds to XIAP, an inhibitor of caspases-3, -7, and -9, and triggers its relocation from the cytosol to the nucleus. Overexpression of XAF-1 results in the neutralization of XIAP's ability to inhibit cell death. XAF-1 is normally expressed in all adult and fetal tissues but was found to be present in very low levels in a variety of cancer cell lines. In contrast, XIAP levels have been shown to be high in a majority of cell lines.
 Product Categories/Family for anti-XAF1 antibody    Family: Apoptosis
 Applications Tested/Suitable for anti-XAF1 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

 Application Notes for anti-XAF1 antibody    IHC-P (10 ug/ml), WB (1 - 2 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-XAF1 antibody    Anti-XAF1 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-XAF1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-XAF1 antibody    Immunofluorescence of XAF-1 in Human Spleen cells with XAF-1 antibody at 20 ug/ml.
anti-XAF1 antibody Immunofluorescence (IF) image
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 Western Blot (WB) of anti-XAF1 antibody    Western blot of XAF-1 in human spleen lysate with XAF-1 antibody (IN) at 1 (lane A), 2 (lane B), and 4 (lane C) ug/ml, respectively.
anti-XAF1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for XAF1. It may not necessarily be applicable to this product.
 NCBI GI #    40288191
 NCBI GeneID    54739
 NCBI Accession #    NP_059993.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_017523.3 [Other Products]
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 UniProt Primary Accession #    Q6GPH4 [Other Products]
 UniProt Secondary Accession #    Q6MZE8; Q8N557; Q99982; A2T931; A2T932; A8K2L1; A8K9Y3; D3DTM6 [Other Products]
 UniProt Related Accession #    Q6GPH4 [Other Products]
 Molecular Weight    34,543 Da
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 NCBI Official Full Name    XIAP-associated factor 1 isoform 1
 NCBI Official Synonym Full Names    XIAP associated factor 1
 NCBI Official Symbol    XAF1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    XIAP-associated factor 1; BIRC4 binding protein; BIRC4-binding protein
 UniProt Protein Name    XIAP-associated factor 1
 UniProt Synonym Protein Names   
BIRC4-binding protein
 Protein Family    XIAP-associated factor
 UniProt Gene Name    XAF1 [Similar Products]
 UniProt Synonym Gene Names    BIRC4BP; XIAPAF1 [Similar Products]
 UniProt Entry Name    XAF1_HUMAN
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 NCBI Summary for XAF1    This gene encodes a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during apoptosis. The proportion of IAPs and proteins which interfere with their activity, such as the encoded protein, affect the progress of the apoptosis signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
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 UniProt Comments for XAF1    BIRC4BP: Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti- caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha- induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Tumor suppressor

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: mitochondrion; cytosol; nucleus

Molecular Function: zinc ion binding

Biological Process: apoptosis; cytokine and chemokine mediated signaling pathway; negative regulation of protein complex assembly
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 Research Articles on XAF1    1. Transcriptionally active p73 induces translocation of XAF-1 during apoptosis caused by melphalan. XAF-1 directly interacts with Puma and promotes Bax translocation during melphalan-induced apoptosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-XAF1 antibodyPathways associated with anti-XAF1 antibody
 Reference Product  PubMed Publications
 MX1 antibody  >3 publications with XAF1 and MX1
 IFI6 antibody  >2 publications with XAF1 and IFI6
 IFIT1 antibody  >2 publications with XAF1 and IFIT1
 ISG15 antibody  >2 publications with XAF1 and ISG15
 OASL antibody  >1 publications with XAF1 and OASL
 OAS1 antibody  >1 publications with XAF1 and OAS1
 IFIT2 antibody  >1 publications with XAF1 and IFIT2
 IFIT3 antibody  >1 publications with XAF1 and IFIT3
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 Interferon Alpha/beta Signaling Pathway antibodies  Interferon Alpha/beta Signaling Pathway Diagram
Diseases associated with anti-XAF1 antibodyOrgans/Tissues associated with anti-XAF1 antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >29 publications with XAF1 and Carcinoma
 Colorectal Neoplasms Antibodies  >17 publications with XAF1 and Colorectal Neoplasms
 Colonic Neoplasms Antibodies  >15 publications with XAF1 and Colonic Neoplasms
 Stomach Neoplasms Antibodies  >14 publications with XAF1 and Stomach Neoplasms
 Adenocarcinoma Antibodies  >13 publications with XAF1 and Adenocarcinoma
 Necrosis Antibodies  >11 publications with XAF1 and Necrosis
 Carcinoma, Hepatocellular Antibodies  >9 publications with XAF1 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >6 publications with XAF1 and Liver Diseases
 Liver Neoplasms Antibodies  >6 publications with XAF1 and Liver Neoplasms
 Nervous System Diseases Antibodies  >6 publications with XAF1 and Nervous System Diseases
 Organ/Tissue Name  Pubmed Publications
 Stomach Antibodies  >14 publications with XAF1 and Stomach
 Blood Antibodies  >11 publications with XAF1 and Blood
 Liver Antibodies  >10 publications with XAF1 and Liver
 Vascular Antibodies  >7 publications with XAF1 and Vascular
 Lung Antibodies  >7 publications with XAF1 and Lung
 Prostate Antibodies  >6 publications with XAF1 and Prostate
 Kidney Antibodies  >5 publications with XAF1 and Kidney
 Bladder Antibodies  >5 publications with XAF1 and Bladder
 Placenta Antibodies  >4 publications with XAF1 and Placenta
 Brain Antibodies  >4 publications with XAF1 and Brain
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