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anti-ZBP1 antibody :: Rabbit anti-Human Z-DNA Binding Protein 1 (ZBP1) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2003183 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $105 +1 FREE 8GB USB
0.02 mg  /  $125 +1 FREE 8GB USB
0.05 mg  /  $170 +1 FREE 8GB USB
0.1 mg  /  $220 +1 FREE 8GB USB
0.2 mg  /  $320 +1 FREE 8GB USB
1 mg  /  $760 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Z-DNA Binding Protein 1 (ZBP1), Polyclonal Antibody

 Also Known As   

Polyclonal Antibody to Z-DNA Binding Protein 1 (ZBP1)

 Product Gene Name   

anti-ZBP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG SEF- R EGHLEQRILQ VLTEAGSPVK LAQLVKECQA PKRELNQVLY RMKKELKVSL TSPATWCLGG TDPEGEGPAE LALSSPAERP QQHAATIPET PGPQFSQQRE EDIYRFLKDN GPQRALVIAQ ALGMRTAKDV NRDLYRMKSR HLLDMDEQSK AWTIYRP
 OMIM    AJ300575 mRNA
 3D Structure    ModBase 3D Structure for Q9H171
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody is a rabbit polyclonal antibody raised against ZBP1. It has been selected for its ability to recognize ZBP1 in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
 Concentration    200ug/ml (lot specific)
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 Immunogen    Recombinant ZBP1 (Arg10~Pro167) expressed in E.coli.
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2056456
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-ZBP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ZBP1 antibody   

Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)

 Application Notes for anti-ZBP1 antibody    Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
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 Western Blot (WB) of anti-ZBP1 antibody    (Western Blot; Sample: Human Jurkat cell lysate;;Primary Ab: 2ug/ml Rabbit Anti-Human ZBP1 Antibody;Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody;)
anti-ZBP1 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-ZBP1 antibody    (Figure. Western Blot; Sample: Recombinant protein.)
anti-ZBP1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ZBP1 antibody    (DAB staining on IHC-P; Samples: Human Colorectal cancer Tissue)
anti-ZBP1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ZBP1 antibody    (Used in DAB staining on formalin fixed paraffin- embedded kidney tissue)
anti-ZBP1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ZBP1. It may not necessarily be applicable to this product.
 NCBI GI #    238550208
 NCBI GeneID    81030
 NCBI Accession #    NP_001153889.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001160417.1 [Other Products]
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 UniProt Primary Accession #    Q9H171 [Other Products]
 UniProt Secondary Accession #    Q5JY39; Q9BYW4; A2A2F7; B3KVA1; F5GYT1 [Other Products]
 UniProt Related Accession #    Q9H171 [Other Products]
 Molecular Weight    38,220 Da
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 NCBI Official Full Name    Z-DNA-binding protein 1 isoform b
 NCBI Official Synonym Full Names    Z-DNA binding protein 1
 NCBI Official Symbol    ZBP1 [Similar Products]
 NCBI Official Synonym Symbols   
DAI; DLM1; DLM-1; C20orf183
[Similar Products]
 NCBI Protein Information    Z-DNA-binding protein 1
 UniProt Protein Name    Z-DNA-binding protein 1
 UniProt Synonym Protein Names   
Tumor stroma and activated macrophage protein DLM-1
 Protein Family    Z-DNA-binding protein
 UniProt Gene Name    ZBP1 [Similar Products]
 UniProt Synonym Gene Names    C20orf183; DLM1 [Similar Products]
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 NCBI Summary for ZBP1    This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
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 UniProt Comments for ZBP1    ZBP1: Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 20q13.31

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: DNA binding; double-stranded RNA adenosine deaminase activity; left-handed Z-DNA binding; protein binding; RNA binding

Biological Process: innate immune response; positive regulation of interferon type I production; regulation of type I interferon production
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 Research Articles on ZBP1    1. Our results show that HSV2 is detected by a plethora of PRRs including DAI protein which trigger cytokine secretion to protect the host.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ZBP1 antibodyPathways associated with anti-ZBP1 antibody
 Reference Product  PubMed Publications
 IRF3 antibody  >15 publications with ZBP1 and IRF3
 TBK1 antibody  >7 publications with ZBP1 and TBK1
 RIPK3 antibody  >5 publications with ZBP1 and RIPK3
 TLR3 antibody  >4 publications with ZBP1 and TLR3
 IRF7 antibody  >4 publications with ZBP1 and IRF7
 RIPK1 antibody  >1 publications with ZBP1 and RIPK1
 Products by Pathway  Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 IRF3 Mediated Activation Of Type 1 IFN Pathway antibodies  IRF3 Mediated Activation Of Type 1 IFN Pathway Diagram
 IRF3-mediated Induction Of Type I IFN Pathway antibodies  IRF3-mediated Induction Of Type I IFN Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 RIP-mediated NFkB Activation Via ZBP1 Pathway antibodies  RIP-mediated NFkB Activation Via ZBP1 Pathway Diagram
 Regulation Of Innate Immune Responses To Cytosolic DNA Pathway antibodies  Regulation Of Innate Immune Responses To Cytosolic DNA Pathway Diagram
 STING Mediated Induction Of Host Immune Responses Pathway antibodies  STING Mediated Induction Of Host Immune Responses Pathway Diagram
Diseases associated with anti-ZBP1 antibodyOrgans/Tissues associated with anti-ZBP1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >12 publications with ZBP1 and Inflammation
 Carcinoma Antibodies  >6 publications with ZBP1 and Carcinoma
 Necrosis Antibodies  >6 publications with ZBP1 and Necrosis
 Neoplasms, Experimental Antibodies  >5 publications with ZBP1 and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >4 publications with ZBP1 and Breast Neoplasms
 Adenocarcinoma Antibodies  >3 publications with ZBP1 and Adenocarcinoma
 Kidney Diseases Antibodies  >3 publications with ZBP1 and Kidney Diseases
 Carcinoma, Hepatocellular Antibodies  >3 publications with ZBP1 and Carcinoma, Hepatocellular
 Heart Diseases Antibodies  >3 publications with ZBP1 and Heart Diseases
 Disease Models, Animal Antibodies  >3 publications with ZBP1 and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >10 publications with ZBP1 and Blood
 Liver Antibodies  >5 publications with ZBP1 and Liver
 Lymph Node Antibodies  >3 publications with ZBP1 and Lymph Node
 Muscle Antibodies  >2 publications with ZBP1 and Muscle
 Connective Tissue Antibodies  >1 publications with ZBP1 and Connective Tissue
 Spleen Antibodies  >1 publications with ZBP1 and Spleen
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