Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow YAP rightarrow Polyclonal YAP  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Cell adhesion molecule 3 (Cadm3) ELISA Kit
 • NADPH oxidase 4 (NOX4) ELISA Kit
 • IgG Immunoglobulin
 • E Coli O157:H7 Antibody
 • MAP2 Antibody
 • MYBPC3 Antibody
 • CD119 Antibody
 • Axis Inhibition Protein (AXIN) ELISA Kit
 • HIV-1 p24 Recombinant Protein
 • Ultrasensitive Growth Hormone (UGH) ELISA Kit
 • VASP Antibody
 • Mouse IgE Isotype Control
 • Adapter protein CIKS (TRAF3IP2) ELISA Kit
 • UGT8 Peptide
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-YAP antibody :: Rabbit YAP Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9413065
Western Blot (WB)
Unit / Price
0.05 mL  /  $200 +1 FREE 8GB USB
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

YAP, Polyclonal Antibody

 Also Known As   

YAP (Phospho-Ser127) Antibody

 Product Synonym Names    YAP65; YAP1
 Product Gene Name   

anti-YAP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    120433
 3D Structure    ModBase 3D Structure for P46937
Section Bar
 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
Section Bar
 Specificity    The antibody detects endogenous level of YAP only when phosphorylated at serine 127.
 Purity/Purification    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1.0 mg/ml (lot specific)
Section Bar
 Immunogen Type    Peptide-KLH
 Immunogen Description    Peptide sequence around phosphorylation site of serine127(A-H-S(p)-S-P) derived from Human YAP.
 Modification    Phospho-Ser127
 Target Name    YAP
Section Bar
 Preparation and Storage    Store at -20 degree C/1 year
 Other Notes    Small volumes of anti-YAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-YAP antibody

   Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Plays a key role to control cell proliferation in response to cell contact.Sorrentino G, et al. (2014) Nat Cell Biol 16, 357-66 Yang S, et al. (2014) Cell Signal 26, 343-51 Sun W, et al. (2014) Mol Biol Rep 41, 947-56
 Product Categories/Family for anti-YAP antibody    Phospho-specific Ab
 Applications Tested/Suitable for anti-YAP antibody   

Western Blot (WB)

 Application Notes for anti-YAP antibody    Western blotting: 1:500~1:1000
Section Bar
 Western Blot (WB) of anti-YAP antibody    Western blot analysis of extracts from COS7 tissue using YAP (Phospho-Ser127) antibody.The lane on the right is treated with the antigen-specific peptide.
anti-YAP antibody Western Blot (WB) (WB) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for YAP. It may not necessarily be applicable to this product.
 NCBI GI #    194306653
 NCBI GeneID    10413
 NCBI Accession #    NP_001123617.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001130145.2 [Other Products]
Section Bar
 UniProt Primary Accession #    P46937 [Other Products]
 UniProt Secondary Accession #    Q7Z574; B4DTY1; B7ZA01; E3WEB5; E3WEB6; E9PRV2; F5H202; K0KQ18; K0KYZ8; K0L195; K0L1G3 [Other Products]
 UniProt Related Accession #    P46937 [Other Products]
 Molecular Weight    54,942 Da
Table BarTOPTable Bar
 NCBI Official Full Name    yorkie homolog isoform 1
 NCBI Official Synonym Full Names    Yes-associated protein 1
 NCBI Official Symbol    YAP1 [Similar Products]
 NCBI Official Synonym Symbols   
YAP; YKI; COB1; YAP2; YAP65
[Similar Products]
 NCBI Protein Information    transcriptional coactivator YAP1
 UniProt Protein Name    Transcriptional coactivator YAP1
 UniProt Synonym Protein Names   
Protein yorkie homolog; Yes-associated protein YAP65 homolog
 Protein Family    Yapsin
 UniProt Gene Name    YAP1 [Similar Products]
 UniProt Synonym Gene Names    YAP65; Yes-associated protein 1 [Similar Products]
 UniProt Entry Name    YAP1_HUMAN
Section Bar
 NCBI Summary for YAP    This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013]
Section Bar
 UniProt Comments for YAP    Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:18158288). The presence of TEAD transcription factors are required for it to stimulate gene expression, cell growth, anchorage-independent growth, and epithelial mesenchymal transition (EMT) induction (PubMed:18579750).
Table BarTOPTable Bar
 Research Articles on YAP    1. YAP mRNA might be one of the targets of miR-506.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-YAP antibodyPathways associated with anti-YAP antibody
 Reference Product  PubMed Publications
 LATS1 antibody  >44 publications with YAP and LATS1
 LATS2 antibody  >23 publications with YAP and LATS2
 TEAD1 antibody  >21 publications with YAP and TEAD1
 TEAD4 antibody  >11 publications with YAP and TEAD4
 AMOT antibody  >10 publications with YAP and AMOT
 TEAD2 antibody  >8 publications with YAP and TEAD2
 TEAD3 antibody  >3 publications with YAP and TEAD3
 SMAD7 antibody  >1 publications with YAP and SMAD7
 TP73 antibody  >1 publications with YAP and TP73
 Products by Pathway  Pathway Diagram
 ErbB4 Signaling Events Pathway antibodies  ErbB4 Signaling Events Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
Diseases associated with anti-YAP antibodyOrgans/Tissues associated with anti-YAP antibody
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >54 publications with YAP and Adenocarcinoma
 Cell Transformation, Neoplastic Antibodies  >39 publications with YAP and Cell Transformation, Neoplastic
 Liver Neoplasms Antibodies  >36 publications with YAP and Liver Neoplasms
 Liver Diseases Antibodies  >33 publications with YAP and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >30 publications with YAP and Carcinoma, Hepatocellular
 Breast Neoplasms Antibodies  >25 publications with YAP and Breast Neoplasms
 Lung Neoplasms Antibodies  >23 publications with YAP and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >17 publications with YAP and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >16 publications with YAP and Disease Models, Animal
 Nervous System Diseases Antibodies  >16 publications with YAP and Nervous System Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >45 publications with YAP and Liver
 Lung Antibodies  >34 publications with YAP and Lung
 Muscle Antibodies  >31 publications with YAP and Muscle
 Brain Antibodies  >21 publications with YAP and Brain
 Kidney Antibodies  >17 publications with YAP and Kidney
 Ovary Antibodies  >15 publications with YAP and Ovary
 Skin Antibodies  >15 publications with YAP and Skin
 Connective Tissue Antibodies  >15 publications with YAP and Connective Tissue
 Embryonic Tissue Antibodies  >13 publications with YAP and Embryonic Tissue
 Vascular Antibodies  >12 publications with YAP and Vascular
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions