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anti-ZFYVE21 antibody :: Rabbit ZF21 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS151011
Unit / Price
0.02 mg  /  $140 +1 FREE 8GB USB
0.1 mg  /  $355 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ZF21 (ZFYVE21), Polyclonal Antibody

 Also Known As   

ZF21 Antibody

 Product Synonym Names    ZF21; ZF21; Zinc finger FYVE domain-containing protein 21; ZF21; zinc finger, FYVE domain containing 21
 Product Gene Name   

anti-ZFYVE21 antibody

[Similar Products]
 Antibody/Peptide Pairs    ZF21 peptide (MBS153233) is used for blocking the activity of ZF21 antibody (MBS151011)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    613504
 3D Structure    ModBase 3D Structure for Q9BQ24
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    At least two isoforms of ZF21 are known to exist; this antibody will detect both isoforms.
 Purity/Purification    ZF21 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    ZF21 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human ZF21.
 Buffer    ZF21 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    ZF21 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-ZFYVE21 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ZFYVE21 antibody

   ZF21 Antibody: ZF21 was initially identified as protein that could bind to the cytoplasmic tail of MT1-MMP (Membrane-type 1 matrix metalloproteinase), a potent invasion-promoting protease. ZF21 is a member of a protein family characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain and regulates focal adhesions (FAs) and cell movement. Knockdown of ZF21 expression resulted in a delay of FA disassembly following induction of synchronous disassembly of FAs by nocodazole treatment, suggesting that ZF21 is involved in FA disassembly. ZF21 contains a noncanonical pleckstrin homology domain that is a possible therapeutic target to treat metastatic cancer.
 Applications Tested/Suitable for anti-ZFYVE21 antibody   

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

 Application Notes for anti-ZFYVE21 antibody    ZF21 antibody can be used for detection of ZF21 by Western blot at 1 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-ZFYVE21 antibody    Western blot analysis of ZF21 in 3T3 cell tissue lysate with ZF21 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
anti-ZFYVE21 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-ZFYVE21 antibody    Immunofluorescence of ZF21 in human kidney tissue with ZF21 antibody at 20 μg/mL.
anti-ZFYVE21 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for ZFYVE21. It may not necessarily be applicable to this product.
 NCBI GI #    312147341
 NCBI GeneID    79038
 NCBI Accession #    NP_001185882 [Other Products]
 NCBI GenBank Nucleotide #    NM_001198953.1 [Other Products]
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 UniProt Primary Accession #    Q9BQ24 [Other Products]
 UniProt Secondary Accession #    Q86T05; Q96LT1; A8K3A4 [Other Products]
 UniProt Related Accession #    Q9BQ24 [Other Products]
 Molecular Weight    28,477 Da
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 NCBI Official Full Name    zinc finger FYVE domain-containing protein 21 isoform 1
 NCBI Official Synonym Full Names    zinc finger, FYVE domain containing 21
 NCBI Official Symbol    ZFYVE21 [Similar Products]
 NCBI Official Synonym Symbols   
ZF21
[Similar Products]
 NCBI Protein Information    zinc finger FYVE domain-containing protein 21; FYVE domain containing 21
 UniProt Protein Name    Zinc finger FYVE domain-containing protein 21
 Protein Family    Zinc finger FYVE domain-containing protein
 UniProt Gene Name    ZFYVE21 [Similar Products]
 UniProt Synonym Gene Names    ZF21 [Similar Products]
 UniProt Entry Name    ZFY21_HUMAN
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 UniProt Comments for ZFYVE21    ZFYVE21: Plays a role in cell adhesion, and thereby in cell motility, regulating microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassemblya, as well as integrin beta-1/ITGB1 cell surface expression. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 14q32.33

Cellular Component: focal adhesion; cytoplasmic membrane-bound vesicle; endosome

Molecular Function: metal ion binding
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 Research Articles on ZFYVE21    1. this study demonstrates that ZF21 is a key player regulating multiple aspects of cancer cell migration and invasion.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Organs/Tissues associated with anti-ZFYVE21 antibody
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >1 publications with ZFYVE21 and Skin
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