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anti-ZIF268 antibody :: Rabbit ZIF268 / EGR1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS240672
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ZIF268 / EGR1, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit Polyclonal to Human ZIF268 / EGR1

 Product Synonym Names    Anti-ZIF268 / EGR1 Antibody (aa94-108) IHC-plus; EGR1; AT225; Early growth response 1; G0S30; KROX24; NGFIA; KROX-24; TIS8; ZIF-268; ZIF268; Zinc finger protein Krox-24; EGR-1; NGFI-A; Transcription factor ETR103; Transcription factor Zif268; Zinc finger protein 225; Human ZIF268; EGR1
 Product Gene Name   

anti-ZIF268 antibody

[Similar Products]
 Product Synonym Gene Name    EGR1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    128990
 3D Structure    ModBase 3D Structure for P18146
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Chimpanzee, Human, Mouse
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 Specificity    Amino acids 94-108 of Human EGR-1.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.
 Concentration    0.93 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human EGR1.
 Immunogen Type    Synthetic peptide
 Immunogen    ZIF268 / EGR1 antibody was raised against synthetic peptide from human EGR1.
 Antigen Modification    aa94-108
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 Preparation and Storage    +4 degree C or -20 degree C, Avoid repeated freezing and thawing.
 Other Notes    Small volumes of anti-ZIF268 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ZIF268 antibody

   EGR-1 (also called Early Growth Response protein 1, Krox-24 protein, ZIF268, Nerve growth factor-induced protein A or NGFI-A, Transcription factor ETR103, and Zinc finger protein 225 or AT225) is a transcriptional regulator that recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3' (EGR-site). EGR1 has been implicated in diverse roles in the regulation of cell growth, apoptosis, and differentiation.
 Applications Tested/Suitable for anti-ZIF268 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-ZIF268 antibody    ELISA (1:4000 - 1:16000), IHC-P (10 ug/ml), WB (1:500 - 1:3000)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibo...
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 Immunohistochemistry (IHC) of anti-ZIF268 antibody    Anti-EGR1 antibody IHC of human lung small cell carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-ZIF268 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-ZIF268 antibody    Anti-EGR-1 Antibody - Western Blot. Western blot of Affinity Purified anti-EGR-1 antibody shows detection of a predominant band at ~58 kD corresponding to EGR-1 present in mouse embryonic fibroblast whole cell lysate (arrowhead). Approximately 35 ug of lysate was separated by 4-20% SDS-PAGE and transferred onto nitrocellulose. After blocking the membrane was probed with the primary antibody diluted to 1:1500. Reaction occurred 2 hours at room temperature followed by washes and reaction with a 1:10000 dilution of IRDye800 conjugated Gt-a-Rabbit IgG [H&L] MX (for 45 min at room temperature. IRDye800 fluorescence image was captured using the Odyssey Infrared Imaging System developed by LI-COR. IRDye is a trademark of LI-COR, Inc. Other detection systems will yield similar results.
anti-ZIF268 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ZIF268. It may not necessarily be applicable to this product.
 NCBI GI #    4503493
 NCBI GeneID    1958
 NCBI Accession #    NP_001955.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001964.2 [Other Products]
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 UniProt Primary Accession #    P18146 [Other Products]
 UniProt Related Accession #    P18146 [Other Products]
 Molecular Weight    57,507 Da
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 NCBI Official Full Name    early growth response protein 1
 NCBI Official Synonym Full Names    early growth response 1
 NCBI Official Symbol    EGR1 [Similar Products]
 NCBI Official Synonym Symbols   
TIS8; AT225; G0S30; NGFI-A; ZNF225; KROX-24; ZIF-268
[Similar Products]
 NCBI Protein Information    early growth response protein 1; EGR-1; zinc finger protein 225; transcription factor ETR103; transcription factor Zif268; zinc finger protein Krox-24; nerve growth factor-induced protein A
 UniProt Protein Name    Early growth response protein 1
 UniProt Synonym Protein Names   
AT225; Nerve growth factor-induced protein A; NGFI-A; Transcription factor ETR103; Transcription factor Zif268; Zinc finger protein 225; Zinc finger protein Krox-24
 UniProt Gene Name    EGR1 [Similar Products]
 UniProt Synonym Gene Names    KROX24; ZNF225; EGR-1; NGFI-A [Similar Products]
 UniProt Entry Name    EGR1_HUMAN
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 NCBI Summary for ZIF268    The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014]
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 UniProt Comments for ZIF268    EGR1: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation. By growth factors. Belongs to the EGR C2H2-type zinc-finger protein family.

