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anti-XRCC6 antibody :: Rabbit XRCC6 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2521024
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

XRCC6, Polyclonal Antibody

★Popular Item★
 Also Known As   

XRCC6 Polyclonal Antibody

 Product Synonym Names    ML8, KU70, TLAA, CTC75, CTCBF, G22P1
 Product Gene Name   

anti-XRCC6 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    152690
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    0.4mg/mL (lot specific)
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 Immunogen    Recombinant protein of human XRCC6
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-XRCC6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-XRCC6 antibody

   The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus.
 Product Categories/Family for anti-XRCC6 antibody    Cancer
 Applications Tested/Suitable for anti-XRCC6 antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-XRCC6 antibody    IHC: 1:10-1:50
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 Immunohistochemistry (IHC) of anti-XRCC6 antibody    Immunohistochemistry of paraffin-embedded Human colon cancer tissue using XRCC6 Polyclonal Antibody at dilution of 1:10
anti-XRCC6 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-XRCC6 antibody    Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using XRCC6 Polyclonal Antibody at dilution of 1:10
anti-XRCC6 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for XRCC6. It may not necessarily be applicable to this product.
 NCBI GI #    573014819
 NCBI GeneID    2547
 NCBI Accession #    NP_001275907.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001288978.1 [Other Products]
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 UniProt Secondary Accession #    Q6FG89; Q9UCQ2; Q9UCQ3; B1AHC8 [Other Products]
 UniProt Related Accession #    P12956 [Other Products]
 Molecular Weight    65,149 Da
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 NCBI Official Full Name    X-ray repair cross-complementing protein 6 isoform 3
 NCBI Official Synonym Full Names    X-ray repair complementing defective repair in Chinese hamster cells 6
 NCBI Official Symbol    XRCC6 [Similar Products]
 NCBI Official Synonym Symbols   
ML8; KU70; TLAA; CTC75; CTCBF; G22P1
[Similar Products]
 NCBI Protein Information    X-ray repair cross-complementing protein 6; 5'-dRP lyase Ku70; 5'-deoxyribose-5-phosphate lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; ATP-dependent DNA helicase II, 70 kDa subunit; CTC box binding factor 75 kDa subunit; CTC box-binding factor 75 kDa subunit; DNA repair protein XRCC6; Ku autoantigen p70 subunit; Ku autoantigen, 70kDa; lupus Ku autoantigen protein p70; thyroid autoantigen 70kD (Ku antigen); thyroid autoantigen 70kDa (Ku antigen); thyroid-lupus autoantigen p70
 UniProt Protein Name    X-ray repair cross-complementing protein 6
 UniProt Synonym Protein Names   
5'-deoxyribose-5-phosphate lyase Ku70; 5'-dRP lyase Ku70; 70 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 1; ATP-dependent DNA helicase II 70 kDa subunit; CTC box-binding factor 75 kDa subunit; CTC75; CTCBF; DNA repair protein XRCC6; Lupus Ku autoantigen protein p70; Ku70; Thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 6
 Protein Family    X-ray repair cross-complementing protein
 UniProt Gene Name    XRCC6 [Similar Products]
 UniProt Synonym Gene Names    G22P1; 5'-dRP lyase Ku70; CTC75; CTCBF; Ku70; TLAA [Similar Products]
 UniProt Entry Name    XRCC6_HUMAN
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 NCBI Summary for XRCC6    The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. [provided by RefSeq, Jul 2008]
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 UniProt Comments for XRCC6    Ku70: a mini-chromosome maintenance protein, essential for the initiation of eukaryotic genome replication. Allows DNA to undergo a single round of replication per cell cycle. Required for the entry in S phase and for cell division.

