NP_001177906.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
12,738 Da
NCBI Official Full Name
YY1-associated factor 2 isoform 3
NCBI Official Synonym Full Names
YY1 associated factor 2
NCBI Protein Information
YY1-associated factor 2
UniProt Protein Name
YY1-associated factor 2
UniProt Entry Name
YAF2_HUMAN
NCBI Summary for YAF2
The protein encoded by this gene interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. This gene product itself contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]
UniProt Comments for YAF2
YAF2: Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 12q12
Cellular Component: nucleoplasm; cytoplasm; nucleus
Molecular Function: protein binding; zinc ion binding; transcription coactivator activity; transcription corepressor activity
Biological Process: transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent
Research Articles on YAF2
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Products associated with anti-YAF2 antibody
Diseases associated with anti-YAF2 antibody
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