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anti-ZIC5 antibody :: Goat ZIC5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421347 anti-ZIC5 antibody
Unit / Price
0.1 mg  /  $225 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ZIC5, Polyclonal Antibody

 Also Known As   

Goat anti-ZIC5 Antibody

 Product Synonym Names    ZIC5; zinc finger protein of the cerebellum 5; zinc family member 5 protein; Zic family member 5 (odd-paired homolog, Drosophila); ZIC5 antibody; zinc finger protein of the cerebellum 5 antibody; zinc family member 5 protein antibody; Zic family member 5 (odd-paired homolog; Drosophila) antibody
 Product Gene Name   

anti-ZIC5 antibody

[Similar Products]
 Antibody/Peptide Pairs    ZIC5 peptide (MBS425208) is used for blocking the activity of ZIC5 antibody (MBS421347)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    EIYGNPEVVR TIH
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-EIYGNPEVVRTIH, from the C Terminus of the protein sequence according to NP_149123.2.
 Epitope    C Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-ZIC5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ZIC5 antibody   

Peptide ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-ZIC5 antibody    Peptide ELISA: Antibody detection limit dilution 1: 128000.
Immunohistochemistry: In paraffin embedded Human Small Intestine shows nuclear staining. Recommended concentration, 3-5ug/ml.
Western Blot: Preliminary experiments gave an approx 45kDa band in human brain lysates at 1ug/ml. This band was successfully blocked by incubation with the immunising peptide. Please note that currently we cannot find an explanation in the literature for the band we observe given the predicted size of approx.73kDda according to NP_149123.
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NCBI/Uniprot data below describe general gene information for ZIC5. It may not necessarily be applicable to this product.
 NCBI GI #    118766337
 NCBI GeneID    85416
 NCBI Accession #    NP_149123.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_033132.3 [Other Products]
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 UniProt Secondary Accession #    Q5VYB0 [Other Products]
 UniProt Related Accession #    Q96T25 [Other Products]
 Molecular Weight    68,448 Da
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 NCBI Official Full Name    zinc finger protein ZIC 5
 NCBI Official Synonym Full Names    Zic family member 5
 NCBI Official Symbol    ZIC5 [Similar Products]
 NCBI Protein Information    zinc finger protein ZIC 5
 UniProt Protein Name    Zinc finger protein ZIC 5
 UniProt Synonym Protein Names   
Zinc finger protein of the cerebellum 5
 Protein Family    Zinc finger protein
 UniProt Gene Name    ZIC5 [Similar Products]
 UniProt Entry Name    ZIC5_HUMAN
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 NCBI Summary for ZIC5    This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development, and have been associated X-linked visceral heterotaxy and holoprosencephaly type 5. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 2, a related family member on chromosome 13. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ZIC5    ZIC5: Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate. Binds to DNA. Belongs to the GLI C2H2-type zinc-finger protein family.

Protein type: Motility/polarity/chemotaxis; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 13q32.3

Cellular Component: nucleus

Molecular Function: DNA binding; metal ion binding

Biological Process: cell differentiation; nervous system development
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 Research Articles on ZIC5    1. ZIC1, ZIC2, and ZIC5 may have roles in meningiomas
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ZIC5 antibodyDiseases associated with anti-ZIC5 antibody
 Products by Pathway  Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram
 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >6 publications with ZIC5 and Brain Diseases
 Abnormalities, Multiple Antibodies  >6 publications with ZIC5 and Abnormalities, Multiple
 Craniofacial Abnormalities Antibodies  >5 publications with ZIC5 and Craniofacial Abnormalities
 Neural Tube Defects Antibodies  >4 publications with ZIC5 and Neural Tube Defects
 Eye Abnormalities Antibodies  >1 publications with ZIC5 and Eye Abnormalities
 Disease Models, Animal Antibodies  >1 publications with ZIC5 and Disease Models, Animal
Organs/Tissues associated with anti-ZIC5 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >13 publications with ZIC5 and Brain
 Embryonic Tissue Antibodies  >5 publications with ZIC5 and Embryonic Tissue
 Eye Antibodies  >3 publications with ZIC5 and Eye
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