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anti-XBP1 antibody :: Goat XBP1/TREB5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421063
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

XBP1/TREB5, Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-XBP1/TREB5 Antibody

 Product Synonym Names    XBP1; TREB5; X-box binding protein 1; XBP2; OTTHUMP00000028682; X-box-binding protein-1; XBP1 antibody; TREB5 antibody; X-box binding protein 1 antibody; XBP2 antibody; OTTHUMP00000028682 antibody; X-box-binding protein-1 antibody; XBP1 / TREB5
 Product Gene Name   

anti-XBP1 antibody

[Similar Products]
 Product Synonym Gene Name    TREB5 [Similar Products]
 Antibody/Peptide Pairs    XBP1 / TREB5 peptide (MBS425286) is used for blocking the activity of XBP1/TREB5 antibody (MBS421063)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    NHSWEDTFAN ELFPQ
 OMIM    194355
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-NHSWEDTFANELFPQ, from the internal region of the protein sequence according to NP_001073007.1.
 Epitope    Internal region
 Note    This antibody is expected to recognise isoform XBP1(S) (NP_001073007.1) only.
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-XBP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-XBP1 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-XBP1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 4000.
Western Blot: Approx 38kDa band observed in Nuclear lysates of cell line HeLa (calculated MW of 40.1kDa according to NP_001073007.1). Recommended concentration: 1-3ug/ml.
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 Western Blot (WB) of anti-XBP1 antibody    (1ug/ml) staining of nuclear HeLa lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-XBP1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for XBP1. It may not necessarily be applicable to this product.
 NCBI GI #    118640873
 NCBI GeneID    7494
 NCBI Accession #    NP_001073007.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001079539.1 [Other Products]
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 UniProt Secondary Accession #    Q8WYK6; Q969P1; Q96BD7 [Other Products]
 UniProt Related Accession #    P17861 [Other Products]
 Molecular Weight    40,148 Da
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 NCBI Official Full Name    X-box-binding protein 1 isoform XBP1(S)
 NCBI Official Synonym Full Names    X-box binding protein 1
 NCBI Official Symbol    XBP1 [Similar Products]
 NCBI Official Synonym Symbols   
XBP2; TREB5; XBP-1; TREB-5
[Similar Products]
 NCBI Protein Information    X-box-binding protein 1
 UniProt Protein Name    X-box-binding protein 1
 UniProt Synonym Protein Names   
Tax-responsive element-binding protein 5
 Protein Family    X-box-binding protein
 UniProt Gene Name    XBP1 [Similar Products]
 UniProt Synonym Gene Names    TREB-5 [Similar Products]
 UniProt Entry Name    XBP1_HUMAN
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 NCBI Summary for XBP1    This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]
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 UniProt Comments for XBP1    XBP1: a transcription factor essential for hepatocyte growth, the differentiation of plasma cells, immunoglobulin secretion, and the unfolded protein response (UPR). XBP1 mRNA is spliced by IRE1 during the UPR to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis. Only the spliced form of XBP1 can activate the UPR efficiently. Activates UPR target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'-GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter. Binds to the Tax-responsive element (TRE) of HTLV-I. Up-regulated by ATF6 via direct binding to the ERSE in response to endoplasmic reticulum stress. Genetic variations in XBP1 could be associated with susceptibility to major affective disorder type 7 (MAFD7). Major affective disorders represent a class of mental disorders characterized by a disturbance in mood as their predominant feature. Two human isoforms are produced by alternative splicing. Isoform 1 is also known as XBP-1U. Isoform 2, also known as XBP-1S, is produced by IRE1 in response to endoplasmic reticulum stress. IRE1 cleaves a 26-bp fragment causing a frameshift of the mRNA transcript.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 22q12.1|22q12

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; integral to membrane; nucleoplasm; nucleus

Molecular Function: chromatin DNA binding; DNA binding; estrogen receptor binding; histone deacetylase binding; protease binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; transcription factor activity; ubiquitin protein ligase binding

