NP_037050.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
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NCBI Official Full Name
voltage-dependent P/Q-type calcium channel subunit alpha-1A
NCBI Official Synonym Full Names
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
NCBI Protein Information
voltage-dependent P/Q-type calcium channel subunit alpha-1A; BI; RBA-I; brain class A; brain calcium channel 1; brain calcium channel I; calcium channel alpha 1A; voltage-gated calcium channel subunit alpha Cav2.1; calcium channel, voltage-dependent, alpha 1A subunit; calcium channel, L type, alpha-1 polypeptide, isoform 4
UniProt Protein Name
Voltage-dependent P/Q-type calcium channel subunit alpha-1A
UniProt Synonym Protein Names
Brain calcium channel I; BI; Calcium channel, L type, alpha-1 polypeptide, isoform 4; Rat brain class A; RBA-I; Voltage-gated calcium channel subunit alpha Cav2.1
UniProt Synonym Gene Names
UniProt Entry Name
CAC1A_RAT
NCBI Summary for Cacna1a
voltage-gated calcium channel that may be involved in secretion coupling in pancreatic beta cells [RGD, Feb 2006]
UniProt Comments for Cacna1a
Function: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by the funnel toxin (Ftx) and by the omega-agatoxin-IVA (omega-Aga-IVA). They are however insensitive to dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).
Subunit structure: Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1, alpha-2, beta and delta subunits in a 1:1:1:1 ratio. The channel activity is directed by the pore-forming and voltage-sensitive alpha-1 subunit. In many cases, this subunit is sufficient to generate voltage-sensitive calcium channel activity. The auxiliary subunits beta and alpha-2/delta linked by a disulfide bridge regulate the channel activity. Interact (via C-terminal CDB motif) with CABP1 in the pre- and postsynaptic membranes.
Subcellular location: Membrane; Multi-pass membrane protein.
Tissue specificity: Brain specific. Purkinje cells contain predominantly P-type VSCC, the Q-type being a prominent calcium current in cerebellar granule cells. Also found in heart, in kidney distal convoluted tubule (DCT), and in pituitary.
Domain: Each of the four internal repeats contains five hydrophobic transmembrane segments (S1, S2, S3, S5, S6) and one positively charged transmembrane segment (S4). S4 segments probably represent the voltage-sensor and are characterized by a series of positively charged amino acids at every third position.
Sequence similarities: Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1A subfamily. [View classification]
Research Articles on Cacna1a
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Pathways associated with anti-Cacna1a antibody
Diseases associated with anti-Cacna1a antibody
Organs/Tissues associated with anti-Cacna1a antibody
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