AAF87574.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
xeroderma pigmentosum group C protein
NCBI Official Synonym Full Names
xeroderma pigmentosum, complementation group C
NCBI Protein Information
DNA repair protein complementing XP-C cells; p125; mutant xeroderma pigmentosum group C
UniProt Protein Name
DNA repair protein complementing XP-C cells
UniProt Synonym Protein Names
Xeroderma pigmentosum group C-complementing protein; p125
UniProt Synonym Gene Names
UniProt Entry Name
XPC_HUMAN
NCBI Summary for XPC
This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
UniProt Comments for XPC
XPC: a probable nuclear protein involved in DNA excision repair. May play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes. Defects in XPC are a cause of xeroderma pigmentosum complementation group C.
Protein type: DNA repair, damage
Chromosomal Location of Human Ortholog: 3p25.1
Cellular Component: nucleoplasm; cytoplasm; nucleolus; plasma membrane; nucleus
Molecular Function: protein binding; damaged DNA binding; bubble DNA binding; single-stranded DNA binding; loop DNA binding
Biological Process: response to drug; nucleotide-excision repair, DNA damage recognition; intra-S DNA damage checkpoint; nucleotide-excision repair; nucleotide-excision repair, DNA damage removal; DNA repair; response to UV-B
Disease: Xeroderma Pigmentosum, Complementation Group C
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Products associated with anti-XPC antibody
Pathways associated with anti-XPC antibody
Diseases associated with anti-XPC antibody
Organs/Tissues associated with anti-XPC antibody
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