NP_001123617.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
yorkie homolog isoform 1
NCBI Official Synonym Full Names
Yes-associated protein 1
NCBI Protein Information
transcriptional coactivator YAP1
UniProt Protein Name
Transcriptional coactivator YAP1
UniProt Synonym Protein Names
Protein yorkie homolog; Yes-associated protein YAP65 homolog
UniProt Synonym Gene Names
UniProt Entry Name
YAP1_HUMAN
NCBI Summary for YAP1
This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013]
UniProt Comments for YAP1
YAP1: an adaptor protein that binds to HER4 and the SH3 domain of the Yes tyrosine kinase. Associates with multiple transcription factors in the nucleus, and appears to be a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus. Contains a WW domain that is found in various structural, regulatory and signaling molecules.
Protein type: Oncoprotein; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 11q13
Cellular Component: nucleoplasm; transcription factor complex; membrane; cytoplasm; cell junction; cytosol; nucleus
Molecular Function: protein binding; transcription coactivator activity; chromatin binding; transcription corepressor activity
Biological Process: paraxial mesoderm development; transcription initiation from RNA polymerase II promoter; somatic stem cell maintenance; lateral mesoderm development; cell morphogenesis; negative regulation of epithelial cell differentiation; notochord development; positive regulation of organ growth; keratinocyte differentiation; cell proliferation; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; gene expression; vasculogenesis; response to DNA damage stimulus
Disease: Coloboma, Ocular, With Or Without Hearing Impairment, Cleft Lip/palate, And/or Mental Retardation
Product References and Citations for anti-YAP1 antibody
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) : Wang, Y., et al. Cancer Sci. 101(5):1279-1285(2010) Liu, A.M., et al. Biochem. Biophys. Res. Commun. 394(3):623-627(2010) Watt, K.I., et al. Biochem. Biophys. Res. Commun. 393(4):619-624(2010) Zhao, B., et al. Genes Dev. 24(1):72-85(2010)
Research Articles on YAP1
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Products associated with anti-YAP1 antibody
Pathways associated with anti-YAP1 antibody
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Diseases associated with anti-YAP1 antibody
Organs/Tissues associated with anti-YAP1 antibody
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