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anti-XBP1 antibody :: Rabbit anti-Human, Mouse XBP1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS240773
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

XBP1, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit Polyclonal to Human XBP1

 Product Synonym Names    Anti-XBP1 Antibody (N-Terminus) IHC-plus; XBP1; X-box binding protein 1; X-box-binding protein 1; XBP2; TREB5; XBP-1; Human XBP1
 Product Gene Name   

anti-XBP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 612371
 3D Structure    ModBase 3D Structure for P17861
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    18 amino acid peptide from near the amino terminus of human XBP-1
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.02% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human XBP1.
 Immunogen Type    Synthetic peptide
 Immunogen    XBP1 antibody was raised against synthetic peptide from human XBP1.
 Antigen Modification    N-Terminus
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 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
 Other Notes    Small volumes of anti-XBP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-XBP1 antibody

   XBP1 is a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. It is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator.
 Applications Tested/Suitable for anti-XBP1 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

 Application Notes for anti-XBP1 antibody    IHC-P (20 ug/ml), WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
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 Immunohistochemistry (IHC) of anti-XBP1 antibody    Anti-XBP1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
anti-XBP1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunocytochemistry (ICC) of anti-XBP1 antibody    Immunocytochemistry of XBP-1 in HepG2 cells with XBP-1 antibody at 10 ug/ml.
anti-XBP1 antibody Immunocytochemistry (ICC) (ICC) image
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 Western Blot (WB) of anti-XBP1 antibody    Western blot of XBP-1 in HepG2 cell lysate with XBP-1 antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml.
anti-XBP1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for XBP1. It may not necessarily be applicable to this product.
 NCBI GI #    14110395
 NCBI GeneID    7494
 NCBI Accession #    NP_005071.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_005080.3 [Other Products]
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 UniProt Primary Accession #    P17861 [Other Products]
 UniProt Secondary Accession #    Q8WYK6; Q969P1; Q96BD7 [Other Products]
 UniProt Related Accession #    P17861 [Other Products]
 Molecular Weight    40,148 Da
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 NCBI Official Full Name    X-box-binding protein 1 isoform XBP1(U)
 NCBI Official Synonym Full Names    X-box binding protein 1
 NCBI Official Symbol    XBP1 [Similar Products]
 NCBI Official Synonym Symbols   
XBP2; TREB5; XBP-1
[Similar Products]
 NCBI Protein Information    X-box-binding protein 1; tax-responsive element-binding protein 5
 UniProt Protein Name    X-box-binding protein 1
 UniProt Synonym Protein Names   
Tax-responsive element-binding protein 5
 Protein Family    X-box-binding protein
 UniProt Gene Name    XBP1 [Similar Products]
 UniProt Synonym Gene Names    TREB5; XBP2; XBP-1 [Similar Products]
 UniProt Entry Name    XBP1_HUMAN
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 NCBI Summary for XBP1    This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]
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 UniProt Comments for XBP1    XBP1: a transcription factor essential for hepatocyte growth, the differentiation of plasma cells, immunoglobulin secretion, and the unfolded protein response (UPR). XBP1 mRNA is spliced by IRE1 during the UPR to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis. Only the spliced form of XBP1 can activate the UPR efficiently. Activates UPR target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'-GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter. Binds to the Tax-responsive element (TRE) of HTLV-I. Up-regulated by ATF6 via direct binding to the ERSE in response to endoplasmic reticulum stress. Genetic variations in XBP1 could be associated with susceptibility to major affective disorder type 7 (MAFD7). Major affective disorders represent a class of mental disorders characterized by a disturbance in mood as their predominant feature. Two human isoforms are produced by alternative splicing. Isoform 1 is also known as XBP-1U. Isoform 2, also known as XBP-1S, is produced by IRE1 in response to endoplasmic reticulum stress. IRE1 cleaves a 26-bp fragment causing a frameshift of the mRNA transcript.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 22q12.1|22q12

Cellular Component: nucleoplasm; endoplasmic reticulum membrane; endoplasmic reticulum; cytoplasm; integral to membrane; integral to endoplasmic reticulum membrane; nucleus; cytosol

Molecular Function: protein binding; protein homodimerization activity; protease binding; DNA binding; chromatin DNA binding; protein heterodimerization activity; ubiquitin protein ligase binding; estrogen receptor binding; protein kinase binding; transcription factor activity

