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anti-XIAP antibody :: Rabbit XIAP Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS127008
Western Blot (WB)
Unit / Price
0.05 mL  /  $305 +1 FREE 8GB USB
0.1 mL  /  $460 +1 FREE 8GB USB
0.2 mL  /  $685 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

XIAP, Polyclonal Antibody

 Also Known As   

XIAP Polyclonal Antibody

 Product Synonym Names    XIAP; API3; BIRC4; ILP1; MIHA; XLP2
 Product Gene Name   

anti-XIAP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 300635
 3D Structure    ModBase 3D Structure for P98170
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Route    Synthetic Peptide
 Immunogen    A synthetic peptide of human XIAP
 Calculated Molecular Weight    60kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-XIAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-XIAP antibody

   The inhibitor of apoptosis protein (IAP) family consists of an evolutionarily conserved group of apoptosis inhibitors containing a conserved 70 amino acid BIR (baculovirus inhibitor repeat) domain (1,2). Human members of this family include c-IAP1, c-IAP2, XIAP, survivin, livin, and NAIP. Overexpression of IAP family members, particularly survivin and livin, in cancer cell lines and primary tumors suggests an important role for these proteins in cancer progression (3-5). In general, the IAP proteins function through direct interactions to inhibit the activity of several caspases, including caspase-3, caspase-7, and caspase-9 (5,6). In addition, binding of IAP family members to the mitochondrial protein Smac blocks their interaction with caspase-9, thereby allowing the processing and activation of the caspase (2).
 Product Categories/Family for anti-XIAP antibody    Polyclonal
 Applications Tested/Suitable for anti-XIAP antibody   

Western Blot (WB)

 Application Notes for anti-XIAP antibody    WB: 1:500 - 1:1000
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 Western Blot (WB) of anti-XIAP antibody    Western blot analysis of HeLa cell and C6 cell lysate using XIAP Antibody.
anti-XIAP antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for XIAP. It may not necessarily be applicable to this product.
 NCBI GI #    12643387
 NCBI GeneID    331
 NCBI Accession #    P98170.2 [Other Products]
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 UniProt Primary Accession #    P98170 [Other Products]
 UniProt Secondary Accession #    Q9NQ14; D3DTF2 [Other Products]
 UniProt Related Accession #    P98170 [Other Products]
 Molecular Weight    497
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 NCBI Official Full Name    E3 ubiquitin-protein ligase XIAP
 NCBI Official Synonym Full Names    X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
 NCBI Official Symbol    XIAP [Similar Products]
 NCBI Official Synonym Symbols   
API3; ILP1; MIHA; XLP2; BIRC4; IAP-3; hIAP3; hIAP-3
[Similar Products]
 NCBI Protein Information    E3 ubiquitin-protein ligase XIAP; X-linked IAP; IAP-like protein; inhibitor of apoptosis protein 3; baculoviral IAP repeat-containing protein 4
 UniProt Protein Name    E3 ubiquitin-protein ligase XIAP
 UniProt Synonym Protein Names   
Baculoviral IAP repeat-containing protein 4; IAP-like protein; ILP; hILP; Inhibitor of apoptosis protein 3; IAP-3; hIAP-3; hIAP3; X-linked inhibitor of apoptosis protein; X-linked IAP
 Protein Family    XIAP-associated factor
 UniProt Gene Name    XIAP [Similar Products]
 UniProt Synonym Gene Names    API3; BIRC4; IAP3; ILP; hILP; IAP-3; hIAP-3; hIAP3; X-linked IAP [Similar Products]
 UniProt Entry Name    XIAP_HUMAN
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 NCBI Summary for XIAP    This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]
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 UniProt Comments for XIAP    XIAP: an apoptotic suppressor protein. Inhibist apoptosis through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2. Inhibits apoptosis induced by menadione, a potent inducer of free radicals, and ICE. Inhibits cell-death proteases, caspase-3, caspase-7, and perhaps caspase-9.

