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anti-Slc39a8 antibody :: Rabbit anti-Human ZIP8 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS151012
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ZIP8 (Slc39a8), Polyclonal Antibody

 Also Known As   

ZIP8 Antibody

 Product Synonym Names    ZIP8; ZIP8; PP3105; BIGM103; LZT-Hs6; ZIP8; Zinc transporter ZIP8; BCG-induced integral membrane protein in monocyte clone 103 protein; solute carrier family 39 (zinc transporter), member 8
 Product Gene Name   

anti-Slc39a8 antibody

[Similar Products]
 Antibody/Peptide Pairs    ZIP8 peptide (MBS151851) is used for blocking the activity of ZIP8 antibody (MBS151012)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    608732
 3D Structure    ModBase 3D Structure for Q9C0K1
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    ZIP8 antibody is predicted to not cross-react with other ZIP family members.
 Purity/Purification    ZIP8 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    ZIP8 antibody was raised against a 18 amino acid synthetic peptide near the carboxy terminus of human ZIP8.
 Buffer    ZIP8 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    ZIP8 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-Slc39a8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Slc39a8 antibody

   ZIP8 Antibody: The zinc transporter ZIP8, also known as SLC39A9, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. The zinc transporter family is divided into four subfamilies (I, II, LIV-1 and gufA). ZIP8 is glycosylated and located at the plasma membrane and mitochondria. It has been identified as the transporter responsible for transport of the toxic Cadmium cation. ZIP8 has also been suggested to play a role in the regulation of interferon-gamma expression in activated human T cells.
 Applications Tested/Suitable for anti-Slc39a8 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-Slc39a8 antibody    ZIP8 antibody can be used for detection of ZIP8 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-Slc39a8 antibody    Western blot analysis of ZIP8 in human spleen tissue lysate with ZIP8 antibody at (A) 1 and (B) 2 μg/mL.
anti-Slc39a8 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-Slc39a8 antibody    Immunofluorescence of ZIP8 in human spleen tissue with ZIP8 antibody at 20 μg/mL.
anti-Slc39a8 antibody Immunofluorescence (IF) image
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 Immunohistochemistry (IHC) of anti-Slc39a8 antibody    Immunohistochemistry of ZIP8 in human spleen tissue with ZIP8 antibody at 5 μg/mL.
anti-Slc39a8 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for Slc39a8. It may not necessarily be applicable to this product.
 NCBI GI #    205830403
 NCBI GeneID    64116
 NCBI Accession #    NP_071437 [Other Products]
 NCBI GenBank Nucleotide #    NM_001135146.1 [Other Products]
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 UniProt Primary Accession #    Q9C0K1 [Other Products]
 UniProt Secondary Accession #    Q96SM9; Q9BVC0; Q9NSA4; B4E2H3 [Other Products]
 UniProt Related Accession #    Q9C0K1 [Other Products]
 Molecular Weight    48,089 Da
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 NCBI Official Full Name    zinc transporter ZIP8 isoform a
 NCBI Official Synonym Full Names    solute carrier family 39 (zinc transporter), member 8
 NCBI Official Symbol    SLC39A8 [Similar Products]
 NCBI Official Synonym Symbols   
ZIP8; PP3105; BIGM103; LZT-Hs6
[Similar Products]
 NCBI Protein Information    zinc transporter ZIP8; ZIP-8; Zrt- and Irt-like protein 8; solute carrier family 39 member 8; LIV-1 subfamily of ZIP zinc transporter 6; BCG induced integral membrane protein BIGM103; solute carrier family 39 (metal ion transporter), member 8; BCG-induced integral membrane protein in monocyte clone 103 protein
 UniProt Protein Name    Zinc transporter ZIP8
 UniProt Synonym Protein Names   
BCG-induced integral membrane protein in monocyte clone 103 protein; LIV-1 subfamily of ZIP zinc transporter 6; LZT-Hs6; Solute carrier family 39 member 8; Zrt- and Irt-like protein 8; ZIP-8
 Protein Family    Zinc transporter
 UniProt Gene Name    SLC39A8 [Similar Products]
 UniProt Synonym Gene Names    BIGM103; ZIP8; LZT-Hs6; ZIP-8 [Similar Products]
 UniProt Entry Name    S39A8_HUMAN
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 NCBI Summary for Slc39a8    This gene encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of zinc transporters. The encoded protein is glycosylated and found in the plasma membrane and mitochondria, and functions in the cellular import of zinc at the onset of inflammation. It is also thought to be the primary transporter of the toxic cation cadmium, which is found in cigarette smoke. Multiple transcript variants encoding different isoforms have been found for this gene. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Oct 2008]
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 UniProt Comments for Slc39a8    SLC39A8: Acts as a zinc-influx transporter. Belongs to the ZIP transporter (TC 2.A.5) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Transporter, SLC family; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 4q24

