BC037777
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
12,738 Da
NCBI Official Full Name
Homo sapiens YY1 associated factor 2, mRNA
NCBI Official Synonym Full Names
YY1 associated factor 2
NCBI Protein Information
YY1-associated factor 2
UniProt Protein Name
YY1-associated factor 2
NCBI Summary for YAF2
This gene encodes a zinc finger containing protein that functions in the regulation of transcription. This protein was identified as an interacting partner of transcriptional repressor protein Yy1, and also interacts with other transcriptional regulators, including Myc and Polycomb. This protein can promote proteolysis of Yy1. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Feb 2016]
UniProt Comments for YAF2
Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling.
Product References and Citations for anti-YAF2 antibody
(1) Trynka, G., Zhernakova, A., Romanos, J., et al. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signaling. Gut 58 (8), 1078-1083 (2009).
Research Articles on YAF2
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Disclaimer
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Products associated with anti-YAF2 antibody
Diseases associated with anti-YAF2 antibody
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