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anti-YTHDF2 antibody :: Rabbit YTHD2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9209250
Western Blot (WB)
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

YTHD2 (YTHDF2), Polyclonal Antibody

★Popular Item★
 Also Known As   

YTHD2 Antibody (C-term)

 Product Synonym Names    YTH domain-containing family protein 2; CLL-associated antigen KW-14; High-glucose-regulated protein 8; Renal carcinoma antigen NY-REN-2; YTHDF2; HGRG8
 Product Gene Name   

anti-YTHDF2 antibody

[Similar Products]
 Antibody/Peptide Pairs    YTHD2 peptide (MBS9221661) is used for blocking the activity of YTHD2 antibody (MBS9209250)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    551-579
 OMIM    610640
 3D Structure    ModBase 3D Structure for Q9Y5A9
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human (Predicted Reactivity: Bovine, Monkey, Mouse)
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 Specificity    This YTHD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 551-579 amino acids from the C-terminal region of human YTHD2.
 Purity/Purification    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
 Concentration    Vial Concentration: 0.5 (lot specific)
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 Antigen Type    Synthetic Peptide
 Antigen Source    HUMAN
 Other Accession    Q91YT7, Q4R5D9, Q0VCZ3, NP_001166299.1, NP_001166599.1
 Function    Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization of to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation.
 Cellular Location    Cytoplasm, P-body
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-YTHDF2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-YTHDF2 antibody

   YTHDF2 is a member of the YTH (YT521-B homology)
superfamily containing YTH domain. The YTH domain is typical for
the eukaryotes and is particularly abundant in plants. The YTH
domain is usually located in the middle of the protein sequence and
may function in binding to RNA. In addition to a YTH domain, this
protein has a proline rich region which may be involved in signal
transduction. An Alu-rich domain has been identified in one of the
introns of this gene, which is thought to be associated with human
longevity. In addition, reciprocal translocations between this gene
and the Runx1 (AML1) gene on chromosme 21 has been observed in
patients with acute myeloid leukemia. This gene was initially
mapped to chromosome 14, which was later turned out to be a
pseudogene.
 Product Categories/Family for anti-YTHDF2 antibody    Cell Biology
 Applications Tested/Suitable for anti-YTHDF2 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-YTHDF2 antibody    WB~~1:1000
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 Western Blot (WB) of anti-YTHDF2 antibody    YTHD2 Antibody (C-term) western blot analysis in U251 cell line lysates (35ug/lane).This demonstrates the YTHD2 antibody detected the YTHD2 protein (arrow).
anti-YTHDF2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for YTHDF2. It may not necessarily be applicable to this product.
 NCBI GI #    290543591
 NCBI GeneID    51441
 NCBI Accession #    NP_001166299.1 [Other Products]
 NCBI Related Accession #    NP_001166599.1; NP_057342.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001172828.1 [Other Products]
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 UniProt Primary Accession #    Q9Y5A9 [Other Products]
 UniProt Secondary Accession #    Q5VSZ9; Q8TDH0; Q9BUJ5; A6NKG4; A8K966; B4E1G7; D3DPM8 [Other Products]
 UniProt Related Accession #    Q9Y5A9 [Other Products]
 Molecular Weight    62334
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 NCBI Official Full Name    YTH domain-containing family protein 2 isoform 2
 NCBI Official Synonym Full Names    YTH N(6)-methyladenosine RNA binding protein 2
 NCBI Official Symbol    YTHDF2 [Similar Products]
 NCBI Official Synonym Symbols   
CAHL; HGRG8; NY-REN-2
[Similar Products]
 NCBI Protein Information    YTH domain-containing family protein 2
 UniProt Protein Name    YTH domain-containing family protein 2
 UniProt Synonym Protein Names   
CLL-associated antigen KW-14; High-glucose-regulated protein 8; Renal carcinoma antigen NY-REN-2
 Protein Family    YTH domain-containing family protein
 UniProt Gene Name    YTHDF2 [Similar Products]
 UniProt Synonym Gene Names    HGRG8 [Similar Products]
 UniProt Entry Name    YTHD2_HUMAN
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 NCBI Summary for YTHDF2    This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012]
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 UniProt Comments for YTHDF2    YTHDF2: high glucose-regulated protein 8. Two alternatively spliced isoforms have been described.

Protein type: RNA processing; RNA-binding

Chromosomal Location of Human Ortholog: 1p35

Biological Process: regulation of mRNA stability; humoral immune response

Disease: Longevity 1
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Product References and Citations for anti-YTHDF2 antibody

   Nguyen, T.T., et al. Genes Chromosomes Cancer 45(10):918-932(2006)
Cardelli, M., et al. J. Gerontol. A Biol. Sci. Med. Sci. 61(6):547-556(2006)
Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)
Stoilov, P., et al. Trends Biochem. Sci. 27(10):495-497(2002)
Scanlan, M.J., et al. Int. J. Cancer 83(4):456-464(1999)
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 Research Articles on YTHDF2    1. m(6)A is selectively recognized by the human YTH domain family 2 (YTHDF2) 'reader' protein to regulate mRNA degradation
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-YTHDF2 antibodyDiseases associated with anti-YTHDF2 antibody
 Reference Product  PubMed Publications
 SH3D19 antibody  >1 publications with YTHDF2 and SH3D19
 ZNF687 antibody  >1 publications with YTHDF2 and ZNF687
 Disease Name  Pubmed Publications
 Fetal Death Antibodies  >1 publications with YTHDF2 and Fetal Death
 Adenocarcinoma Antibodies  >1 publications with YTHDF2 and Adenocarcinoma
 Liver Diseases Antibodies  >1 publications with YTHDF2 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with YTHDF2 and Carcinoma, Hepatocellular
 Necrosis Antibodies  >1 publications with YTHDF2 and Necrosis
 Liver Neoplasms Antibodies  >1 publications with YTHDF2 and Liver Neoplasms
Organs/Tissues associated with anti-YTHDF2 antibody
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >1 publications with YTHDF2 and Nerve
 Blood Antibodies  >1 publications with YTHDF2 and Blood
 Liver Antibodies  >1 publications with YTHDF2 and Liver
 Thyroid Antibodies  >1 publications with YTHDF2 and Thyroid
 Placenta Antibodies  >1 publications with YTHDF2 and Placenta
 Testis Antibodies  >1 publications with YTHDF2 and Testis
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