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anti-Slc39a14 antibody :: Rabbit ZIP14 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS151580
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ZIP14 (Slc39a14), Polyclonal Antibody

★Popular Item★
 Also Known As   

ZIP14 Antibody

 Product Synonym Names    ZIP14; NET34; ZIP14; cig19; LZT-Hs4; KIAA0062; Zinc transporter ZIP14; LIV-1 subfamily of ZIP zinc transporter 4; solute carrier family 39 (zinc transporter), member 14
 Product Gene Name   

anti-Slc39a14 antibody

[Similar Products]
 Antibody/Peptide Pairs    ZIP14 peptide (MBS153167) is used for blocking the activity of ZIP14 antibody (MBS151580)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    608736
 3D Structure    ModBase 3D Structure for Q15043
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    At least three isoforms of ZIP14 are known to exist; this antibody will detect both isoforms. ZIP14 antibody is predicted to not cross-react with other ZIP family members.
 Purity/Purification    ZIP14 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    ZIP14 antibody was raised against a 16 amino acid synthetic peptide near the center of human ZIP14.
Immunogen is located withing amino acids 230-280 of ZIP14
 Buffer    ZIP14 Antibody is supplied in PBS containing 0.02% sodium azide.
 Predicted Molecular Weight    54 kDa
 Observed Molecular Weight    52 kDa
 Positive Control    MBS151674-Human Spleen Tissue Lysate.
 Homology    Predicted species reactivity bases on immunogen sequence: Bovine: (94%).
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 Preparation and Storage    ZIP14 antibody can be stored at 4C for three months and -20C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-Slc39a14 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Slc39a14 antibody

   ZIP14 Antibody: The zinc transporter ZIP14, also known as SLC39A14, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. The zinc transporter family is divided into four subfamilies (I, II, LIV-1 and gufA). ZIP14 is a glycosylated multipass plasma membrane protein that belongs to the ZIP transporter subfamily LIV-1. ZIP14 has been shown to contribute to the hypozincemia of inflammation and infection and is regulated in the liver by IL-6. In addition to zinc, ZIP14 is also involved in the cellular uptake of non-transferrin-bound iron as well as iron bound to transferrin.
 Applications Tested/Suitable for anti-Slc39a14 antibody   

ELISA. IF, IHC-P, WB

 Application Notes for anti-Slc39a14 antibody    ZIP14 antibody can be used for detection of ZIP14 by Western blot at 1 - 2 ug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 ug/mL. For immunofluorescence start at 20 ug/mL.

Optimal dilutions for each application to be determined by the researcher.
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 Western Blot (WB) of anti-Slc39a14 antibody    Western blot analysis of ZIP14 in human spleen tissue lysate with ZIP14 antibody at (A) 1 and (B) 2 μg/mL.
anti-Slc39a14 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-Slc39a14 antibody    Immunofluorescence of ZIP14 in Mouse Liver tissue with ZIP14 antibody at 20 μg/mL.
anti-Slc39a14 antibody Immunofluorescence (IF) image
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 Immunohistochemistry (IHC) of anti-Slc39a14 antibody    Immunohistochemistry of ZIP14 in mouse liver tissue with ZIP14 antibody at 2.5 μg/mL.
anti-Slc39a14 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for Slc39a14. It may not necessarily be applicable to this product.
 NCBI GI #    205830424
 NCBI GeneID    23516
 NCBI Accession #    NP_001128625 [Other Products]
 NCBI GenBank Nucleotide #    NM_001135153.1 [Other Products]
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 UniProt Primary Accession #    Q15043 [Other Products]
 UniProt Secondary Accession #    Q6ZME8; Q96BB3; A6NH98; B4DIW3; B6EU88; D3DSR4 [Other Products]
 UniProt Related Accession #    Q15043 [Other Products]
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 NCBI Official Full Name    zinc transporter ZIP14 isoform a
 NCBI Official Synonym Full Names    solute carrier family 39 (zinc transporter), member 14
 NCBI Official Symbol    SLC39A14 [Similar Products]
 NCBI Official Synonym Symbols   
NET34; ZIP14; cig19; LZT-Hs4
[Similar Products]
 NCBI Protein Information    zinc transporter ZIP14; ZIP-14; Zrt-, Irt-like protein 14; zrt- and Irt-like protein 14; solute carrier family 39 member 14; LIV-1 subfamily of ZIP zinc transporter 4; solute carrier family 39 (metal ion transporter), member 14
 UniProt Protein Name    Zinc transporter ZIP14
 UniProt Synonym Protein Names   
LIV-1 subfamily of ZIP zinc transporter 4; LZT-Hs4; Solute carrier family 39 member 14; Zrt- and Irt-like protein 14; ZIP-14
 Protein Family    Zinc transporter
 UniProt Gene Name    SLC39A14 [Similar Products]
 UniProt Synonym Gene Names    KIAA0062; ZIP14; LZT-Hs4; ZIP-14 [Similar Products]
 UniProt Entry Name    S39AE_HUMAN
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 NCBI Summary for Slc39a14    Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A14 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]
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 UniProt Comments for Slc39a14    SLC39A14: May mediate cellular uptake of nontransferrin-bound iron. Broad-scope metal ion transporter with a preference for zinc uptake. Belongs to the ZIP transporter (TC 2.A.5) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter, SLC family; Transporter