Protein type: C2H2-type zinc finger protein; Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: histone acetyltransferase binding; protein binding; DNA binding; sequence-specific DNA binding; metal ion binding; double-stranded DNA binding; transcription factor activity; transcription factor binding

Biological Process: response to nutrient levels; regulation of long-term neuronal synaptic plasticity; circadian rhythm; transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; response to amphetamine; negative regulation of transcription from RNA polymerase II promoter; response to cocaine; BMP signaling pathway; learning and/or memory; response to ethanol; cellular response to insulin stimulus; positive regulation of neuron apoptosis; response to glucose stimulus; oligodendrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; response to electrical stimulus; regulation of protein sumoylation; T cell differentiation; negative regulation of apoptosis
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 Research Articles on ZIF268    1. our results demonstrate that ciglitazone inhibits PDK1 expression through AMPKalpha-mediated induction of Egr-1 and Egr-1 binding to the specific DNA site in the PDK1 gene promoter, which is independent of PPARgamma
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ZIF268 antibodyPathways associated with anti-ZIF268 antibody
 Reference Product  PubMed Publications
 FOS antibody  >607 publications with ZIF268 and FOS
 JUN antibody  >518 publications with ZIF268 and JUN
 NAB2 antibody  >51 publications with ZIF268 and NAB2
 ELK1 antibody  >48 publications with ZIF268 and ELK1
 ATF3 antibody  >42 publications with ZIF268 and ATF3
 NAB1 antibody  >28 publications with ZIF268 and NAB1
 TP53 antibody  >23 publications with ZIF268 and TP53
 NFATC2 antibody  >2 publications with ZIF268 and NFATC2
 SNAI1 antibody  >1 publications with ZIF268 and SNAI1
 NFATC1 antibody  >1 publications with ZIF268 and NFATC1
 Products by Pathway  Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies  Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
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 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
Diseases associated with anti-ZIF268 antibodyOrgans/Tissues associated with anti-ZIF268 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >179 publications with ZIF268 and Nervous System Diseases
 Inflammation Antibodies  >162 publications with ZIF268 and Inflammation
 Cardiovascular Diseases Antibodies  >142 publications with ZIF268 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >140 publications with ZIF268 and Disease Models, Animal
 Necrosis Antibodies  >135 publications with ZIF268 and Necrosis
 Brain Diseases Antibodies  >116 publications with ZIF268 and Brain Diseases
 Ischemia Antibodies  >70 publications with ZIF268 and Ischemia
 Prostatic Neoplasms Antibodies  >62 publications with ZIF268 and Prostatic Neoplasms
 Liver Diseases Antibodies  >54 publications with ZIF268 and Liver Diseases
 Neoplasms, Experimental Antibodies  >51 publications with ZIF268 and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >774 publications with ZIF268 and Brain
 Blood Antibodies  >404 publications with ZIF268 and Blood
 Nerve Antibodies  >275 publications with ZIF268 and Nerve
 Vascular Antibodies  >253 publications with ZIF268 and Vascular
 Muscle Antibodies  >208 publications with ZIF268 and Muscle
 Lung Antibodies  >143 publications with ZIF268 and Lung
 Liver Antibodies  >129 publications with ZIF268 and Liver
 Kidney Antibodies  >128 publications with ZIF268 and Kidney
 Bone Antibodies  >108 publications with ZIF268 and Bone
 Prostate Antibodies  >78 publications with ZIF268 and Prostate
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