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anti-ZAK antibody :: Rabbit anti-Human, Mouse ZAK Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9126982
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ZAK, Polyclonal Antibody

 Also Known As   

ZAK

 Product Gene Name   

anti-ZAK antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    609479
 3D Structure    ModBase 3D Structure for Q9NYL2
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Species    Human
 Immunogen    Recombinant Protein
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 Other Notes    Small volumes of anti-ZAK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-ZAK antibody    Polyclonal
 Applications Tested/Suitable for anti-ZAK antibody   

Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-ZAK antibody    Western blot analysis of extracts of various cell lines, using ZAK antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 90s.
anti-ZAK antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ZAK antibody    Immunohistochemistry of paraffin-embedded human colon carcinoma using ZAK antibody at dilution of 1:100 (40x lens).
anti-ZAK antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ZAK antibody    Immunohistochemistry of paraffin-embedded human esophageal cancer using ZAK antibody at dilution of 1:100 (40x lens).
anti-ZAK antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-ZAK antibody    Immunofluorescence analysis of A549 cells using ZAK antibody. Blue: DAPI for nuclear staining.
anti-ZAK antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for ZAK. It may not necessarily be applicable to this product.
 NCBI GI #    313104215
 NCBI GeneID    51776
 NCBI Accession #    Q9NYL2.3 [Other Products]
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 UniProt Primary Accession #    Q9NYL2 [Other Products]
 UniProt Secondary Accession #    Q53SX1; Q580W8; Q59GY5; Q86YW8; Q9HCC4; Q9HCC5; Q9HDD2; Q9NYE9; B3KPG2 [Other Products]
 UniProt Related Accession #    Q9NYL2 [Other Products]
 Molecular Weight    800
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 NCBI Official Full Name    Mitogen-activated protein kinase kinase kinase MLT
 NCBI Official Symbol    ZAK [Similar Products]
 NCBI Official Synonym Symbols   
pk; AZK; MLT; MRK; MLK7; MLTK; mlklak
[Similar Products]
 NCBI Protein Information    mitogen-activated protein kinase kinase kinase MLT; HCCS-4; mixed lineage kinase 7; mixed lineage kinase-related kinase MRK-beta; human cervical cancer suppressor gene 4 protein; MLK-like mitogen-activated protein triple kinase; mixed lineage kinase with a leucine zipper and a sterile alpha motif
 UniProt Protein Name    Mitogen-activated protein kinase kinase kinase MLT
 UniProt Synonym Protein Names   
Human cervical cancer suppressor gene 4 protein; HCCS-4; Leucine zipper- and sterile alpha motif-containing kinase; MLK-like mitogen-activated protein triple kinase; Mixed lineage kinase-related kinase; MLK-related kinase; MRK; Sterile alpha motif- and leucine zipper-containing kinase AZK
 Protein Family    Mitogen-activated protein kinase kinase kinase
 UniProt Gene Name    ZAK [Similar Products]
 UniProt Synonym Gene Names    MLTK; HCCS-4; MLK-related kinase; MRK [Similar Products]
 UniProt Entry Name    MLTK_HUMAN
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 NCBI Summary for ZAK    This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ZAK    ZAK: a mixed-lineage kinase containing a leucine-zipper (LZ) and a sterile-alpha motif (SAM). It is reported to activate the JNK/SAPK and NF-kappaB pathways.

Protein type: Kinase, protein; Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.25; TKL group; MLK family; MLK subfamily

Chromosomal Location of Human Ortholog: 2q24.2

Cellular Component: cytoplasm; nucleus

Molecular Function: protein serine/threonine kinase activity; protein binding; MAP kinase kinase kinase activity; magnesium ion binding; ATP binding

Biological Process: cell death; activation of MAPKK activity; positive regulation of apoptosis; cytoskeleton organization and biogenesis; protein amino acid phosphorylation; activation of JNK activity; cell proliferation; response to radiation; DNA damage checkpoint; response to stress; cell differentiation; cell cycle arrest; cell cycle checkpoint
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 Research Articles on ZAK    1. we report that sorafenib suppresses UV-induced apoptosis specifically by inhibiting c-jun-NH(2)-kinase (JNK) activation through the off-target inhibition of leucine zipper and sterile alpha motif-containing kinase (ZAK)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ZAK antibodyDiseases associated with anti-ZAK antibody
 Products by Pathway  Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Signaling Mediated By P38-gamma And P38-delta Pathway antibodies  Signaling Mediated By P38-gamma And P38-delta Pathway Diagram
 Tight Junction Pathway antibodies  Tight Junction Pathway Diagram
 Tight Junction Pathway antibodies  Tight Junction Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >249 publications with ZAK and Cardiovascular Diseases
 Heart Diseases Antibodies  >164 publications with ZAK and Heart Diseases
 Nervous System Diseases Antibodies  >141 publications with ZAK and Nervous System Diseases
 Inflammation Antibodies  >87 publications with ZAK and Inflammation
 Hypertrophy Antibodies  >67 publications with ZAK and Hypertrophy
 Liver Diseases Antibodies  >61 publications with ZAK and Liver Diseases
 Lung Diseases Antibodies  >49 publications with ZAK and Lung Diseases
 Eye Diseases Antibodies  >42 publications with ZAK and Eye Diseases
 Atherosclerosis Antibodies  >40 publications with ZAK and Atherosclerosis
 Kidney Diseases Antibodies  >39 publications with ZAK and Kidney Diseases
Organs/Tissues associated with anti-ZAK antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >611 publications with ZAK and Blood
 Heart Antibodies  >226 publications with ZAK and Heart
 Muscle Antibodies  >192 publications with ZAK and Muscle
 Bone Antibodies  >146 publications with ZAK and Bone
 Brain Antibodies  >111 publications with ZAK and Brain
 Liver Antibodies  >102 publications with ZAK and Liver
 Vascular Antibodies  >71 publications with ZAK and Vascular
 Bone Marrow Antibodies  >65 publications with ZAK and Bone Marrow
 Eye Antibodies  >63 publications with ZAK and Eye
 Connective Tissue Antibodies  >62 publications with ZAK and Connective Tissue
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