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anti-ZFYVE27 antibody :: Rabbit ZFYVE27 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9214784
Western Blot (WB)
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ZFYVE27, Polyclonal Antibody

★Popular Item★
 Also Known As   

ZFYVE27 Antibody (N-term)

 Product Synonym Names    Protrudin; Zinc finger FYVE domain-containing protein 27; ZFYVE27
 Product Gene Name   

anti-ZFYVE27 antibody

[Similar Products]
 Antibody/Peptide Pairs    ZFYVE27 peptide (MBS9222301) is used for blocking the activity of ZFYVE27 antibody (MBS9214784)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    28-56
 OMIM    610243
 3D Structure    ModBase 3D Structure for Q5T4F4
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human (Predicted Reactivity: Mouse, Rat)
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 Specificity    This ZFYVE27 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-56 amino acids from the N-terminal region of human ZFYVE27.
 Purity/Purification    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
 Concentration    Vial Concentration: 0.5 (lot specific)
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 Antigen Type    Synthetic Peptide
 Primary Accession    Q5T4F4
 Other Accession    Q6P7B7, Q3TXX3, NP_001002261.1, NP_001002262.1
 Antigen Source    HUMAN
 Function    Functions as an upstream inhibitor of RAB11, regulating directional protein transport to the forming neurites. Involved in nerve growth factor-induced neurite formation. May have a more general role in cell projections formation.
 Cellular Location    Recycling endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, growth cone membrane; Multi- pass membrane protein. Cell membrane; Multi-pass membrane protein Note=Localizes at both dendrites and axons.
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-ZFYVE27 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ZFYVE27 antibody

   This gene encodes a protein with several transmembrane
domains, a Rab11-binding domain and a lipid-binding FYVE finger
domain. The encoded protein appears to promote neurite formation. A
mutation in this gene has been reported to be associated with
hereditary spastic paraplegia, however the pathogenicity of the
mutation, which may simply represent a polymorphism, is unclear.
 Product Categories/Family for anti-ZFYVE27 antibody    Neuroscience
 Applications Tested/Suitable for anti-ZFYVE27 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-ZFYVE27 antibody    WB~~1:1000
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 Western Blot (WB) of anti-ZFYVE27 antibody    ZFYVE27 Antibody (N-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the ZFYVE27 antibody detected the ZFYVE27 protein (arrow).
anti-ZFYVE27 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ZFYVE27. It may not necessarily be applicable to this product.
 NCBI GI #    50557646
 NCBI GeneID    118813
 NCBI Accession #    NP_001002261.1 [Other Products]
 NCBI Related Accession #    NP_001002262.1; NP_001167590.1; NP_001167591.1; NP_001167592.1; NP_001167593.1; NP_653189.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_001002261.3 [Other Products]
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 UniProt Primary Accession #    Q5T4F4 [Other Products]
 UniProt Secondary Accession #    Q5T4F1; Q5T4F2; Q5T4F3; Q8N1K0; Q8N6D6; B7Z3S0; B7Z404; B7Z626; G8JLC3; G8JLF0; J3KP98 [Other Products]
 UniProt Related Accession #    Q5T4F4 [Other Products]
 Molecular Weight    45843
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 NCBI Official Full Name    protrudin isoform a
 NCBI Official Synonym Full Names    zinc finger, FYVE domain containing 27
 NCBI Official Symbol    ZFYVE27 [Similar Products]
 NCBI Official Synonym Symbols   
SPG33; PROTRUDIN
[Similar Products]
 NCBI Protein Information    protrudin
 UniProt Protein Name    Protrudin
 UniProt Synonym Protein Names   
Zinc finger FYVE domain-containing protein 27
 Protein Family    Protrudin
 UniProt Gene Name    ZFYVE27 [Similar Products]
 UniProt Entry Name    ZFY27_HUMAN
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 NCBI Summary for ZFYVE27    This gene encodes a protein with several transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote neurite formation. A mutation in this gene has been reported to be associated with hereditary spastic paraplegia, however the pathogenicity of the mutation, which may simply represent a polymorphism, is unclear. [provided by RefSeq, Mar 2010]
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 UniProt Comments for ZFYVE27    ZFYVE27: Functions as an upstream inhibitor of RAB11, regulating directional protein transport to the forming neurites. Involved in nerve growth factor-induced neurite formation. May have a more general role in cell projections formation. Defects in ZFYVE27 are the cause of spastic paraplegia autosomal dominant type 33 (SPG33). Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. According to PubMed:18606302, the properties of the variant Val-191 and its frequency in some populations raise doubts on the implication of that gene in the disease. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Cytoskeletal

Chromosomal Location of Human Ortholog: 10q24.2

Cellular Component: endoplasmic reticulum membrane; recycling endosome membrane; axon; endoplasmic reticulum; dendrite; integral to membrane

Molecular Function: protein binding; metal ion binding

Biological Process: nerve growth factor receptor signaling pathway; neurite development

Disease: Spastic Paraplegia 33, Autosomal Dominant
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Product References and Citations for anti-ZFYVE27 antibody

   Saita, S., et al. J. Biol. Chem. 284(20):13766-13777(2009)
Martignoni, M., et al. Am. J. Hum. Genet. 83(1):127-128(2008)
Shirane, M., et al. Science 314(5800):818-821(2006)
Mannan, A.U., et al. Am. J. Hum. Genet. 79(2):351-357(2006)
Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)
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 Research Articles on ZFYVE27    1. SPG33 protein protrudin contains hydrophobic, intramembrane hairpin domains, interacts with tubular ER proteins, and functions in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-ZFYVE27 antibodyOrgans/Tissues associated with anti-ZFYVE27 antibody
 Disease Name  Pubmed Publications
 Spastic Paraplegia 33, Autosomal Dominant Antibodies  >1 publications with ZFYVE27 and Spastic Paraplegia 33, Autosomal Dominant
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with ZFYVE27 and Brain
 Skin Antibodies  >1 publications with ZFYVE27 and Skin
 Bladder Antibodies  >1 publications with ZFYVE27 and Bladder
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