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anti-AKAP9 antibody :: Rabbit Yotiao Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS616848 anti-AKAP9 antibody
Unit / Price
0.1 mg  /  $640 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Yotiao (AKAP9), Polyclonal Antibody

 Also Known As   

Yotiao (AKAP9, PRKA9, CG-NAP)

 Product Synonym Names    Anti -Yotiao (AKAP9, PRKA9, CG-NAP)
 Product Gene Name   

anti-AKAP9 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 7; NC_000007.13 (91570189..91739987). Location: 7q21-q22
 3D Structure    ModBase 3D Structure for Q5GIA7
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Recognizes human Yotiao protein. Species Crossreactivity: mouse and rat.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide, before the addition of glycerol to 40%.
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 Immunogen    Synthetic peptide derived from the C-terminal region of the human Yotiao protein.
 Positive Control    AsPC-1 cell lysates, rat and fetal mouse brain tissue homogenates.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-AKAP9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-AKAP9 antibody

   Yotiao is a novel cytoskeletal protein specifically concentrated in the neuromuscular junction and neuronal synapes that interacts with specific splice variants of NMDA Receptor Subunit NR1 in a C1 exon cassette-dependent manner (1). Yotiao has also been shown to physically attach the type I protein phosphatase (PP1) and the adenosine 3',5'-mono-phosphate (cAMP)- dependent protein kinase (PKA) holoenzyme to NMDA receptors to regulate channel activity (2). NMDA receptors are involved with many important functions and dysfunctions of the nervous system, including synapse formation, synaptic plasticity, and excitotoxicity. Yotiao research may lead to a clearer understanding of these neural processes by explaining how NMDA receptors are targeted to particular synapses, how this localization is regulated during development and synaptic activity, and how NMDA receptor activity is transduced into intracellular signals responsible for particular neuronal responses (1). Human tissue distribution studies with yotiao mRNA revealed that yotiao is abundantly present in skeletal muscle and pancreas, with lower expression in heart, placenta, and brain. Yotiao mRNA was undetectable in lung, liver, and kidney (1).
 Product Categories/Family for anti-AKAP9 antibody    Antibodies; Abs to Neuroscience
 Applications Tested/Suitable for anti-AKAP9 antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-AKAP9 antibody    Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 0.1-1.0ug/ml
Western Blot: 1-3ug/ml; Fetal mouse brain~230kD
AsPC-1 lysates and rat brain homogenates, multiple bands at other molecular weights have also been observed.
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NCBI/Uniprot data below describe general gene information for AKAP9. It may not necessarily be applicable to this product.
 NCBI GI #    2623068
 NCBI GeneID    10142
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 UniProt Primary Accession #    Q5GIA7 [Other Products]
 UniProt Related Accession #    Q5GIA7; Q5IBP5; Q6PJH3; Q8IW64; Q96KG3; Q99996; Q9UFL2 [Other Products]
 Molecular Weight    118,199 Da [Similar Products]
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 NCBI Official Full Name    yotiao
 NCBI Official Synonym Full Names    A kinase (PRKA) anchor protein (yotiao) 9
 NCBI Official Symbol    AKAP9 [Similar Products]
 NCBI Official Synonym Symbols   
PRKA9; AKAP-9; CG-NAP; YOTIAO; AKAP350; AKAP450; HYPERION; KIAA0803; MU-RMS-40.16A
[Similar Products]
 NCBI Protein Information    A-kinase anchor protein 9; protein yotiao; protein hyperion; OTTHUMP00000161771; AKAP 120-like protein; AKAP9-BRAF fusion protein; kinase N-associated protein; A-kinase anchor protein 350 kDa; A-kinase anchor protein 450 kDa; protein kinase A anchoring protein 9; centrosome- and Golgi-localized PKN-associated protein
 UniProt Protein Name    Antigen MU-RMS-40.16A
 Protein Family    A-kinase anchor protein
 UniProt Entry Name    Q5GIA7_HUMAN
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 NCBI Summary for AKAP9    The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternate splicing of this gene results in at least two isoforms that localize to the centrosome and the Golgi apparatus, and interact with numerous signaling proteins from multiple signal transduction pathways. These signaling proteins include type II protein kinase A, serine/threonine kinase protein kinase N, protein phosphatase 1, protein phosphatase 2a, protein kinase C-epsilon and phosphodiesterase 4D3. [provided by RefSeq]
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 UniProt Comments for AKAP9    AKAP9: Binds to type II regulatory subunits of protein kinase A. Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. May be required to maintain the integrity of the Golgi apparatus. Isoform 4 is associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations. Defects in AKAP9 are the cause of long QT syndrome type 11 (LQT11). Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 7q21-q22

