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anti-ACVR1C antibody :: Rabbit activin A receptor, type IC Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS713718 anti-ACVR1C antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

activin A receptor, type IC (ACVR1C), Polyclonal Antibody

 Also Known As   

Rabbit anti-human activin A receptor, type IC polyclonal Antibody

 Product Synonym Names    activin A receptor; type IC; ACVR1C; ACVRLK7; ALK7
 Product Gene Name   

anti-ACVR1C antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    608981
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human ACVR1C
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-54157 / sc-135001
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-ACVR1C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ACVR1C antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for ACVR1C. It may not necessarily be applicable to this product.
 NCBI GI #    161333835
 NCBI GeneID    130399
 NCBI Accession #    NP_001104501.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001111031.1 [Other Products]
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 UniProt Secondary Accession #    Q4ZFZ8; Q86UL1; Q86UL2; Q8TBG2 [Other Products]
 UniProt Related Accession #    Q8NER5 [Other Products]
 Molecular Weight    49,684 Da [Similar Products]
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 NCBI Official Full Name    activin receptor type-1C isoform 2
 NCBI Official Synonym Full Names    activin A receptor, type IC
 NCBI Official Symbol    ACVR1C [Similar Products]
 NCBI Official Synonym Symbols   
ALK7; ACVRLK7
[Similar Products]
 NCBI Protein Information    activin receptor type-1C; ALK-7; ACVR1C; ACTR-IC; activin receptor type IC; activin receptor-like kinase 7
 UniProt Protein Name    Activin receptor type-1C
 UniProt Synonym Protein Names   
Activin receptor type IC; ACTR-IC; Activin receptor-like kinase 7; ALK-7
 Protein Family    Activin receptor
 UniProt Gene Name    ACVR1C [Similar Products]
 UniProt Synonym Gene Names    ACTR-IC; ALK-7 [Similar Products]
 UniProt Entry Name    ACV1C_HUMAN
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 NCBI Summary for ACVR1C    ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008]
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 UniProt Comments for ACVR1C    ALK7: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Kinase, protein; Protein kinase, TKL; EC 2.7.11.30; Protein kinase, Ser/Thr (receptor); TKL group; STKR family; Type1 subfamily

Chromosomal Location of Human Ortholog: 2q24.1

Cellular Component: plasma membrane; activin receptor complex

Molecular Function: transforming growth factor beta receptor activity; activin receptor activity, type I; growth factor binding; metal ion binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: response to dietary excess; sequestering of lipid; apoptotic nuclear changes; response to glucose stimulus; positive regulation of caspase activity; cell differentiation; protein amino acid phosphorylation; response to insulin stimulus; negative regulation of insulin secretion
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 Research Articles on ACVR1C    1. ACVR 1C is a tumor suppressor, and lowered ACVR 1C expression is an important marker for the metastasis, invasion, and prognosis of gallbladder cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ACVR1C antibodyPathways associated with anti-ACVR1C antibody
 Reference Product  PubMed Publications
 NODAL antibody  >26 publications with ACVR1C and NODAL
 SMAD2 antibody  >21 publications with ACVR1C and SMAD2
 GDF3 antibody  >5 publications with ACVR1C and GDF3
 ACVR1 antibody  >4 publications with ACVR1C and ACVR1
 INHBB antibody  >3 publications with ACVR1C and INHBB
 TDGF1 antibody  >3 publications with ACVR1C and TDGF1
 CCNG2 antibody  >2 publications with ACVR1C and CCNG2
 Products by Pathway  Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Regulation Of Signaling By NODAL Pathway antibodies  Regulation Of Signaling By NODAL Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Activin Pathway antibodies  Signaling By Activin Pathway Diagram
 Signaling By NODAL Pathway antibodies  Signaling By NODAL Pathway Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
Diseases associated with anti-ACVR1C antibodyOrgans/Tissues associated with anti-ACVR1C antibody
 Disease Name  Pubmed Publications
 Ovarian Neoplasms Antibodies  >5 publications with ACVR1C and Ovarian Neoplasms
 Fibrosis Antibodies  >3 publications with ACVR1C and Fibrosis
 Disease Models, Animal Antibodies  >3 publications with ACVR1C and Disease Models, Animal
 Breast Neoplasms Antibodies  >2 publications with ACVR1C and Breast Neoplasms
 Liver Diseases Antibodies  >2 publications with ACVR1C and Liver Diseases
 Skin Diseases Antibodies  >2 publications with ACVR1C and Skin Diseases
 Kidney Diseases Antibodies  >2 publications with ACVR1C and Kidney Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with ACVR1C and Cell Transformation, Neoplastic
 Prostatic Neoplasms Antibodies  >1 publications with ACVR1C and Prostatic Neoplasms
 Liver Neoplasms Antibodies  >1 publications with ACVR1C and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with ACVR1C and Brain
 Adipose Tissue Antibodies  >4 publications with ACVR1C and Adipose Tissue
 Lung Antibodies  >2 publications with ACVR1C and Lung
 Spleen Antibodies  >1 publications with ACVR1C and Spleen
 Intestine Antibodies  >1 publications with ACVR1C and Intestine
 Mammary Gland Antibodies  >1 publications with ACVR1C and Mammary Gland
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