NP_067009.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 65 kD Predicted: 60 kDa
NCBI Official Full Name
zona pellucida sperm-binding protein 4 preproprotein
NCBI Official Synonym Full Names
zona pellucida glycoprotein 4
NCBI Protein Information
zona pellucida sperm-binding protein 4
UniProt Protein Name
Zona pellucida sperm-binding protein 4
UniProt Synonym Protein Names
Zona pellucida glycoprotein 4; Zp-4
UniProt Synonym Gene Names
NCBI Summary for ZP4
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. Previously, this gene has been referred to as ZP1 or ZPB and thought to have similar functions as mouse Zp1. However, a human gene with higher similarity and chromosomal synteny to mouse Zp1 has been assigned the symbol ZP1 and this gene has been assigned the symbol ZP4. [provided by RefSeq, Jul 2008]
UniProt Comments for ZP4
The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.
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Products associated with anti-ZP4 antibody
Diseases associated with anti-ZP4 antibody
Organs/Tissues associated with anti-ZP4 antibody
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