NP_001177906.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
12,738 Da
NCBI Official Full Name
YY1-associated factor 2 isoform 3
NCBI Official Synonym Full Names
YY1 associated factor 2
NCBI Protein Information
YY1-associated factor 2
UniProt Protein Name
YY1-associated factor 2
UniProt Entry Name
YAF2_HUMAN
NCBI Summary for YAF2
This gene encodes a zinc finger containing protein that functions in the regulation of transcription. This protein was identified as an interacting partner of transcriptional repressor protein Yy1, and also interacts with other transcriptional regulators, including Myc and Polycomb. This protein can promote proteolysis of Yy1. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Feb 2016]
UniProt Comments for YAF2
YAF2: Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 12q12
Cellular Component: cytoplasm; nucleoplasm; nucleus
Molecular Function: protein binding; transcription coactivator activity; transcription corepressor activity; zinc ion binding
Biological Process: negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent
Research Articles on YAF2
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Diseases associated with anti-YAF2 antibody
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