EAW99808.1
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
adducin 2 (beta), isoform CRA_i
NCBI Official Synonym Full Names
adducin 2 (beta)
NCBI Official Synonym Symbols
NCBI Protein Information
beta-adducin; erythrocyte adducin subunit beta
UniProt Protein Name
Beta-adducin
UniProt Synonym Protein Names
Erythrocyte adducin subunit beta
UniProt Synonym Gene Names
UniProt Entry Name
ADDB_HUMAN
NCBI Summary for ADD2
Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]
UniProt Comments for ADD2
ADD2: a cytoskeletal protein that promotes the assembly of the spectrin-actin network. Adducin is a heterodimeric protein that consists of related subunits. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Beta-adducin is restricted to brain and hematopoietic tissues. Three alternatively-spliced isoforms have been described.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2p13.3
Cellular Component: F-actin capping protein complex; cytoplasmic membrane-bound vesicle; plasma membrane
Molecular Function: actin filament binding; calmodulin binding; protein homodimerization activity; spectrin binding; protein heterodimerization activity; structural molecule activity; actin binding
Biological Process: actin filament bundle formation; positive regulation of protein binding; protein complex assembly; hemopoiesis; actin cytoskeleton organization and biogenesis; barbed-end actin filament capping
Research Articles on ADD2
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Diseases associated with anti-ADD2 antibody
Organs/Tissues associated with anti-ADD2 antibody
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