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anti-AFP antibody :: Rabbit anti-Human a-Fetoprotein Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS6012008 anti-AFP antibody
Unit / Price
0.05 mL  /  $630 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

a-Fetoprotein (AFP), Polyclonal Antibody

 Also Known As   

a-Fetoprotein, ID (Alpha Fetoprotein, Alpha-fetoprotein Precursor, AFP, Alpha-1-fetoprotein, Alpha-fetoglobulin, FETA, HPAFP)

 Product Synonym Names    Anti -a-Fetoprotein, ID (Alpha Fetoprotein, Alpha-fetoprotein Precursor, AFP, Alpha-1-fetoprotein, Alpha-fetoglobulin, FETA, HPAFP)
 Product Gene Name   

anti-AFP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 4; NC_000004.11 (74301933..74321492). Location: 4q13.3
 OMIM    104150
 3D Structure    ModBase 3D Structure for P02771
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Recognizes human AFP.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.4.
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 Immunogen    Synthetic peptide corresponding to human AFP.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-AFP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-AFP antibody

   AFP is normally synthesized in the liver, intestinal tract, and yolk sac of the fetus. Antibody to AFP has been shown to be useful in detecting hepatocellular carcinomas (HCC) and germ cell neoplasms, especially yolk sac tumors.
 Product Categories/Family for anti-AFP antibody    Antibodies; Abs to Serum Proteins
 Applications Tested/Suitable for anti-AFP antibody   

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-AFP antibody    Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 2.5ug/ml
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NCBI/Uniprot data below describe general gene information for AFP. It may not necessarily be applicable to this product.
 NCBI GI #    4501989
 NCBI GeneID    174
 NCBI Accession #    NP_001125.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001134.2 [Other Products]
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 UniProt Primary Accession #    P02771 [Other Products]
 UniProt Secondary Accession #    B2RBU3 [Other Products]
 UniProt Related Accession #    P02771 [Other Products]
 Molecular Weight    68,678 Da [Similar Products]
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 NCBI Official Full Name    alpha-fetoprotein
 NCBI Official Synonym Full Names    alpha-fetoprotein
 NCBI Official Symbol    AFP [Similar Products]
 NCBI Official Synonym Symbols   
FETA; HPAFP
[Similar Products]
 NCBI Protein Information    alpha-fetoprotein; alpha-fetoglobulin; alpha-1-fetoprotein
 UniProt Protein Name    Alpha-fetoprotein
 UniProt Synonym Protein Names   
Alpha-1-fetoprotein; Alpha-fetoglobulin
 Protein Family    Alpha-fetoprotein
 UniProt Gene Name    AFP [Similar Products]
 UniProt Synonym Gene Names    HPAFP [Similar Products]
 UniProt Entry Name    FETA_HUMAN
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 NCBI Summary for AFP    This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008]
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 UniProt Comments for AFP    AFP: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties. Dimeric and trimeric forms have been found in addition to the monomeric form. Plasma. Synthesized by the fetal liver and yolk sac. Belongs to the ALB/AFP/VDB family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: extracellular space; cytoplasm

Molecular Function: metal ion binding

Biological Process: transport; progesterone metabolic process; ovulation from ovarian follicle

Disease: Alpha-fetoprotein Deficiency; Alpha-fetoprotein, Hereditary Persistence Of
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 Research Articles on AFP    1. GPC3 is comparable to AFP as a serum marker for the diagnosis of HCC, combination of AFP and GPC3 can elevate the sensitivity of diagnosis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-AFP antibodyPathways associated with anti-AFP antibody
 Reference Product  PubMed Publications
 JUN antibody  >876 publications with AFP and JUN
 GPC3 antibody  >51 publications with AFP and GPC3
 IGFBP1 antibody  >16 publications with AFP and IGFBP1
 FOXA1 antibody  >10 publications with AFP and FOXA1
 TP53 antibody  >4 publications with AFP and TP53
 FOXA3 antibody  >3 publications with AFP and FOXA3
 Products by Pathway  Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
Diseases associated with anti-AFP antibodyOrgans/Tissues associated with anti-AFP antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >5066 publications with AFP and Neoplasms
 Carcinoma Antibodies  >3922 publications with AFP and Carcinoma
 Liver Diseases Antibodies  >3588 publications with AFP and Liver Diseases
 Liver Neoplasms Antibodies  >3505 publications with AFP and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >3212 publications with AFP and Carcinoma, Hepatocellular
 Adenocarcinoma Antibodies  >3105 publications with AFP and Adenocarcinoma
 Nervous System Diseases Antibodies  >1188 publications with AFP and Nervous System Diseases
 Liver Cirrhosis Antibodies  >993 publications with AFP and Liver Cirrhosis
 Neoplasm Metastasis Antibodies  >492 publications with AFP and Neoplasm Metastasis
 Neoplasms, Experimental Antibodies  >420 publications with AFP and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >4375 publications with AFP and Liver
 Blood Antibodies  >3398 publications with AFP and Blood
 Vascular Antibodies  >498 publications with AFP and Vascular
 Lung Antibodies  >373 publications with AFP and Lung
 Brain Antibodies  >309 publications with AFP and Brain
 Embryonic Tissue Antibodies  >281 publications with AFP and Embryonic Tissue
 Muscle Antibodies  >193 publications with AFP and Muscle
 Kidney Antibodies  >173 publications with AFP and Kidney
 Placenta Antibodies  >162 publications with AFP and Placenta
 Uterus Antibodies  >97 publications with AFP and Uterus
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