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anti-YES1 antibody :: Rabbit anti-Human YES1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7049400
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

YES1, Polyclonal Antibody

★Popular Item★
 Also Known As   

YES1 Antibody

 Product Synonym Names    Tyrosine-protein kinase Yes; Proto-oncogene c-Yes; p61-Yes; YES1; YES
 Product Gene Name   

anti-YES1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    M15990 mRNA
 3D Structure    ModBase 3D Structure for P07947
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Tyrosine-protein kinase Yes protein (1-155AA)
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, PH 7.4
 Conjugation    Non-conjugated
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-30676 / sc-28883 / sc-14
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-YES1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-YES1 antibody

   Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.
 Applications Tested/Suitable for anti-YES1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-YES1 antibody    WB: 1: 1000-1: 5000
IHC: 1: 20-1: 200
IF: 1: 50-1: 200
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 Western Blot (WB) of anti-YES1 antibody    Western Blot
Positive WB detected in:Hela whole cell lysate,Jurkat whole cell lysate
All lanes: YES1 antibody at 3.2ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 61 kDa
Observed band size: 61,70 kDa

anti-YES1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-YES1 antibody    Immunohistochemistry of paraffin-embedded human testis tissue using MBS7049400 at dilution of 1:100
anti-YES1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-YES1 antibody    Immunohistochemistry of paraffin-embedded human gastric cancer using MBS7049400 at dilution of 1:100
anti-YES1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-YES1 antibody    Immunofluorescent analysis of Hela cells using MBS7049400 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-YES1 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for YES1. It may not necessarily be applicable to this product.
 NCBI GI #    4885661
 NCBI GeneID    7525
 NCBI Accession #    NP_005424.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005433.3 [Other Products]
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 UniProt Primary Accession #    P07947 [Other Products]
 UniProt Secondary Accession #    A6NLB3; D3DUH1 [Other Products]
 UniProt Related Accession #    P07947 [Other Products]
 Molecular Weight    60,801 Da
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 NCBI Official Full Name    tyrosine-protein kinase Yes
 NCBI Official Synonym Full Names    YES proto-oncogene 1, Src family tyrosine kinase
 NCBI Official Symbol    YES1 [Similar Products]
 NCBI Official Synonym Symbols   
Yes; c-yes; HsT441; P61-YES
[Similar Products]
 NCBI Protein Information    tyrosine-protein kinase Yes
 UniProt Protein Name    Tyrosine-protein kinase Yes
 UniProt Synonym Protein Names   
Proto-oncogene c-Yes; p61-Yes
 Protein Family    Tyrosine-protein kinase
 UniProt Gene Name    YES1 [Similar Products]
 UniProt Synonym Gene Names    YES [Similar Products]
 UniProt Entry Name    YES_HUMAN
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 NCBI Summary for YES1    This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]
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 UniProt Comments for YES1    Yes: a proto-oncogenic cytosolic tyrosine kinase of the Src family. Expressed at high levels in adult neurons, spermatozoa, platelets, and epithelial cells.

Protein type: EC 2.7.10.2; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Src family; TK group

Chromosomal Location of Human Ortholog: 18p11.31-p11.21

Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membrane; focal adhesion; Golgi apparatus; plasma membrane

Molecular Function: enzyme binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein-tyrosine kinase activity; receptor binding

Biological Process: cell differentiation; ephrin receptor signaling pathway; innate immune response; leukocyte migration; protein modification process; regulation of cell proliferation; regulation of vascular permeability; T cell costimulation; transmembrane receptor protein tyrosine kinase signaling pathway
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 Research Articles on YES1    1. Up-regulation of miR-210 inhibits hepatocellular carcinoma cell proliferation. Yes1 is a target of miR-210 and affects cell proliferation in HCC.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-YES1 antibodyDiseases associated with anti-YES1 antibody
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CD28 Co-stimulation Pathway antibodies  CD28 Co-stimulation Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 CTLA4 Inhibitory Signaling Pathway antibodies  CTLA4 Inhibitory Signaling Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >7 publications with YES1 and Neoplasm Metastasis
 Carcinoma, Squamous Cell Antibodies  >7 publications with YES1 and Carcinoma, Squamous Cell
 Nervous System Diseases Antibodies  >6 publications with YES1 and Nervous System Diseases
 Liver Neoplasms Antibodies  >6 publications with YES1 and Liver Neoplasms
 Cell Transformation, Neoplastic Antibodies  >6 publications with YES1 and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >6 publications with YES1 and Neoplasms, Experimental
 Lung Diseases Antibodies  >4 publications with YES1 and Lung Diseases
 Carcinoma, Hepatocellular Antibodies  >4 publications with YES1 and Carcinoma, Hepatocellular
 Ovarian Neoplasms Antibodies  >4 publications with YES1 and Ovarian Neoplasms
 Inflammation Antibodies  >4 publications with YES1 and Inflammation
Organs/Tissues associated with anti-YES1 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >15 publications with YES1 and Brain
 Liver Antibodies  >12 publications with YES1 and Liver
 Vascular Antibodies  >9 publications with YES1 and Vascular
 Lung Antibodies  >8 publications with YES1 and Lung
 Kidney Antibodies  >7 publications with YES1 and Kidney
 Pancreas Antibodies  >6 publications with YES1 and Pancreas
 Muscle Antibodies  >5 publications with YES1 and Muscle
 Skin Antibodies  >5 publications with YES1 and Skin
 Testis Antibodies  >4 publications with YES1 and Testis
 Intestine Antibodies  >3 publications with YES1 and Intestine
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