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anti-XRCC4 antibody :: anti-Human XRCC4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9128276
Western Blot (WB)
Unit / Price
0.05 mL  /  $285 +1 FREE 8GB USB
0.2 mL  /  $555 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

XRCC4, Polyclonal Antibody

 Also Known As   

XRCC4 Polyclonal Antibody

 Product Gene Name   

anti-XRCC4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    194363
 3D Structure    ModBase 3D Structure for Q13426
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 Clonality    Polyclonal
 Isotype    IgG
 Species Reactivity    Human
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 Purity/Purification    Affinity Purification
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 Source    Rabbit
 Category    Primary Antibody
 Immunogen    A synthetic peptide of human XRCC4
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles
 Other Notes    Small volumes of anti-XRCC4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-XRCC4 antibody

   The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants.
 Applications Tested/Suitable for anti-XRCC4 antibody   

Western Blot (WB)

 Application Notes for anti-XRCC4 antibody    WB: 1:500 - 1:2000
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 Western Blot (WB) of anti-XRCC4 antibody    Western blot analysis of extracts of K-562 cell line, using XRCC4 antibody.
anti-XRCC4 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for XRCC4. It may not necessarily be applicable to this product.
 NCBI GI #    4507945
 NCBI GeneID    7518
 NCBI Accession #    NP_003392.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003401.3 [Other Products]
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 UniProt Primary Accession #    Q13426 [Other Products]
 UniProt Secondary Accession #    Q9BS72; Q9UP94; A8K3X4 [Other Products]
 UniProt Related Accession #    Q13426 [Other Products]
 Molecular Weight    38kDa
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 NCBI Official Full Name    DNA repair protein XRCC4 isoform 1
 NCBI Official Synonym Full Names    X-ray repair complementing defective repair in Chinese hamster cells 4
 NCBI Official Symbol    XRCC4 [Similar Products]
 NCBI Protein Information    DNA repair protein XRCC4
 UniProt Protein Name    DNA repair protein XRCC4
 UniProt Synonym Protein Names   
X-ray repair cross-complementing protein 4
 Protein Family    Xrcc4-like factor
 UniProt Gene Name    XRCC4 [Similar Products]
 UniProt Entry Name    XRCC4_HUMAN
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 NCBI Summary for XRCC4    The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants. [provided by RefSeq, Sep 2008]
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 UniProt Comments for XRCC4    XRCC4: Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. Homodimer and homotetramer in solution. The homodimer associates with LIG4, and the LIG4-XRCC4 complex associates in a DNA-dependent manner with the DNA-PK complex formed by the Ku p70/p86 dimer (XRCC6/XRCC5) and PRKDC. Seems to interact directly with PRKDC but not with the Ku p70/86 dimer. Interacts with XLF/Cernunnos. Interacts with APTX and APLF. Widely expressed. Belongs to the XRCC4 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA repair, damage

Chromosomal Location of Human Ortholog: 5q14.2

Cellular Component: nucleoplasm; DNA ligase IV complex; centrosome; condensed chromosome; DNA-dependent protein kinase complex; cell junction; cytosol; nucleus

Molecular Function: protein C-terminus binding; protein binding; DNA binding; ligase activity

Biological Process: pro-B cell differentiation; positive regulation of neurogenesis; central nervous system development; immunoglobulin V(D)J recombination; viral reproduction; in utero embryonic development; T cell differentiation in the thymus; isotype switching; DNA repair; double-strand break repair via nonhomologous end joining; positive regulation of fibroblast proliferation; double-strand break repair; response to gamma radiation; DNA ligation during DNA repair; negative regulation of neuron apoptosis; positive regulation of ligase activity; response to X-ray

Disease: Short Stature, Microcephaly, And Endocrine Dysfunction
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 Research Articles on XRCC4    1. The present results collectively indicated that Lys271, but not Lys210, of XRCC4 is required for the nuclear localization of XRCC4 and LIG4 and that the nuclear localizing ability is essential for DSB repair function of XRCC4.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-XRCC4 antibodyPathways associated with anti-XRCC4 antibody
 Reference Product  PubMed Publications
 XRCC5 antibody  >71 publications with XRCC4 and XRCC5
 PRKDC antibody  >64 publications with XRCC4 and PRKDC
 LIG4 antibody  >57 publications with XRCC4 and LIG4
 NHEJ1 antibody  >47 publications with XRCC4 and NHEJ1
 MRE11A antibody  >14 publications with XRCC4 and MRE11A
 XRCC6 antibody  >12 publications with XRCC4 and XRCC6
 APLF antibody  >10 publications with XRCC4 and APLF
 PNKP antibody  >5 publications with XRCC4 and PNKP
 APTX antibody  >3 publications with XRCC4 and APTX
 Products by Pathway  Pathway Diagram
 2-LTR Circle Formation Pathway antibodies  2-LTR Circle Formation Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Double-Strand Break Repair Pathway antibodies  Double-Strand Break Repair Pathway Diagram
 Early Phase Of HIV Life Cycle Pathway antibodies  Early Phase Of HIV Life Cycle Pathway Diagram
 HIV Infection Pathway antibodies  HIV Infection Pathway Diagram
 HIV Life Cycle Pathway antibodies  HIV Life Cycle Pathway Diagram
 Infectious Disease Pathway antibodies  Infectious Disease Pathway Diagram
 Integration Of Provirus Pathway antibodies  Integration Of Provirus Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
Diseases associated with anti-XRCC4 antibodyOrgans/Tissues associated with anti-XRCC4 antibody
 Disease Name  Pubmed Publications
 Chromosome Aberrations Antibodies  >42 publications with XRCC4 and Chromosome Aberrations
 Carcinoma Antibodies  >24 publications with XRCC4 and Carcinoma
 Breast Neoplasms Antibodies  >20 publications with XRCC4 and Breast Neoplasms
 Nervous System Diseases Antibodies  >13 publications with XRCC4 and Nervous System Diseases
 Lung Neoplasms Antibodies  >12 publications with XRCC4 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >9 publications with XRCC4 and Neoplasms, Experimental
 Adenocarcinoma Antibodies  >7 publications with XRCC4 and Adenocarcinoma
 Urinary Bladder Neoplasms Antibodies  >6 publications with XRCC4 and Urinary Bladder Neoplasms
 Carcinoma, Squamous Cell Antibodies  >5 publications with XRCC4 and Carcinoma, Squamous Cell
 Kidney Diseases Antibodies  >5 publications with XRCC4 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >58 publications with XRCC4 and Blood
 Brain Antibodies  >14 publications with XRCC4 and Brain
 Prostate Antibodies  >8 publications with XRCC4 and Prostate
 Kidney Antibodies  >8 publications with XRCC4 and Kidney
 Bone Marrow Antibodies  >8 publications with XRCC4 and Bone Marrow
 Skin Antibodies  >7 publications with XRCC4 and Skin
 Liver Antibodies  >7 publications with XRCC4 and Liver
 Embryonic Tissue Antibodies  >5 publications with XRCC4 and Embryonic Tissue
 Vascular Antibodies  >3 publications with XRCC4 and Vascular
 Lymph Node Antibodies  >3 publications with XRCC4 and Lymph Node
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