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anti-ZMIZ1 antibody :: Rabbit anti-Human ZIMP10 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS151128
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ZIMP10 (ZMIZ1), Polyclonal Antibody

 Also Known As   

ZIMP10 Antibody

 Product Synonym Names    ZIMP10; MIZ; RAI17; ZIMP10; hZIMP10; TRAFIP10; KIAA1224; Zinc finger MIZ domain-containing protein 1; PIAS-like protein Zimp10; zinc finger, MIZ-type containing 1
 Product Gene Name   

anti-ZMIZ1 antibody

[Similar Products]
 Antibody/Peptide Pairs    ZIMP10 peptide (MBS153212) is used for blocking the activity of ZIMP10 antibody (MBS151128)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    607159
 3D Structure    ModBase 3D Structure for Q9ULJ6
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    At least three isoforms are known to exist; this antibody will recognize all three. ZIMP10 antibody is predicted to not cross-react with other PIAS protein family members.
 Purity/Purification    ZIMP10 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    ZIMP10 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human ZIMP10.
 Buffer    ZIMP10 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    ZIMP10 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-ZMIZ1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ZMIZ1 antibody

   ZIMP10 Antibody: ZIMP10, also known as ZMIZ1, is a novel PIAS (protein inhibitor of activated signal transducer and activator of transcription)-like protein initially identified as a transcriptional co-activator of the androgen receptor (AR). ZIMP10 and the related protein ZIMP7 interact with PIAS3 and enhances AR-mediated transcription. Later experiments showed that ZIMP10 is also a co-activator of the p53 tumor suppressor. Mice deficient in ZIMP10 result in embryonic lethality by E10.5; these embryos reveal severe defects in the reorganization of the yolk sac vascular plexus, indicating that ZIMP10 plays an important role in proper vascular development.
 Applications Tested/Suitable for anti-ZMIZ1 antibody   

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

 Application Notes for anti-ZMIZ1 antibody    ZIMP10 antibody can be used for detection of ZIMP10 by Western blot at 0.5 mug/mL. Antibody can also be used for immunocytochemistry starting at 10 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-ZMIZ1 antibody    Western blot analysis of ZIMP10 in K562 cell lysate with ZIMP10 antibody at 0.5 μg/mL in (A) the absence and (B) the presence of blocking peptide
anti-ZMIZ1 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-ZMIZ1 antibody    Immunofluorescence of ZIMP10 in K562 cells with ZIMP10 antibody at 20 μg/mL.
anti-ZMIZ1 antibody Immunofluorescence (IF) image
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 Immunocytochemistry (ICC) of anti-ZMIZ1 antibody    Immunocytochemistry of ZIMP10 in K562 cells with ZIMP10 antibody at 10 μg/mL.
anti-ZMIZ1 antibody Immunocytochemistry (ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for ZMIZ1. It may not necessarily be applicable to this product.
 NCBI GI #    31543543
 NCBI GeneID    57178
 NCBI Accession #    NP_65071 [Other Products]
 NCBI GenBank Nucleotide #    NM_020338.3 [Other Products]
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 UniProt Primary Accession #    Q9ULJ6 [Other Products]
 UniProt Secondary Accession #    Q5JSH9; Q7Z7E6 [Other Products]
 UniProt Related Accession #    Q9ULJ6 [Other Products]
 Molecular Weight    107,270 Da
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 NCBI Official Full Name    zinc finger MIZ domain-containing protein 1
 NCBI Official Synonym Full Names    zinc finger, MIZ-type containing 1
 NCBI Official Symbol    ZMIZ1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    zinc finger MIZ domain-containing protein 1; RP11-519K18.1; FLJ00092 protein; retinoic acid induced 17; zinc finger-containing, Miz1, PIAS-like protein on chromosome 10
 UniProt Protein Name    Zinc finger MIZ domain-containing protein 1
 UniProt Synonym Protein Names   
PIAS-like protein Zimp10; Retinoic acid-induced protein 17
 Protein Family    Zinc finger MIZ domain-containing protein
 UniProt Gene Name    ZMIZ1 [Similar Products]
 UniProt Synonym Gene Names    KIAA1224; RAI17; ZIMP10 [Similar Products]
 UniProt Entry Name    ZMIZ1_HUMAN
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 NCBI Summary for ZMIZ1    This gene encodes a member of the PIAS (protein inhibitor of activated STAT) family of proteins. The encoded protein regulates the activity of various transcription factors, including the androgen receptor, Smad3/4, and p53. The encoded protein may also play a role in sumoylation. A translocation between this locus on chromosome 10 and the protein tyrosine kinase ABL1 locus on chromosome 9 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Mar 2010]
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 UniProt Comments for ZMIZ1    RAI17: Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 10q22.3

Cellular Component: nucleoplasm; intracellular membrane-bound organelle; cytoplasm; nuclear speck

Molecular Function: zinc ion binding

Biological Process: heart morphogenesis; developmental growth; positive regulation of fibroblast proliferation; transcription, DNA-dependent; in utero embryonic development; vitellogenesis; artery morphogenesis; cell aging; positive regulation of transcription from RNA polymerase II promoter; vasculogenesis
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 Research Articles on ZMIZ1    1. ZMIZ1 is overexpressed in a significant percentage of human breast, ovarian, and colon cancers in addition to human squamous cell carcinomas, suggesting that ZMIZ1 may play a broader role in epithelial cancers.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ZMIZ1 antibodyPathways associated with anti-ZMIZ1 antibody
 Reference Product  PubMed Publications
 SMAD4 antibody  >1 publications with ZMIZ1 and SMAD4
 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Coregulation Of Androgen Receptor Activity Pathway antibodies  Coregulation Of Androgen Receptor Activity Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
Diseases associated with anti-ZMIZ1 antibodyOrgans/Tissues associated with anti-ZMIZ1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >3 publications with ZMIZ1 and Inflammation
 Breast Neoplasms Antibodies  >3 publications with ZMIZ1 and Breast Neoplasms
 Celiac Disease Antibodies  >3 publications with ZMIZ1 and Celiac Disease
 Neoplasms, Experimental Antibodies  >2 publications with ZMIZ1 and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >2 publications with ZMIZ1 and Disease Models, Animal
 Colorectal Neoplasms Antibodies  >2 publications with ZMIZ1 and Colorectal Neoplasms
 Adenocarcinoma Antibodies  >1 publications with ZMIZ1 and Adenocarcinoma
 Liver Diseases Antibodies  >1 publications with ZMIZ1 and Liver Diseases
 Kidney Diseases Antibodies  >1 publications with ZMIZ1 and Kidney Diseases
 Abnormalities, Drug-Induced Antibodies  >1 publications with ZMIZ1 and Abnormalities, Drug-Induced
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with ZMIZ1 and Blood
 Ovary Antibodies  >3 publications with ZMIZ1 and Ovary
 Skin Antibodies  >3 publications with ZMIZ1 and Skin
 Connective Tissue Antibodies  >2 publications with ZMIZ1 and Connective Tissue
 Pancreas Antibodies  >2 publications with ZMIZ1 and Pancreas
 Prostate Antibodies  >2 publications with ZMIZ1 and Prostate
 Embryonic Tissue Antibodies  >2 publications with ZMIZ1 and Embryonic Tissue
 Muscle Antibodies  >1 publications with ZMIZ1 and Muscle
 Testis Antibodies  >1 publications with ZMIZ1 and Testis
 Liver Antibodies  >1 publications with ZMIZ1 and Liver
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