P43404
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
ZAP-70
NCBI Official Synonym Full Names
zeta-chain (TCR) associated protein kinase
NCBI Official Synonym Symbols
Srk; TZK; mur; 70kDa; mrtle; ZAP-70; AI327364 [Similar Products]
NCBI Protein Information
tyrosine-protein kinase ZAP-70; syk-related tyrosine kinase; 70 kDa zeta-associated protein
UniProt Protein Name
Tyrosine-protein kinase ZAP-70
UniProt Synonym Protein Names
70 kDa zeta-associated protein; Syk-related tyrosine kinase
UniProt Synonym Gene Names
UniProt Entry Name
ZAP70_MOUSE
NCBI Summary for Zap70
This gene encodes a member of the protein tyrosine kinase family. The encoded protein is essential for development of T lymphocytes and thymocytes, and functions in the initial step of T lymphocyte receptor-mediated signal transduction. A mutation in this gene causes chronic autoimmune arthritis, similar to rheumatoid arthritis in humans. Mice lacking this gene are deficient in alpha-beta T lymphocytes in the thymus. In humans, mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T lymphocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
UniProt Comments for Zap70
ZAP70: a tyrosine kinase of the Syk family. Associates with the T-cell antigen receptor zeta-chain after TCR stimulation. Phosphorylated by Src-family kinases following antigen receptor activation. Plays a role in lymphocyte activation.
Protein type: Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Kinase, protein; EC 2.7.10.2; TK group; Syk family
Cellular Component: T cell receptor complex; extrinsic to internal side of plasma membrane; membrane; cytoplasm; plasma membrane; immunological synapse; intracellular; intercellular junction; cytosol; lipid raft
Molecular Function: transferase activity; protein binding; phosphotyrosine binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; non-membrane spanning protein tyrosine kinase activity; kinase activity; ATP binding; protein kinase activity; receptor binding
Biological Process: thymic T cell selection; cell migration; peptidyl-tyrosine phosphorylation; immune system process; protein amino acid autophosphorylation; positive regulation of calcium-mediated signaling; T cell receptor signaling pathway; protein amino acid phosphorylation; negative thymic T cell selection; positive regulation of T cell differentiation; innate immune response; positive regulation of alpha-beta T cell proliferation; immune response; beta selection; phosphorylation; positive regulation of alpha-beta T cell differentiation; transmembrane receptor protein tyrosine kinase signaling pathway; positive thymic T cell selection
Research Articles on Zap70
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Pathways associated with anti-Zap70 antibody
Diseases associated with anti-Zap70 antibody
Organs/Tissues associated with anti-Zap70 antibody
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