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anti-ZBP1 antibody :: Rabbit ZBP1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS150830
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ZBP1, Polyclonal Antibody

★Popular Item★
 Also Known As   

ZBP1 Antibody

 Product Synonym Names    ZBP1; DAI; DLM1; DLM-1; C20orf183; Z-DNA-binding protein 1; Tumor stroma and activated macrophage protein DLM-1; Z-DNA binding protein 1
 Product Gene Name   

anti-ZBP1 antibody

[Similar Products]
 Antibody/Peptide Pairs    ZBP1 peptide (MBS153012) is used for blocking the activity of ZBP1 antibody (MBS150830)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    606750
 3D Structure    ModBase 3D Structure for Q9H171
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    ZBP1 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    ZBP1 antibody was raised against a 18 amino acid synthetic peptide from near the carboxy terminus of human ZBP1.
 Buffer    ZBP1 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    ZBP1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-ZBP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ZBP1 antibody

   ZBP1 Antibody: Z-DNA binding protein 1 (ZBP1) belongs to a family of proteins that contain the Zalpha domain which binds specifically to left-handed Z-DNA and Z-RNA. ZBP1 was initially identified as a novel gene that was up-regulated in activated macrophages in mice bearing ascites tumors, suggesting that is may play a role in processes such as host response in neoplasia. More recent reports indicate that the cytosolic ZBP1 has can act like the toll-like receptor TLR9 by detecting cytosolic double-stranded (ds) DNA and trigger induction of type I interferon and other innate immune responses. It is thought that the binding of ZBP1 to dsDNA enhances its association with innate immune response proteins such as the IRF3 transcription factor and the serine/threonine kinase TBK1 (also known as NAK). Multiple isoforms of ZBP1 are known to exist.
 Applications Tested/Suitable for anti-ZBP1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-ZBP1 antibody    ZBP1 antibody can be used for the detection of ZBP1 by Western blot at 0.5 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-ZBP1 antibody    Western blot analysis of ZBP1 in mouse small intestine tissue lysate with ZBP1 antibody at (A) 0.5, (B) 1 and (C) 2 μg/mL.
anti-ZBP1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ZBP1 antibody    Immunohistochemistry of ZBP1 in human small intestine tissue with ZBP1 antibody at 2.5 μg/mL.
anti-ZBP1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-ZBP1 antibody    Immunofluorescence of ZBP1 in Human Small Intestine tissue with ZBP1 antibody at 20 μgg/mL.
anti-ZBP1 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for ZBP1. It may not necessarily be applicable to this product.
 NCBI GI #    119595916
 NCBI GeneID    81030
 NCBI Accession #    EAW75510 [Other Products]
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 UniProt Primary Accession #    Q9H171 [Other Products]
 UniProt Secondary Accession #    Q5JY39; Q9BYW4; A2A2F7; B3KVA1; F5GYT1 [Other Products]
 UniProt Related Accession #    Q9H171 [Other Products]
 Molecular Weight    38,220 Da
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 NCBI Official Full Name    Z-DNA binding protein 1, isoform CRA_b
 NCBI Official Synonym Full Names    Z-DNA binding protein 1
 NCBI Official Symbol    ZBP1 [Similar Products]
 NCBI Official Synonym Symbols   
DAI; DLM1; DLM-1; C20orf183
[Similar Products]
 NCBI Protein Information    Z-DNA-binding protein 1; DNA-dependent activator of IRFs; DNA-dependent activator of IFN-regulatory factors; tumor stroma and activated macrophage protein DLM-1; DNA-dependent activator of interferon regulatory factors
 UniProt Protein Name    Z-DNA-binding protein 1
 UniProt Synonym Protein Names   
Tumor stroma and activated macrophage protein DLM-1
 Protein Family    Z-DNA-binding protein
 UniProt Gene Name    ZBP1 [Similar Products]
 UniProt Synonym Gene Names    C20orf183; DLM1 [Similar Products]
 UniProt Entry Name    ZBP1_HUMAN
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 NCBI Summary for ZBP1    This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
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 UniProt Comments for ZBP1    ZBP1: Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; DNA-binding

Chromosomal Location of Human Ortholog: 20q13.31

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: double-stranded RNA adenosine deaminase activity; protein binding; DNA binding; left-handed Z-DNA binding; RNA binding

Biological Process: metabolic process; positive regulation of interferon type I production; innate immune response
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 Research Articles on ZBP1    1. Our results show that HSV2 is detected by a plethora of PRRs including DAI protein which trigger cytokine secretion to protect the host.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ZBP1 antibodyPathways associated with anti-ZBP1 antibody
 Reference Product  PubMed Publications
 IRF3 antibody  >15 publications with ZBP1 and IRF3
 TBK1 antibody  >7 publications with ZBP1 and TBK1
 RIPK3 antibody  >5 publications with ZBP1 and RIPK3
 IRF7 antibody  >4 publications with ZBP1 and IRF7
 TLR3 antibody  >3 publications with ZBP1 and TLR3
 RIPK1 antibody  >1 publications with ZBP1 and RIPK1
 Products by Pathway  Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 IRF3 Mediated Activation Of Type 1 IFN Pathway antibodies  IRF3 Mediated Activation Of Type 1 IFN Pathway Diagram
 IRF3-mediated Induction Of Type I IFN Pathway antibodies  IRF3-mediated Induction Of Type I IFN Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 RIP-mediated NFkB Activation Via ZBP1 Pathway antibodies  RIP-mediated NFkB Activation Via ZBP1 Pathway Diagram
 Regulation Of Innate Immune Responses To Cytosolic DNA Pathway antibodies  Regulation Of Innate Immune Responses To Cytosolic DNA Pathway Diagram
 STING Mediated Induction Of Host Immune Responses Pathway antibodies  STING Mediated Induction Of Host Immune Responses Pathway Diagram
Diseases associated with anti-ZBP1 antibodyOrgans/Tissues associated with anti-ZBP1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >12 publications with ZBP1 and Inflammation
 Carcinoma Antibodies  >6 publications with ZBP1 and Carcinoma
 Necrosis Antibodies  >6 publications with ZBP1 and Necrosis
 Neoplasms, Experimental Antibodies  >5 publications with ZBP1 and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >4 publications with ZBP1 and Breast Neoplasms
 Adenocarcinoma Antibodies  >3 publications with ZBP1 and Adenocarcinoma
 Kidney Diseases Antibodies  >3 publications with ZBP1 and Kidney Diseases
 Carcinoma, Hepatocellular Antibodies  >3 publications with ZBP1 and Carcinoma, Hepatocellular
 Heart Diseases Antibodies  >3 publications with ZBP1 and Heart Diseases
 Disease Models, Animal Antibodies  >3 publications with ZBP1 and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >10 publications with ZBP1 and Blood
 Liver Antibodies  >5 publications with ZBP1 and Liver
 Lymph Node Antibodies  >3 publications with ZBP1 and Lymph Node
 Muscle Antibodies  >2 publications with ZBP1 and Muscle
 Connective Tissue Antibodies  >1 publications with ZBP1 and Connective Tissue
 Spleen Antibodies  >1 publications with ZBP1 and Spleen
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