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anti-ADD2 antibody :: Rabbit adducin 2 (beta) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS713131 anti-ADD2 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

adducin 2 (beta) (ADD2), Polyclonal Antibody

 Also Known As   

Rabbit anti-human adducin 2 (beta) polyclonal Antibody

 Product Synonym Names    adducin 2 (beta); ADD2; ADDB
 Product Gene Name   

anti-ADD2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    102681
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human ADD2
 Storage Buffer    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-11878 / sc-11880 / sc-25732
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-ADD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ADD2 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for ADD2. It may not necessarily be applicable to this product.
 NCBI GI #    119620214
 NCBI GeneID    119
 NCBI Accession #    EAW99808.1 [Other Products]
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 UniProt Secondary Accession #    Q13482; Q16412; Q59G82; Q5U5P4; Q6P0P2; Q6PGQ4; Q7Z688; A8K4P2; B4DM17; D6W5G7; D6W5G8 [Other Products]
 UniProt Related Accession #    P35612 [Other Products]
 Molecular Weight    64,217 Da [Similar Products]
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 NCBI Official Full Name    adducin 2 (beta), isoform CRA_i
 NCBI Official Synonym Full Names    adducin 2 (beta)
 NCBI Official Symbol    ADD2 [Similar Products]
 NCBI Official Synonym Symbols   
ADDB
[Similar Products]
 NCBI Protein Information    beta-adducin; erythrocyte adducin subunit beta
 UniProt Protein Name    Beta-adducin
 UniProt Synonym Protein Names   
Erythrocyte adducin subunit beta
 Protein Family    Aminodeoxyfutalosine deaminase
 UniProt Gene Name    ADD2 [Similar Products]
 UniProt Synonym Gene Names    ADDB [Similar Products]
 UniProt Entry Name    ADDB_HUMAN
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 NCBI Summary for ADD2    Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]
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 UniProt Comments for ADD2    ADD2: a cytoskeletal protein that promotes the assembly of the spectrin-actin network. Adducin is a heterodimeric protein that consists of related subunits. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Beta-adducin is restricted to brain and hematopoietic tissues. Three alternatively-spliced isoforms have been described.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2p13.3

Cellular Component: F-actin capping protein complex; cytoplasmic membrane-bound vesicle; plasma membrane

Molecular Function: actin filament binding; calmodulin binding; protein homodimerization activity; spectrin binding; protein heterodimerization activity; structural molecule activity; actin binding

Biological Process: actin filament bundle formation; positive regulation of protein binding; protein complex assembly; hemopoiesis; actin cytoskeleton organization and biogenesis; barbed-end actin filament capping
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 Research Articles on ADD2    1. chorein interacts with beta-adducin and beta-actin.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-ADD2 antibodyOrgans/Tissues associated with anti-ADD2 antibody
 Disease Name  Pubmed Publications
 Hypertension Antibodies  >17 publications with ADD2 and Hypertension
 Cardiovascular Diseases Antibodies  >13 publications with ADD2 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >3 publications with ADD2 and Nervous System Diseases
 Mental Disorders Antibodies  >1 publications with ADD2 and Mental Disorders
 Memory Disorders Antibodies  >1 publications with ADD2 and Memory Disorders
 Brain Diseases Antibodies  >1 publications with ADD2 and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >19 publications with ADD2 and Blood
 Brain Antibodies  >12 publications with ADD2 and Brain
 Kidney Antibodies  >4 publications with ADD2 and Kidney
 Bone Antibodies  >3 publications with ADD2 and Bone
 Bone Marrow Antibodies  >3 publications with ADD2 and Bone Marrow
 Nerve Antibodies  >2 publications with ADD2 and Nerve
 Heart Antibodies  >1 publications with ADD2 and Heart
 Liver Antibodies  >1 publications with ADD2 and Liver
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