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anti-ADRB2 antibody :: Rabbit adrenergic, beta-2-, receptor, surface Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS714271 anti-ADRB2 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

adrenergic, beta-2-, receptor, surface (ADRB2), Polyclonal Antibody

 Also Known As   

Rabbit anti-human adrenergic, beta-2-, receptor, surface polyclonal Antibody

 Product Synonym Names    adrenergic; beta-2-; receptor; surface; ADRB2; ADRB2R; ADRBR; B2AR; BAR; BETA2AR
 Product Gene Name   

anti-ADRB2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    109690
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human ADRB2
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-9042 / sc-569 / sc-570
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-ADRB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ADRB2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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NCBI/Uniprot data below describe general gene information for ADRB2. It may not necessarily be applicable to this product.
 NCBI GI #    127798637
 NCBI GeneID    154
 NCBI Accession #    AAH63486.2 [Other Products]
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 UniProt Secondary Accession #    O14823; O14824; O14825; O14826; Q4JG18; Q53GA6; Q6GMT4; Q6P4D8; Q8NEQ9; B0LPE4; B2R7X2 [Other Products]
 UniProt Related Accession #    P07550 [Other Products]
 Molecular Weight    46,459 Da [Similar Products]
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 NCBI Official Full Name    Adrenergic, beta-2-, receptor, surface
 NCBI Official Synonym Full Names    adrenoceptor beta 2, surface
 NCBI Official Symbol    ADRB2 [Similar Products]
 NCBI Official Synonym Symbols   
BAR; B2AR; ADRBR; ADRB2R; BETA2AR
[Similar Products]
 NCBI Protein Information    beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor; catecholamine receptor; adrenoceptor beta 2 surface; adrenergic, beta-2-, receptor, surface
 UniProt Protein Name    Beta-2 adrenergic receptor
 UniProt Synonym Protein Names   
Beta-2 adrenoreceptor; Beta-2 adrenoceptor
 Protein Family    Beta-2 adrenergic receptor
 UniProt Gene Name    ADRB2 [Similar Products]
 UniProt Synonym Gene Names    ADRB2R; B2AR; Beta-2 adrenoceptor [Similar Products]
 UniProt Entry Name    ADRB2_HUMAN
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 NCBI Summary for ADRB2    This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ADRB2    ADRB2: Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 5q31-q32

Cellular Component: integral to plasma membrane; lysosome; apical plasma membrane; plasma membrane; nucleus; receptor complex; endosome

Molecular Function: protein binding; potassium channel regulator activity; protein homodimerization activity; beta2-adrenergic receptor activity; norepinephrine binding; adenylate cyclase binding

Biological Process: arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway; receptor-mediated endocytosis; diet induced thermogenesis; transmembrane receptor protein tyrosine kinase activation (dimerization); negative regulation of multicellular organism growth; regulation of vasodilation; adenylate cyclase activation; regulation of sodium ion transport; positive regulation of bone mineralization; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; cell surface receptor linked signal transduction; positive regulation of MAPKKK cascade; positive regulation of protein ubiquitination; negative regulation of smooth muscle contraction; heat generation; brown fat cell differentiation; endosome to lysosome transport; positive regulation of transcription from RNA polymerase II promoter; response to cold; norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure; bone resorption

Disease: Obesity; Asthma, Susceptibility To
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 Research Articles on ADRB2    1. The study provides the first preliminary evidence that Gln27Glu polymorphism of beta-2 adrenergic receptor may contribute modest effect in increase in risk of intracerebral hemorrhagic stroke in North Indian Population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ADRB2 antibodyDiseases associated with anti-ADRB2 antibody
 Products by Pathway  Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenoceptors Pathway antibodies  Adrenoceptors Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Arf6 Signaling Events Pathway antibodies  Arf6 Signaling Events Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >1046 publications with ADRB2 and Cardiovascular Diseases
 Asthma Antibodies  >781 publications with ADRB2 and Asthma
 Lung Diseases Antibodies  >754 publications with ADRB2 and Lung Diseases
 Heart Diseases Antibodies  >718 publications with ADRB2 and Heart Diseases
 Hypertension Antibodies  >464 publications with ADRB2 and Hypertension
 Heart Failure Antibodies  >454 publications with ADRB2 and Heart Failure
 Nervous System Diseases Antibodies  >331 publications with ADRB2 and Nervous System Diseases
 Obesity Antibodies  >232 publications with ADRB2 and Obesity
 Inflammation Antibodies  >222 publications with ADRB2 and Inflammation
 Myocardial Ischemia Antibodies  >184 publications with ADRB2 and Myocardial Ischemia
Organs/Tissues associated with anti-ADRB2 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2007 publications with ADRB2 and Blood
 Heart Antibodies  >2004 publications with ADRB2 and Heart
 Lung Antibodies  >808 publications with ADRB2 and Lung
 Brain Antibodies  >714 publications with ADRB2 and Brain
 Kidney Antibodies  >279 publications with ADRB2 and Kidney
 Trachea Antibodies  >261 publications with ADRB2 and Trachea
 Connective Tissue Antibodies  >232 publications with ADRB2 and Connective Tissue
 Liver Antibodies  >191 publications with ADRB2 and Liver
 Eye Antibodies  >129 publications with ADRB2 and Eye
 Uterus Antibodies  >129 publications with ADRB2 and Uterus
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