Chromosomal Location of Human Ortholog: 8p21.3

Cellular Component: Golgi apparatus; lamellipodium; integral to plasma membrane; endoplasmic reticulum; integral to membrane; plasma membrane

Molecular Function: zinc ion transmembrane transporter activity; ferrous iron transmembrane transporter activity

Biological Process: ferrous iron transport; cellular zinc ion homeostasis; transmembrane transport
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 Research Articles on Slc39a14    1. Polymorphisms in SLC39A14 and SLC39A8 seemed to affect blood cadmium concentrations, for SLC39A14 this effect may occur via differential gene expression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Slc39a14 antibodyPathways associated with anti-Slc39a14 antibody
 Reference Product  PubMed Publications
 SLC30A4 antibody  >3 publications with Slc39a14 and SLC30A4
 SLC30A1 antibody  >2 publications with Slc39a14 and SLC30A1
 MET antibody  >2 publications with Slc39a14 and MET
 SLC30A5 antibody  >1 publications with Slc39a14 and SLC30A5
 HFE antibody  >1 publications with Slc39a14 and HFE
 IL6 antibody  >1 publications with Slc39a14 and IL6
 Products by Pathway  Pathway Diagram
 Metal Ion SLC Transporters Pathway antibodies  Metal Ion SLC Transporters Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway antibodies  Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway Diagram
 Zinc Influx Into Cells By The SLC39 Gene Family Pathway antibodies  Zinc Influx Into Cells By The SLC39 Gene Family Pathway Diagram
 Zinc Transporters Pathway antibodies  Zinc Transporters Pathway Diagram
Diseases associated with anti-Slc39a14 antibodyOrgans/Tissues associated with anti-Slc39a14 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >9 publications with Slc39a14 and Inflammation
 Liver Diseases Antibodies  >4 publications with Slc39a14 and Liver Diseases
 Necrosis Antibodies  >3 publications with Slc39a14 and Necrosis
 Fibrosis Antibodies  >2 publications with Slc39a14 and Fibrosis
 Carcinoma, Hepatocellular Antibodies  >2 publications with Slc39a14 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >2 publications with Slc39a14 and Liver Neoplasms
 Drug-Induced Liver Injury Antibodies  >2 publications with Slc39a14 and Drug-Induced Liver Injury
 Drug-Related Side Effects and Adverse Reactions Antibodies  >1 publications with Slc39a14 and Drug-Related Side Effects and Adverse Reactions
 Disease Models, Animal Antibodies  >1 publications with Slc39a14 and Disease Models, Animal
 Poisoning Antibodies  >1 publications with Slc39a14 and Poisoning
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >19 publications with Slc39a14 and Liver
 Lung Antibodies  >9 publications with Slc39a14 and Lung
 Kidney Antibodies  >8 publications with Slc39a14 and Kidney
 Intestine Antibodies  >6 publications with Slc39a14 and Intestine
 Blood Antibodies  >4 publications with Slc39a14 and Blood
 Heart Antibodies  >4 publications with Slc39a14 and Heart
 Vascular Antibodies  >3 publications with Slc39a14 and Vascular
 Pancreas Antibodies  >3 publications with Slc39a14 and Pancreas
 Muscle Antibodies  >2 publications with Slc39a14 and Muscle
 Adipose Tissue Antibodies  >2 publications with Slc39a14 and Adipose Tissue
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