Protein type: EC 6.3.2.-; Apoptosis; Ubiquitin ligase; Ubiquitin conjugating system; Ligase

Chromosomal Location of Human Ortholog: Xq25

Cellular Component: nucleoplasm; spindle microtubule; cytoplasm; nucleus; cytosol

Molecular Function: protein binding; zinc ion binding; caspase inhibitor activity; ubiquitin-protein ligase activity; ligase activity

Biological Process: Wnt receptor signaling pathway; positive regulation of protein ubiquitination; apoptosis; regulation of inflammatory response; regulation of BMP signaling pathway; protein ubiquitination; negative regulation of caspase activity; response to DNA damage stimulus; copper ion homeostasis; regulation of cell proliferation; negative regulation of apoptosis; regulation of innate immune response

Disease: Lymphoproliferative Syndrome, X-linked, 1; Lymphoproliferative Syndrome, X-linked, 2
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 Research Articles on XIAP    1. Licochalcone-A sensitizes human esophageal carcinoma cells to TRAIL-mediated apoptosis by proteasomal degradation of XIAP.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to XIAP Polyclonal Antibody
 Catalog #  Product Name  Catalog #  Product Name
 MBS146071  Recombinant Human XIAP Associated Factor 1  MBS620050  Anti - XIAP (API3, Baculoviral IAP repeat-containing protein 4, BIRC4, hILP, HILP, IAP3, IAP-like pr...
 MBS9408144  XIAP Antibody  MBS7605773  XIAP Rabbit Polyclonal
 MBS8242375  Anti-XIAP (pS87) Antibody  MBS659818  XIAP (API3, Baculoviral IAP repeat-containing protein 4, BIRC4, hILP, HILP, IAP3, IAP-like protein, ...
 MBS1493432  Rabbit anti-human E3 ubiquitin-protein ligase XIAP polyclonal Antibody(XIAP)  MBS2543007  XIAP Polyclonal Antibody
 MBS9401421  XIAP (Phospho-Ser87) Antibody  MBS2024322  Inhibitor Of Apoptosis Protein, X-Linked (XIAP) ELISA Kit
Products associated with anti-XIAP antibodyPathways associated with anti-XIAP antibody
 Reference Product  PubMed Publications
 CASP3 antibody  >865 publications with XIAP and CASP3
 CASP9 antibody  >418 publications with XIAP and CASP9
 DIABLO antibody  >306 publications with XIAP and DIABLO
 BIRC5 antibody  >196 publications with XIAP and BIRC5
 CASP7 antibody  >80 publications with XIAP and CASP7
 HTRA2 antibody  >78 publications with XIAP and HTRA2
 TAB1 antibody  >11 publications with XIAP and TAB1
 RIPK2 antibody  >8 publications with XIAP and RIPK2
 UBC antibody  >3 publications with XIAP and UBC
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Factor-mediated Response Pathway antibodies  Apoptotic Factor-mediated Response Pathway Diagram
 BMP Receptor Signaling Pathway antibodies  BMP Receptor Signaling Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
Diseases associated with anti-XIAP antibodyOrgans/Tissues associated with anti-XIAP antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >444 publications with XIAP and Necrosis
 Leukemia Antibodies  >368 publications with XIAP and Leukemia
 Nervous System Diseases Antibodies  >155 publications with XIAP and Nervous System Diseases
 Breast Neoplasms Antibodies  >106 publications with XIAP and Breast Neoplasms
 Liver Diseases Antibodies  >105 publications with XIAP and Liver Diseases
 Brain Diseases Antibodies  >104 publications with XIAP and Brain Diseases
 Neoplasms, Experimental Antibodies  >102 publications with XIAP and Neoplasms, Experimental
 Inflammation Antibodies  >94 publications with XIAP and Inflammation
 Lung Neoplasms Antibodies  >92 publications with XIAP and Lung Neoplasms
 Liver Neoplasms Antibodies  >92 publications with XIAP and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >310 publications with XIAP and Blood
 Brain Antibodies  >167 publications with XIAP and Brain
 Liver Antibodies  >139 publications with XIAP and Liver
 Lung Antibodies  >133 publications with XIAP and Lung
 Prostate Antibodies  >114 publications with XIAP and Prostate
 Bone Antibodies  >89 publications with XIAP and Bone
 Vascular Antibodies  >79 publications with XIAP and Vascular
 Nerve Antibodies  >77 publications with XIAP and Nerve
 Muscle Antibodies  >72 publications with XIAP and Muscle
 Bone Marrow Antibodies  >55 publications with XIAP and Bone Marrow
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