Cellular Component: Golgi apparatus; centrosome; pericentriolar material; voltage-gated potassium channel complex; cytoskeleton; intracellular membrane-bound organelle; cytosol

Molecular Function: protein binding; potassium channel regulator activity; protein complex scaffold; receptor binding

Biological Process: synaptic transmission; transport; organelle organization and biogenesis; spermatogenesis; mitotic cell cycle; signal transduction; G2/M transition of mitotic cell cycle; positive regulation of peptidyl-serine phosphorylation; Sertoli cell development

Disease: Long Qt Syndrome 11
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 Research Articles on AKAP9    1. We describe a pathway that integrates Epac-mediated signals with AKAP9-dependent microtubule dynamics to coordinate integrins at lateral borders
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-AKAP9 antibodyPathways associated with anti-AKAP9 antibody
 Reference Product  PubMed Publications
 KCNQ1 antibody  >8 publications with AKAP9 and KCNQ1
 TUBGCP3 antibody  >1 publications with AKAP9 and TUBGCP3
 TSNAX antibody  >1 publications with AKAP9 and TSNAX
 TACC3 antibody  >1 publications with AKAP9 and TACC3
 PRKAR2A antibody  >1 publications with AKAP9 and PRKAR2A
 PPP2R1B antibody  >1 publications with AKAP9 and PPP2R1B
 CLIC1 antibody  >1 publications with AKAP9 and CLIC1
 Products by Pathway  Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 CREB Phosphorylation Through The Activation Of CaMKII Pathway antibodies  CREB Phosphorylation Through The Activation Of CaMKII Pathway Diagram
 CREB Phosphorylation Through The Activation Of Ras Pathway antibodies  CREB Phosphorylation Through The Activation Of Ras Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Centrosome Maturation Pathway antibodies  Centrosome Maturation Pathway Diagram
 G Protein Signaling Pathways antibodies  G Protein Signaling Pathways Diagram
 G2/M Transition Pathway antibodies  G2/M Transition Pathway Diagram
 Loss Of Nlp From Mitotic Centrosomes Pathway antibodies  Loss Of Nlp From Mitotic Centrosomes Pathway Diagram
 Loss Of Proteins Required For Interphase Microtubule Organization From The Centrosome Pathway antibodies  Loss Of Proteins Required For Interphase Microtubule Organization From The Centrosome Pathway Diagram
 Mitotic G2-G2/M Phases Pathway antibodies  Mitotic G2-G2/M Phases Pathway Diagram
Diseases associated with anti-AKAP9 antibodyOrgans/Tissues associated with anti-AKAP9 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >15 publications with AKAP9 and Neoplasms
 Long QT Syndrome Antibodies  >9 publications with AKAP9 and Long QT Syndrome
 Cardiovascular Diseases Antibodies  >8 publications with AKAP9 and Cardiovascular Diseases
 Heart Defects, Congenital Antibodies  >7 publications with AKAP9 and Heart Defects, Congenital
 Thyroid Neoplasms Antibodies  >7 publications with AKAP9 and Thyroid Neoplasms
 Carcinoma, Papillary Antibodies  >6 publications with AKAP9 and Carcinoma, Papillary
 Death, Sudden, Cardiac Antibodies  >5 publications with AKAP9 and Death, Sudden, Cardiac
 Chromosome Aberrations Antibodies  >4 publications with AKAP9 and Chromosome Aberrations
 Lung Diseases Antibodies  >2 publications with AKAP9 and Lung Diseases
 Colorectal Neoplasms Antibodies  >2 publications with AKAP9 and Colorectal Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >12 publications with AKAP9 and Heart
 Brain Antibodies  >11 publications with AKAP9 and Brain
 Muscle Antibodies  >9 publications with AKAP9 and Muscle
 Thyroid Antibodies  >7 publications with AKAP9 and Thyroid
 Blood Antibodies  >5 publications with AKAP9 and Blood
 Lung Antibodies  >4 publications with AKAP9 and Lung
 Lymph Node Antibodies  >2 publications with AKAP9 and Lymph Node
 Kidney Antibodies  >2 publications with AKAP9 and Kidney
 Nerve Antibodies  >2 publications with AKAP9 and Nerve
 Lymph Antibodies  >2 publications with AKAP9 and Lymph
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