Cellular Component: plasma membrane; integral to membrane

Molecular Function: metal ion transmembrane transporter activity

Biological Process: zinc ion transport; transmembrane transport
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 Research Articles on Slc39a8    1. Polymorphisms in SLC39A14 and SLC39A8 seemed to affect blood cadmium concentrations, for SLC39A14 this effect may occur via differential gene expression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Slc39a8 antibodyPathways associated with anti-Slc39a8 antibody
 Reference Product  PubMed Publications
 SLC6A15 antibody  >1 publications with Slc39a8 and SLC6A15
 SLC39A1 antibody  >1 publications with Slc39a8 and SLC39A1
 SLC30A4 antibody  >1 publications with Slc39a8 and SLC30A4
 SLC30A1 antibody  >1 publications with Slc39a8 and SLC30A1
 SLC30A5 antibody  >1 publications with Slc39a8 and SLC30A5
 Products by Pathway  Pathway Diagram
 Metal Ion SLC Transporters Pathway antibodies  Metal Ion SLC Transporters Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway antibodies  Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway Diagram
 Zinc Influx Into Cells By The SLC39 Gene Family Pathway antibodies  Zinc Influx Into Cells By The SLC39 Gene Family Pathway Diagram
 Zinc Transporters Pathway antibodies  Zinc Transporters Pathway Diagram
Diseases associated with anti-Slc39a8 antibodyOrgans/Tissues associated with anti-Slc39a8 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >7 publications with Slc39a8 and Inflammation
 Necrosis Antibodies  >6 publications with Slc39a8 and Necrosis
 Kidney Diseases Antibodies  >4 publications with Slc39a8 and Kidney Diseases
 Liver Diseases Antibodies  >3 publications with Slc39a8 and Liver Diseases
 Anemia Antibodies  >2 publications with Slc39a8 and Anemia
 Acute Kidney Injury Antibodies  >2 publications with Slc39a8 and Acute Kidney Injury
 Fibrosis Antibodies  >2 publications with Slc39a8 and Fibrosis
 Heart Diseases Antibodies  >2 publications with Slc39a8 and Heart Diseases
 Nervous System Diseases Antibodies  >2 publications with Slc39a8 and Nervous System Diseases
 Drug-Induced Liver Injury Antibodies  >2 publications with Slc39a8 and Drug-Induced Liver Injury
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >14 publications with Slc39a8 and Kidney
 Lung Antibodies  >13 publications with Slc39a8 and Lung
 Blood Antibodies  >12 publications with Slc39a8 and Blood
 Testis Antibodies  >9 publications with Slc39a8 and Testis
 Liver Antibodies  >8 publications with Slc39a8 and Liver
 Heart Antibodies  >5 publications with Slc39a8 and Heart
 Placenta Antibodies  >4 publications with Slc39a8 and Placenta
 Intestine Antibodies  >3 publications with Slc39a8 and Intestine
 Brain Antibodies  >3 publications with Slc39a8 and Brain
 Embryonic Tissue Antibodies  >2 publications with Slc39a8 and Embryonic Tissue
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