Biological Process: angiogenesis; autophagy; cell growth; cellular response to glucose starvation; cellular response to insulin stimulus; cellular response to nutrient; cholesterol homeostasis; endothelial cell proliferation; exocrine pancreas development; fatty acid biosynthetic process; fatty acid homeostasis; immune response; liver development; muscle development; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; neuron development; organelle organization and biogenesis; phosphoinositide 3-kinase cascade; positive regulation of autophagy; positive regulation of B cell differentiation; positive regulation of fat cell differentiation; positive regulation of histone methylation; positive regulation of immunoglobulin production; positive regulation of immunoglobulin secretion; positive regulation of MHC class II biosynthetic process; positive regulation of protein amino acid phosphorylation; positive regulation of T cell differentiation; positive regulation of TOR signaling pathway; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription of target genes involved in unfolded protein response; protein destabilization; protein transport; regulation of autophagy; regulation of protein stability; sterol homeostasis; transcription from RNA polymerase II promoter; ubiquitin-dependent protein catabolic process; unfolded protein response; vascular endothelial growth factor receptor signaling pathway

Disease: Major Affective Disorder 7
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 Research Articles on XBP1    1. the present study provides initial evidence that RITA upregulates the expression level of IRE1a by increasing the stability of IRE1alpha mRNA in irradiated mtp53-expressing cervical cancer cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-XBP1 antibodyPathways associated with anti-XBP1 antibody
 Reference Product  PubMed Publications
 DDIT3 antibody  >271 publications with XBP1 and DDIT3
 ATF6 antibody  >268 publications with XBP1 and ATF6
 ERN1 antibody  >151 publications with XBP1 and ERN1
 HSPA5 antibody  >61 publications with XBP1 and HSPA5
 BCL2 antibody  >28 publications with XBP1 and BCL2
 FOXA1 antibody  >6 publications with XBP1 and FOXA1
 ESR1 antibody  >4 publications with XBP1 and ESR1
 PIK3R1 antibody  >2 publications with XBP1 and PIK3R1
 NCOA3 antibody  >1 publications with XBP1 and NCOA3
 Products by Pathway  Pathway Diagram
 ATF6-alpha Activates Chaperone Genes Pathway antibodies  ATF6-alpha Activates Chaperone Genes Pathway Diagram
 ATF6-alpha Activates Chaperones Pathway antibodies  ATF6-alpha Activates Chaperones Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 IRE1alpha Activates Chaperones Pathway antibodies  IRE1alpha Activates Chaperones Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Non-alcoholic Fatty Liver Disease (NAFLD) Pathway antibodies  Non-alcoholic Fatty Liver Disease (NAFLD) Pathway Diagram
 Non-alcoholic Fatty Liver Disease (NAFLD) Pathway antibodies  Non-alcoholic Fatty Liver Disease (NAFLD) Pathway Diagram
Diseases associated with anti-XBP1 antibodyOrgans/Tissues associated with anti-XBP1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >81 publications with XBP1 and Inflammation
 Cardiovascular Diseases Antibodies  >73 publications with XBP1 and Cardiovascular Diseases
 Liver Diseases Antibodies  >67 publications with XBP1 and Liver Diseases
 Disease Models, Animal Antibodies  >65 publications with XBP1 and Disease Models, Animal
 Nervous System Diseases Antibodies  >62 publications with XBP1 and Nervous System Diseases
 Brain Diseases Antibodies  >47 publications with XBP1 and Brain Diseases
 Fatty Liver Antibodies  >38 publications with XBP1 and Fatty Liver
 Necrosis Antibodies  >37 publications with XBP1 and Necrosis
 Carcinoma, Hepatocellular Antibodies  >24 publications with XBP1 and Carcinoma, Hepatocellular
 Hepatitis Antibodies  >22 publications with XBP1 and Hepatitis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >138 publications with XBP1 and Blood
 Liver Antibodies  >116 publications with XBP1 and Liver
 Brain Antibodies  >93 publications with XBP1 and Brain
 Pancreas Antibodies  >48 publications with XBP1 and Pancreas
 Muscle Antibodies  >47 publications with XBP1 and Muscle
 Intestine Antibodies  >40 publications with XBP1 and Intestine
 Bone Antibodies  >39 publications with XBP1 and Bone
 Vascular Antibodies  >37 publications with XBP1 and Vascular
 Nerve Antibodies  >34 publications with XBP1 and Nerve
 Kidney Antibodies  >31 publications with XBP1 and Kidney
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