Protein type: Helicase; EC 3.6.4.-; RNA-binding; DNA repair, damage; Nuclear receptor co-regulator; DNA-binding; EC 4.2.99.-

Chromosomal Location of Human Ortholog: 22q13.2

Cellular Component: nucleoplasm; transcription factor complex; nuclear telomere cap complex; membrane; nucleolus; cytosol; nucleus

Molecular Function: ATP-dependent DNA helicase activity; protein C-terminus binding; protein binding; DNA binding; double-stranded DNA binding; damaged DNA binding; double-stranded telomeric DNA binding; 5'-deoxyribose-5-phosphate lyase activity; ATP binding

Biological Process: positive regulation of neurogenesis; V(D)J recombination; viral reproduction; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; DNA repair; DNA duplex unwinding; double-strand break repair via nonhomologous end joining; DNA ligation; double-strand break repair; positive regulation of interferon type I production; innate immune response; positive regulation of transcription from RNA polymerase II promoter; brain development; negative regulation of transcription, DNA-dependent; telomere maintenance
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 Research Articles on XRCC6    1. the VNTR polymorphism at the promoter region of XRCC5, but not XRCC6, may have a role in breast cancer risk or age at diagnosis of breast cancer
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-XRCC6 antibodyPathways associated with anti-XRCC6 antibody
 Reference Product  PubMed Publications
 XRCC5 antibody  >22 publications with XRCC6 and XRCC5
 XRCC4 antibody  >10 publications with XRCC6 and XRCC4
 LIG4 antibody  >6 publications with XRCC6 and LIG4
 PARP1 antibody  >5 publications with XRCC6 and PARP1
 PRKDC antibody  >5 publications with XRCC6 and PRKDC
 TP53 antibody  >1 publications with XRCC6 and TP53
 SIRT1 antibody  >1 publications with XRCC6 and SIRT1
 BAX antibody  >1 publications with XRCC6 and BAX
 WRN antibody  >1 publications with XRCC6 and WRN
 Products by Pathway  Pathway Diagram
 2-LTR Circle Formation Pathway antibodies  2-LTR Circle Formation Pathway Diagram
 BARD1 Signaling Events Pathway antibodies  BARD1 Signaling Events Pathway Diagram
 Coregulation Of Androgen Receptor Activity Pathway antibodies  Coregulation Of Androgen Receptor Activity Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 DNA-PK Complex Pathway antibodies  DNA-PK Complex Pathway Diagram
 DNA-PK Complex Pathway antibodies  DNA-PK Complex Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Double-Strand Break Repair Pathway antibodies  Double-Strand Break Repair Pathway Diagram
 Early Phase Of HIV Life Cycle Pathway antibodies  Early Phase Of HIV Life Cycle Pathway Diagram
Diseases associated with anti-XRCC6 antibodyOrgans/Tissues associated with anti-XRCC6 antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >13 publications with XRCC6 and Carcinoma
 Adenocarcinoma Antibodies  >9 publications with XRCC6 and Adenocarcinoma
 Breast Neoplasms Antibodies  >6 publications with XRCC6 and Breast Neoplasms
 Carcinoma, Hepatocellular Antibodies  >5 publications with XRCC6 and Carcinoma, Hepatocellular
 Chromosome Aberrations Antibodies  >4 publications with XRCC6 and Chromosome Aberrations
 Liver Diseases Antibodies  >4 publications with XRCC6 and Liver Diseases
 Lymphoma Antibodies  >4 publications with XRCC6 and Lymphoma
 Liver Neoplasms Antibodies  >4 publications with XRCC6 and Liver Neoplasms
 Leukemia Antibodies  >3 publications with XRCC6 and Leukemia
 Lung Neoplasms Antibodies  >3 publications with XRCC6 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11 publications with XRCC6 and Blood
 Liver Antibodies  >5 publications with XRCC6 and Liver
 Lung Antibodies  >4 publications with XRCC6 and Lung
 Kidney Antibodies  >3 publications with XRCC6 and Kidney
 Brain Antibodies  >3 publications with XRCC6 and Brain
 Bone Antibodies  >2 publications with XRCC6 and Bone
 Bladder Antibodies  >2 publications with XRCC6 and Bladder
 Ovary Antibodies  >2 publications with XRCC6 and Ovary
 Bone Marrow Antibodies  >2 publications with XRCC6 and Bone Marrow
 Prostate Antibodies  >2 publications with XRCC6 and Prostate
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