Biological Process: ubiquitin-dependent protein catabolic process; transcription from RNA polymerase II promoter; phosphoinositide 3-kinase cascade; muscle development; apoptosis; exocrine pancreas development; positive regulation of transcription of target genes involved in unfolded protein response; regulation of protein stability; negative regulation of transcription from RNA polymerase II promoter; cellular response to glucose starvation; protein transport; serotonin secretion, neurotransmission; positive regulation of MHC class II biosynthetic process; positive regulation of transcription factor import into nucleus; angiogenesis; cell growth; response to electrical stimulus; fatty acid biosynthetic process; positive regulation of TOR signaling pathway; positive regulation of autophagy; response to drug; positive regulation of histone methylation; protein destabilization; unfolded protein response; organelle organization and biogenesis; cellular response to nutrient; positive regulation of immunoglobulin secretion; liver development; cholesterol homeostasis; positive regulation of immunoglobulin production; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; cellular response to insulin stimulus; positive regulation of T cell differentiation; endothelial cell proliferation; fatty acid homeostasis; neuron development; positive regulation of B cell differentiation; autophagy; positive regulation of fat cell differentiation; immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; sterol homeostasis; vascular endothelial growth factor receptor signaling pathway; negative regulation of apoptosis

Disease: Major Affective Disorder 7
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 Research Articles on XBP1    1. XBP1u and HDAC3 exert a protective effect on disturbed flow-induced oxidative stress via up-regulation of mTORC2-dependent Akt1 phosphorylation and Nrf2-mediated HO-1 expression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-XBP1 antibodyPathways associated with anti-XBP1 antibody
 Reference Product  PubMed Publications
 ATF6 antibody  >165 publications with XBP1 and ATF6
 DDIT3 antibody  >147 publications with XBP1 and DDIT3
 JUN antibody  >100 publications with XBP1 and JUN
 ERN1 antibody  >73 publications with XBP1 and ERN1
 FOXA1 antibody  >6 publications with XBP1 and FOXA1
 ESR1 antibody  >4 publications with XBP1 and ESR1
 BMP4 antibody  >1 publications with XBP1 and BMP4
 Products by Pathway  Pathway Diagram
 ATF6-alpha Activates Chaperone Genes Pathway antibodies  ATF6-alpha Activates Chaperone Genes Pathway Diagram
 ATF6-alpha Activates Chaperones Pathway antibodies  ATF6-alpha Activates Chaperones Pathway Diagram
 FOXA1 Transcription Factor Network Pathway antibodies  FOXA1 Transcription Factor Network Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 IRE1alpha Activates Chaperones Pathway antibodies  IRE1alpha Activates Chaperones Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Non-alcoholic Fatty Liver Disease (NAFLD) Pathway antibodies  Non-alcoholic Fatty Liver Disease (NAFLD) Pathway Diagram
 Non-alcoholic Fatty Liver Disease (NAFLD) Pathway antibodies  Non-alcoholic Fatty Liver Disease (NAFLD) Pathway Diagram
Diseases associated with anti-XBP1 antibodyOrgans/Tissues associated with anti-XBP1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >63 publications with XBP1 and Inflammation
 Cardiovascular Diseases Antibodies  >56 publications with XBP1 and Cardiovascular Diseases
 Liver Diseases Antibodies  >47 publications with XBP1 and Liver Diseases
 Disease Models, Animal Antibodies  >46 publications with XBP1 and Disease Models, Animal
 Brain Diseases Antibodies  >41 publications with XBP1 and Brain Diseases
 Fatty Liver Antibodies  >29 publications with XBP1 and Fatty Liver
 Necrosis Antibodies  >25 publications with XBP1 and Necrosis
 Carcinoma, Hepatocellular Antibodies  >21 publications with XBP1 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >16 publications with XBP1 and Liver Neoplasms
 Atherosclerosis Antibodies  >14 publications with XBP1 and Atherosclerosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >114 publications with XBP1 and Blood
 Liver Antibodies  >85 publications with XBP1 and Liver
 Brain Antibodies  >75 publications with XBP1 and Brain
 Muscle Antibodies  >36 publications with XBP1 and Muscle
 Pancreas Antibodies  >36 publications with XBP1 and Pancreas
 Intestine Antibodies  >30 publications with XBP1 and Intestine
 Vascular Antibodies  >27 publications with XBP1 and Vascular
 Bone Antibodies  >27 publications with XBP1 and Bone
 Nerve Antibodies  >26 publications with XBP1 and Nerve
 Eye Antibodies  >21 publications with XBP1 and Eye
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